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carboetomidate

a pyrrole analog of etomidate designed not to suppress adrenocortical function; structure in first source

Also Known As:

(R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - carboetomidate: 2

Experts

1.	Cotten, Joseph F: 2 articles (01/2012 - 03/2010)
2.	Raines, Douglas E: 2 articles (01/2012 - 03/2010)
3.	Chao, Wei: 1 article (01/2012)
4.	Feng, Yan: 1 article (01/2012)
5.	Le Ge, Ri: 1 article (01/2012)
6.	Pejo, Ervin: 1 article (01/2012)
7.	Cuny, Gregory D: 1 article (03/2010)
8.	Forman, Stuart A: 1 article (03/2010)
9.	Husain, S Shaukat: 1 article (03/2010)
10.	Kelly, Elizabeth W: 1 article (03/2010)

Related Diseases

1.	Endotoxemia 01/01/2012 - "The objective of this study was to test the hypothesis that in contrast to etomidate, carboetomidate neither suppresses the adrenocortical response to endotoxemia nor enhances the accompanying production of proinflammatory cytokines. " 01/01/2012 - "Compared with etomidate, carboetomidate produces less suppression of adrenocortical function and smaller increases in proinflammatory cytokine production in an endotoxemia model of sepsis. " 01/01/2012 - "Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia."
2.	Sepsis (Septicemia) 01/01/2012 - "These findings suggest that carboetomidate could be a useful alternative to etomidate for maintaining anesthesia for a prolonged period of time in patients with sepsis." 01/01/2012 - "Compared with etomidate, carboetomidate produces less suppression of adrenocortical function and smaller increases in proinflammatory cytokine production in an endotoxemia model of sepsis. "
3.	Critical Illness (Critically Ill) 03/01/2010 - "Carboetomidate is a promising new sedative hypnotic for potential use in critically ill patients in whom adrenocortical suppression is undesirable."

Related Drugs and Biologics

1.	Cytokines
2.	Etomidate
3.	Pyrroles
4.	Hypnotics and Sedatives (Sedatives)

Related Therapies and Procedures

1.	Anesthesia