4- (3- chloro- 2- fluorophenoxy)- 1- ((6- (1,3- thiazol- 2- ylamino)pyridin to 2-yl)methyl) cyclohexanecarboxylic acid

07/01/2014 - "Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies."
07/01/2014 - "We sought to assess the preclinical efficacy of MK-5108 in a panel of non-small-cell lung cancer cell lines as a single agent and in combination with cisplatin and docetaxel. "

11/01/2021 - "MK-5108, a potent and highly selective AURKA inhibitor, was shown to exhibit anti-cancer activity in recent preclinical and clinical studies. "
07/01/2014 - "MK-5108 is a potent inhibitor of Aurora A kinase that has shown preclinical potent activity in malignancies of breast, cervical, colon, ovarian, and pancreatic origin. "
06/15/2012 - "Gavage of an orthotopic ULMS model with MK-5108 at 30 or 60 mg/kg decreased the number and size of tumor implants compared with sham-fed controls. "
01/01/2010 - "MK-5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. "
01/01/2010 - "MK-5108 is currently tested in clinical trials and offers a new therapeutic approach to combat human cancers as a single agent or in combination with existing taxane therapies."

11/01/2021 - "In the present study, we investigated the role of MK-5108 in renal fibrosis employing animal and cell models. "
11/01/2021 - "MK-5108 is a potential therapeutic agent for treatment of renal fibrosis in CKD."
11/01/2021 - "Post treatment with MK-5108 at the 3rd day after UUO remarkably alleviated renal fibrosis, possibly by inhibiting the proliferation and activation of fibroblasts and suppressing the phenotypic transition of renal cells. "
11/01/2021 - "In this study, inhibition of AURKA by MK-5108 markedly attenuated renal fibrosis. "
11/01/2021 - "Blocking AURKA with MK-5108 attenuates renal fibrosis in chronic kidney disease."

07/01/2014 - "MK-5108 induced G2/M accumulation, polyploidy, and apoptosis (increased sub-G1/PARP cleavage). "
01/01/2018 - "The Aurora kinase A inhibitor MK-5108 did not significantly increase the percentage of polyploid cells at any of the doses tested in either cell line. "
07/01/2011 - "The intracellular changes associated with MK-5108 treatment are: (1) polyploidy and cell cycle arrest; (2) inhibition of NFκB activity; (3) decreased cytokine production; and (4) nuclear accumulation of IκBα. "

12/01/2013 - "Most importantly, we show, that MK-5108 specific aurora A kinase inhibitor decreases neuroblastoma cell survival, and when used in combination with the mAb, significantly potentiates cytotoxicity against IMR-32, CHP-134, and LA-N-5 neuroblastoma cells in vitro. "
10/01/2018 - "GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells."
10/01/2018 - "The process of autophagy and its role in survival of human neuroblastoma cell cultures was studied upon addition of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (14G2a mAb) and an aurora A kinase specific inhibitor, MK-5108. "