GGTI-2133

an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma

Also Known As:

N-(4-(imidazol-4-yl)methylamino)-2-(1-(naphthyl)benzolyl)leucine trifluoroacetate salt

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Thorlacius, Henrik: 4 articles (11/2013 - 02/2013)
2.	Hisa, Hiroaki: 2 articles (04/2014 - 02/2008)
3.	Mutoh, Junpei: 2 articles (04/2014 - 02/2008)
4.	Ohsawa, Masahiro: 2 articles (04/2014 - 02/2008)
5.	Syk, Ingvar: 2 articles (11/2013 - 02/2013)
6.	Jeppsson, Bengt: 2 articles (03/2013 - 02/2013)
7.	Rahman, Milladur: 2 articles (03/2013 - 02/2013)
8.	Abdullah, Marwan Ibrahim: 1 article (01/2017)
9.	Abed, Mohammed Najim: 1 article (01/2017)
10.	Richardson, Alan: 1 article (01/2017)

Related Diseases

1.	Morphine Dependence 08/01/2013 - "Therefore, the present study investigated the effect of GGTI-2133 and FTI-276 on propagation of morphine dependence and resultant withdrawal signs in vivo, in sub-chronic morphine mouse model, and in vitro, in isolated rat ileum. " 08/01/2013 - "It is concluded that GGTI-2133 and FTI-276 attenuate the propagation of morphine dependence and reduce withdrawal signs possibly by a geranylgeranyl transferase; farnesyltransferase activation pathway linked mechanisms potentially in an interdependent manner."
2.	Edema (Dropsy) 02/15/2013 - "Administration of GGTI-2133 markedly decreased CLP-induced infiltration of neutrophils, edema, and tissue injury in the lung. " 03/01/2013 - "GGTI-2133 reduced M1 protein-provoked infiltration of neutrophils, edema, and tissue injury in the lung. " 09/01/2013 - "Pretreatment with GGTI-2133 reduced plasma amylase levels, pancreatic neutrophil recruitment, hemorrhage, and edema formation in taurocholate-evoked pancreatitis. "
3.	Hyperalgesia 04/03/2014 - "Intrathecal treatment with GGTI-2133 also attenuated the mechanical allodynia in partial sciatic nerve-ligated mice. " 04/03/2014 - "Intrathecal treatment with a geranylgeranyl transferase I inhibitor GGTI-2133, but not with a farnesyl transferase inhibitor FTI-277, dose-dependently blocked the thermal hyperalgesia in partial sciatic nerve-ligated mice. " 02/01/2008 - "Intrathecal pretreatment with a geranylgeranyl transferase I inhibitor GGTI-2133 (0.001-1.0 nmol) or a ROCK inhibitor Y27632 (0.001-1.0 nmol) completely blocked the mevalonate-induced thermal hyperalgesia. "
4.	Asthma (Bronchial Asthma) 10/01/2009 - "GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma." 11/01/2009 - "To test this hypothesis, we investigated the effect of a geranylgeranyltransferase inhibitor, GGTI-2133, on antigen-induced BSM hyperresponsiveness by using mice with experimental asthma. " 10/01/2009 - "To test the hypothesis, the effects of GGTI-2133, a direct inhibitor of geran ylgeranyltransferase (GGTase), on antigen-induced airway inflammation were investigated in a murine model of allergic bronchial asthma. "
5.	Pancreatitis 09/01/2013 - "Male C57BL/6 mice were treated with a geranylgeranyltransferase inhibitor GGTI-2133 (20 mg/kg) prior to induction of pancreatitis by infusion of taurocholate into the pancreatic duct. " 09/01/2013 - "Pretreatment with GGTI-2133 reduced plasma amylase levels, pancreatic neutrophil recruitment, hemorrhage, and edema formation in taurocholate-evoked pancreatitis. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	FTI 276
3.	Transferases
4.	Antigens
5.	Farnesyltranstransferase (Farnesyltransferase)
6.	Geranyltranstransferase
7.	Taurocholic Acid (Sodium Taurocholate)
8.	Proteins (Proteins, Gene)
9.	Mevalonic Acid (Mevalonate)
10.	Amylases