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NSC746364

Antineoplastic

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Anthracenes: 12
        Anthrones: 12
        Anthraquinones: 788
        NSC746364: 1
- Quinones: 434
  - Anthraquinones: 788
    - NSC746364: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - Anthrones: 12
      - Anthraquinones: 788
        NSC746364: 1

Experts

1.	Chen, Tsung-Chih: 1 article (01/2014)
2.	Chung, Yun-Lung: 1 article (01/2014)
3.	Huang, Hsu-Shan: 1 article (01/2014)
4.	Lin, Wen-Hsin: 1 article (01/2014)
5.	Liou, Wei-Hung: 1 article (01/2014)
6.	Pan, Chun-Hsu: 1 article (01/2014)
7.	Sheu, Ming-Jyh: 1 article (01/2014)
8.	Wu, Chieh-Hsi: 1 article (01/2014)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "Consequently, our results indicated that NSC746364 may have therapeutic potential as a chemotherapy for non-small-cell lung cancers." 01/01/2014 - "NSC746364, a G-quadruplex-stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of the ATR/Chk1-dependent pathway." 01/01/2014 - "Our study suggested that NSC746364 induced cell cycle arrest at the G2/M phase and triggers programming cell death on A549 human lung cancer cells, whose effects are modulated through the activation of the ATR/Chk1 pathway, the downregulation of cyclin B1 expression, and the activation of caspase-3. "
2.	Adenocarcinoma of Lung 01/01/2014 - "The goal of this study was to investigate the molecular mechanisms of NSC746364 on the A549 human lung adenocarcinoma cell line. "
3.	Neoplasms (Cancer) 01/01/2014 - "NSC746364, a novel G-quadruplex-stabilizing agent, has been found to have cytotoxic effects on various cancer cells. "

Related Drugs and Biologics

1.	Cyclin B1
2.	Caspase 3 (Caspase-3)
3.	Excipients (Suspending Agents)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)