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spirohexenolide A

structure in first source

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - spirohexenolide A: 2

Experts

1.	Burkart, Michael D: 1 article (12/2009)
2.	DiPasquale, Antonio G: 1 article (12/2009)
3.	Hammons, Justin C: 1 article (12/2009)
4.	Jones, Brian D: 1 article (12/2009)
5.	Kang, MinJin: 1 article (12/2009)
6.	La Clair, James J: 1 article (12/2009)
7.	Mandel, Alexander L: 1 article (12/2009)
8.	Rheingold, Arnold L: 1 article (12/2009)

Related Diseases

1.

Neoplasms (Cancer)

12/04/2009 - "Time lapse imaging studies indicated that spirohexenolide A (1) was readily taken up by tumor cells, appearing through the cell immediately after dosing and subcellularly localizing in the lysosomes. "
12/04/2009 - "Spirohexenolide A (1) inhibited tumor cell growth with GI(50) values spanning from 0.1 to 17 microM across the NCI 60 cell line panel. "
11/21/2023 - "Our in vitro bioassay studies reveal that both spirohexenolides are cytotoxic against a panel of human cancer cells with IC50 1.2-13.3 μM and spirohexenolide A is consistently more potent (up to 3 times) than spirohexenolide B, suggesting the importance of alcohol for their bioactivity and for medicinal chemistry development."

Related Drugs and Biologics

1.	spirohexenolide B