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2-benzo(1,3)dioxol-5-ylthiazole

Subscribe to New Research on 2-benzo(1,3)dioxol-5-ylthiazole

has an anti-fibrotic effect; structure in first source

Also Known As:

CW 209292; CW-209292; CW209292

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Sulfur Compounds: 135
  - Thiazoles: 23
    - 2-benzo(1,3)dioxol-5-ylthiazole: 1
Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Thiazoles: 23
      - 2-benzo(1,3)dioxol-5-ylthiazole: 1
  - Dioxoles
    - Benzodioxoles: 3
      - 2-benzo(1,3)dioxol-5-ylthiazole: 1
- 2-Ring Heterocyclic Compounds
  - Benzodioxoles: 3
    - 2-benzo(1,3)dioxol-5-ylthiazole: 1

Experts

1.	Kim, Dae-Yong: 1 article (08/2009)
2.	Kim, Dae-Hoon: 1 article (08/2009)
3.	Oh, Se-Woong: 1 article (08/2009)
4.	Ha, Jong-Ryul: 1 article (08/2009)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2009 - "Furthermore, tumor growth factor (TGF)-beta1 mRNA expression was increased in DMN-treated rats, whereas CW209292 treatment prevented these increases. "
2.	Inflammation 08/01/2009 - "CW209292 also significantly reduced hepatic hydroxyproline content as well as hepatic fibrosis and inflammation in histological examination. "
3.	Fibrosis (Cirrhosis) 08/01/2009 - "CW209292 also significantly reduced hepatic hydroxyproline content as well as hepatic fibrosis and inflammation in histological examination. " 08/01/2009 - "These results suggest that CW209292 exhibits anti-fibrotic effects in Sprague Dawley rats with DMN-induced hepatic fibrosis by blocking the mRNA expression of TGF-beta1 and subsequent inhibition of the proliferation of hepatic stellate cells." 08/01/2009 - "Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats."

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Messenger RNA (mRNA)
3.	Hydroxyproline (4 Hydroxyproline)
4.	Dimethylnitrosamine (Nitrosodimethylamine)
5.	1,3-benzodioxole (MDB)