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N- (2- dimethylaminoethyl)- 4,8- dihydrobenzo(1,2- b,4,5- b')dithiophene- 2- carboxamide

an antileukemia agent; structure in first source

Also Known As:

ITR 284; ITR-284; ITR284

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - N-(2-dimethylaminoethyl)-4,8-dihydrobenzo(1,2-b,4,5-b')dithiophene-2-carboxamide: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - N-(2-dimethylaminoethyl)-4,8-dihydrobenzo(1,2-b,4,5-b')dithiophene-2-carboxamide: 3

Experts

1.	Wen, Yen-Fang: 3 articles (03/2017 - 02/2010)
2.	Yang, Jai-Sing: 3 articles (03/2017 - 02/2010)
3.	Lu, Chi-Cheng: 2 articles (03/2017 - 05/2013)
4.	Kuo, Sheng-Chu: 2 articles (05/2013 - 02/2010)
5.	Lin, Chia-An: 1 article (03/2017)
6.	Tsai, Fuu-Jen: 1 article (03/2017)
7.	Tsai, Shih-Chang: 1 article (03/2017)
8.	Fushiya, Shinji: 1 article (05/2013)
9.	Lai, Kuang-Chi: 1 article (05/2013)
10.	Liao, Yu-Ren: 1 article (05/2013)

Related Diseases

1.	Leukemia 02/01/2010 - "In this study, the underlying molecular mechanisms in vitro and anti-leukemia activity in vivo of ITR-284 were investigated. " 02/01/2010 - "These results revealed that ITR-284 acted against both HL-60 and WEHI-3 in vitrovia both intrinsic and extrinsic apoptotic signaling pathways, and exhibited an anti-leukemic effect in a WEHI-3 orthotopic mice model of leukemia." 02/01/2010 - "In addition, the anti-leukemia effects of ITR-284 in vivo were further evaluated in BALB/c mice inoculated with WEHI-3 cells. " 02/01/2010 - "ITR-284 reduced the cell viability and induced apoptosis in HL-60 and WEHI-3 leukemia cells. " 02/01/2010 - "ITR-284, a potent anti-leukemia agent of carboxamide derivative, has been shown to inhibit the proliferation of leukemia cells. "
2.	Colorectal Neoplasms (Colorectal Cancer) 05/01/2013 - "In this study, we investigated the antiproliferative effects and apoptotic induction of ITR-284 on various types of human hepatocellular and colorectal cancer cells in vitro. " 05/01/2013 - "However, there are no reports showing that ITR-284 inhibits human hepatocellular and colorectal cancer cells. " 05/01/2013 - "ITR-284 reduced the cell viability in human hepatocellular cancer cells (Hep G2, Hep 3B, SK-HEP-1 and J5) and colorectal cancer cells (HT 29, COLO 205, HCT 116 and SW 620). " 05/01/2013 - "The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells."
3.	Neoplasms (Cancer) 05/01/2013 - "The growth inhibition effect of ITR-284 on cancer cells was evaluated by thiazolyl blue tetrazolium bromide (MTT) assay. "
4.	Lung Neoplasms (Lung Cancer) 03/01/2017 - "We showed that ITR-284 inhibited human lung cancer A549 cells using the thiazolyl blue tetrazolium bromide (MTT) assay and evoked apoptosis via the cell cycle distribution at S phase arrest. "
5.	Liver Neoplasms (Liver Cancer) 05/01/2013 - "ITR-284 reduced the cell viability in human hepatocellular cancer cells (Hep G2, Hep 3B, SK-HEP-1 and J5) and colorectal cancer cells (HT 29, COLO 205, HCT 116 and SW 620). "

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