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N- 1- (2- (1- (tert- butyl- 4- (2,4- difluorophenyl)pyrrolidin- 3- yl)- 5- chlorophenyl)ethyl)acetamide

putative antiobesity agent

Also Known As:

MK 0493; MK-0493; MK0493

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - N-1-(2-(1-(tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)-5-chlorophenyl)ethyl)acetamide: 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        N-1-(2-(1-(tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)-5-chlorophenyl)ethyl)acetamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - N-1-(2-(1-(tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)-5-chlorophenyl)ethyl)acetamide: 1

Experts

1.	Amatruda, J: 1 article (12/2009)
2.	Blundell, J: 1 article (12/2009)
3.	Bray, G A: 1 article (12/2009)
4.	Cosgrove, D: 1 article (12/2009)
5.	Fujioka, K: 1 article (12/2009)
6.	Gottesdiener, K: 1 article (12/2009)
7.	Gumbiner, B: 1 article (12/2009)
8.	Han, T H: 1 article (12/2009)
9.	Herman, G A: 1 article (12/2009)
10.	Heymsfield, S B: 1 article (12/2009)

Related Diseases

1.

Weight Loss (Weight Reduction)

12/01/2009 - "MK-0493 was associated with modest weight reduction from baseline but had only small, statistically insignificant effects relative to placebo after 12 weeks in a fixed-dose study and also after 18 weeks of stepped-titration dosing. "
12/01/2009 - "Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy."

Related Drugs and Biologics

1.	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)