resolvin D2

structure in first source; a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance

Also Known As:

Networked: 54 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Serhan, Charles N: 6 articles (01/2018 - 10/2009)
2.	Irimia, Daniel: 4 articles (01/2018 - 01/2013)
3.	Levy, Bruce D: 3 articles (01/2021 - 01/2017)
4.	Yu, Yong-Ming: 3 articles (01/2018 - 06/2013)
5.	Heyman, Oded: 2 articles (11/2022 - 01/2018)
6.	Mizraji, Gabriel: 2 articles (11/2022 - 01/2018)
7.	Wilensky, Asaf: 2 articles (11/2022 - 01/2018)
8.	Zuo, Gang: 2 articles (10/2022 - 01/2018)
9.	Miao, Zhijuan: 2 articles (01/2022 - 01/2021)
10.	Schultzberg, Marianne: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Inflammation (Inflammations) 10/27/2023 - "Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation." 04/05/2023 - "Inflammation-resolution is in part mediated by Resolvins, including Resolvin D2 (RvD2). " 11/01/2018 - "Collectively, these results indicate that Alox15-mediated production of resolvin D2 is required to maintain skin integrity by suppressing dermal inflammation." 11/01/2018 - "Treatment with resolvin D2 reduced skin inflammation in Alox15 KO mice. " 01/01/2017 - "Novel Resolvin D2 Receptor Axis in Infectious Inflammation."
2.	Sepsis (Septicemia) 10/29/2009 - "Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis." 01/01/2022 - "Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection." 01/01/2021 - "These findings indicate that resolvin D1 and resolvin D2 signaling for antiinflammation and resolution are uncoupled from leukocyte activation in early sepsis and suggest that indicators of diminished resolution signaling correlate with clinical disease severity." 01/01/2021 - "In nanomolar concentrations, resolvin D1 and resolvin D2 partially reversed sepsis-induced changes in leukocyte activation and function. " 01/01/2021 - "Neutrophils and monocytes were isolated from healthy subjects and patients with sepsis by inertial microfluidics and resolvin D1 and resolvin D2 receptor expression determined by flow cytometry. "
3.	Infections 07/27/2015 - "Identification of resolvin D2 receptor mediating resolution of infections and organ protection." 11/01/2022 - "Excessive inflammatory response to infection in experimental peri-implantitis: Resolution by Resolvin D2." 01/01/2022 - "Resolvin D2 induces anti-microbial mechanisms in a model of infectious peritonitis and secondary lung infection." 01/01/2022 - "Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection." 01/01/2022 - "We examined if an SPM, Resolvin D2 (RvD2) could promote host defense in a 2-hit mouse model of cecal ligation and puncture (CLP) sepsis and secondary Pseudomonas aeruginosa lung infection. "
4.	Coinfection 01/01/2022 - "Specialized Pro-resolving Mediators (SPMs) such as resolvin D2 (RvD2) have been shown to be beneficial for inflammation/infection resolution in animal models of sepsis but in vivo mechanisms by which RvD2 may promote bacterial clearance and/or attenuate deleterious effects of a secondary infection have not been fully established. "
5.	Gliosis 01/01/2017 - "This was associated with a significant elevation in the plasma levels of resolvin D2 and a significant reduction in astrogliosis in the spinal cord in the monosodium iodoacetate-induced OA rat model. "

Related Drugs and Biologics

1.	Iodoacetic Acid
2.	resolvin D1
3.	Lipids
4.	Docosahexaenoic Acids
5.	Inflammasomes
6.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
7.	Dextran Sulfate
8.	Sulfonic Acids
9.	Reserpine (Serpasil)
10.	Fatty Acids (Saturated Fatty Acids)

Related Therapies and Procedures

1.	Ligation
2.	Punctures
3.	Thoracotomy
4.	Spinal Injections