peperomin E

07/01/2021 - "A DU145 cell xenograft tumor mouse model was used to evaluate the efficacy of peperomin E in vivo. "
07/01/2021 - "The results showed that peperomin E significantly inhibited the proliferation of DU145 cells in vitro and reduced the weight and volume of tumors in vivo. "
07/01/2021 - "Peperomin E was first isolated from Peperomia dindygulensis, an anticarcinogenic herb, and exhibited anticancer activity in many cancer cell lines. "
10/01/2016 - "Peperomin E inhibited tumor growth in A549 xenograft BALB/c nude mice without significant secondary adverse effects, indicating that it may be safely used to treat NSCLC. "
05/01/2006 - "Compound 7 and peperomin E (12) exhibited inhibitory activity against a liver tumor cell (HepG2) with IC(50) values of 22.3 and 12.1 microM. "

10/01/2016 - "Subsequent experiments verified that peperomin E decreased DNMT1 activity and expression, thereby decreasing global methylation and reactivating the epigenetically silenced tumor suppressor genes including RASSF1A, APC, RUNX3, and p16INK4, which in turn activates their mediated pro-apoptotic and cell cycle regulatory signaling pathways in lung cancer cells. "
10/01/2016 - "In this study, we investigated the antitumor effects of peperomin E, a secolignan isolated from Peperomia dindygulensis, a frequently used Chinese folk medicine for lung cancer treatment. "
10/01/2016 - "Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells by inhibition of DNA methyltransferase."

07/01/2021 - "These results suggest that the combination of peperomin E treatment and autophagic inhibition has potential for the treatment of prostate cancer."
07/01/2021 - "To date, it is unknown whether peperomin E has an effect on human prostate cancer DU145 cells in vitro and in vivo. "
07/01/2021 - "Peperomin E Induces Apoptosis and Cytoprotective Autophagy in Human Prostate Cancer DU145 Cells In Vitro and In Vivo."
04/15/2019 - "The Anti-Proliferation, Cycle Arrest and Apoptotic Inducing Activity of Peperomin E on Prostate Cancer PC-3 Cell Line."
04/15/2019 - "Previous investigations demonstrated that peperomin E showed potential antitumor activity in some cancer lines, but it is unclear whether peperomin E has an effect on prostate cancer cell lines. "

01/01/2020 - "Corrigendum to "The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo" [Phytomedicine 23 (2016) 818-827]."
07/15/2016 - "The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo."

09/01/2018 - "Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE-/-) mice through reducing inflammation via the suppression of NLRP3 signaling pathway."