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CX 3543

inhibits rRNA biogenesis; structure in first source

Also Known As:

CX-3543; CX3543

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Benzoxazines: 58
      - CX 3543: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        CX 3543: 3
    - Benzoxazines: 58
      - CX 3543: 3

Experts

1.	Xu, Bao-Hong: 1 article (01/2018)
2.	Yao, Yu-Xia: 1 article (01/2018)
3.	Zhang, Yan: 1 article (01/2018)
4.	Anderes, Kenna: 1 article (10/2009)
5.	Bliesath, Josh: 1 article (10/2009)
6.	Drygin, Denis: 1 article (10/2009)
7.	Ho, Caroline B: 1 article (10/2009)
8.	Lim, John K C: 1 article (10/2009)
9.	Lin, Amy: 1 article (10/2009)
10.	O'Brien, Sean: 1 article (10/2009)

Related Diseases

1.	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/01/2009 - "CX-3543 is the first G-quadruplex interactive agent to enter human clinical trials, and it is currently under evaluation against carcinoid/neuroendocrine tumors in a phase II clinical trial."
2.	Neuroendocrine Carcinoma 01/01/2018 - "A small-molecule compound CX3543 (Quarfloxin) selectively targeting Myc G-quadruplexes has entered phase II clinical trials for neuroendocrine carcinomas. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/2018 - "Our study demonstrated that CX3543 could inhibit the progression of colon cancer by downregulating CCAT1 expression and might be a potential drug for the treatment of colon cancer." 01/01/2018 - "The aim of the study was to explore the relationship between CX3543, CCAT1, and cell apoptosis in colon cancer cells. " 01/01/2018 - "CX-3543 Promotes Cell Apoptosis through Downregulation of CCAT1 in Colon Cancer Cells."
4.	Carcinoid Tumor (Carcinoid) 10/01/2009 - "CX-3543 is the first G-quadruplex interactive agent to enter human clinical trials, and it is currently under evaluation against carcinoid/neuroendocrine tumors in a phase II clinical trial."
5.	Neoplasms (Cancer) 01/01/2018 - "In vivo results showed that CX3543 inhibited the xenograft tumor growth of rats through downregulation of CCAT1. " 10/01/2009 - "Herein, we describe CX-3543, a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells. "

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