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methyl 2-(2-fluorobenzamido)benzoate

a phosphodiesterase inhibitor; structure in first source

Also Known As:

DSM RX78; DSM-RX78

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Hsieh, Pei-Wen: 2 articles (03/2013 - 10/2009)
2.	Fang, Jia-You: 1 article (03/2013)
3.	Huang, Yaw-Bin: 1 article (03/2013)
4.	Liu, Yi-Ting: 1 article (03/2013)
5.	Pan, Tai-Long: 1 article (03/2013)
6.	Wang, Han-Hsiang: 1 article (03/2013)
7.	Chang, Yi-Ju: 1 article (10/2009)
8.	Chung, Pei-Jen: 1 article (10/2009)
9.	Hwang, Tsong-Long: 1 article (10/2009)
10.	Kuo, Liang-Mou: 1 article (10/2009)

Related Diseases

1.	Lung Injury 10/15/2009 - "Also, our findings show that DSM-RX78 attenuates hemorrhagic shock-induced lung injury in rats." 03/01/2013 - "The aim of this study was to determine the pharmacokinetic profile, biodistribution and toxicity of ethyl 2-(2-fluorobenzamido)benzoate (EFB-1) and methyl 2-(2-fluorobenzamido)benzoate (DSM-RX 78), two phosphodiesterase IV inhibitors, which potently attenuate haemorrhagic shock-induced lung injury in rat. " 10/15/2009 - "DSM-RX78, a new phosphodiesterase inhibitor, suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats." 10/15/2009 - "This research investigated the effects of a semisynthetic 2-benzoylaminobenzoic acid derivative, methyl 2-(2-fluorobenzamido)benzoate (DSM-RX78), on superoxide anion (O(2)(-)) production in formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP)-activated human neutrophils, and on lung injury in Sprague-Dawley rats subjected to trauma-hemorrhage. "
2.	Shock 03/01/2013 - "The aim of this study was to determine the pharmacokinetic profile, biodistribution and toxicity of ethyl 2-(2-fluorobenzamido)benzoate (EFB-1) and methyl 2-(2-fluorobenzamido)benzoate (DSM-RX 78), two phosphodiesterase IV inhibitors, which potently attenuate haemorrhagic shock-induced lung injury in rat. "
3.	Wounds and Injuries (Trauma) 10/15/2009 - "On the other hand, administration of DSM-RX78 significantly attenuated the increase in myeloperoxidase activity and edema in the lung, as well as protein concentrations in bronchoalveolar lavage fluid in rats after trauma-hemorrhagic shock. " 10/15/2009 - "This research investigated the effects of a semisynthetic 2-benzoylaminobenzoic acid derivative, methyl 2-(2-fluorobenzamido)benzoate (DSM-RX78), on superoxide anion (O(2)(-)) production in formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP)-activated human neutrophils, and on lung injury in Sprague-Dawley rats subjected to trauma-hemorrhage. "
4.	Hemorrhagic Shock 10/15/2009 - "Also, our findings show that DSM-RX78 attenuates hemorrhagic shock-induced lung injury in rats." 10/15/2009 - "DSM-RX78, a new phosphodiesterase inhibitor, suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats." 10/15/2009 - "On the other hand, administration of DSM-RX78 significantly attenuated the increase in myeloperoxidase activity and edema in the lung, as well as protein concentrations in bronchoalveolar lavage fluid in rats after trauma-hemorrhagic shock. "
5.	Hemorrhage 10/15/2009 - "This research investigated the effects of a semisynthetic 2-benzoylaminobenzoic acid derivative, methyl 2-(2-fluorobenzamido)benzoate (DSM-RX78), on superoxide anion (O(2)(-)) production in formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP)-activated human neutrophils, and on lung injury in Sprague-Dawley rats subjected to trauma-hemorrhage. "

Related Drugs and Biologics

1.	Type 4 Cyclic Nucleotide Phosphodiesterases
2.	Superoxides (Superoxide)
3.	Proteins (Proteins, Gene)
4.	Phosphodiesterase Inhibitors
5.	Phenylalanine (L-Phenylalanine)
6.	Peroxidase (Myeloperoxidase)
7.	Acids