N,N- diethyl- 3- hydroxy- 4- (spiro(chromene- 2,4'- piperidine)- 4- yl)benzamide

putative analgesic; structure in first source

Also Known As:

ADL 5747; ADL-5747; ADL5747

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - N,N-diethyl-3-hydroxy-4-(spiro(chromene-2,4'-piperidine)-4-yl)benzamide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - N,N-diethyl-3-hydroxy-4-(spiro(chromene-2,4'-piperidine)-4-yl)benzamide: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - N,N-diethyl-3-hydroxy-4-(spiro(chromene-2,4'-piperidine)-4-yl)benzamide: 3
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - N,N-diethyl-3-hydroxy-4-(spiro(chromene-2,4'-piperidine)-4-yl)benzamide: 3

Experts

1.	Dolle, Roland E: 2 articles (09/2012 - 09/2009)
2.	Le Bourdonnec, Bertrand: 2 articles (09/2012 - 09/2009)
3.	Little, Patrick J: 2 articles (09/2012 - 09/2009)
4.	Windh, Rolf T: 2 articles (09/2012 - 09/2009)
5.	Spahn, Viola: 1 article (02/2017)
6.	Stein, Christoph: 1 article (02/2017)
7.	Gavériaux-Ruff, Claire: 1 article (09/2012)
8.	Kieffer, Brigitte L: 1 article (09/2012)
9.	Nozaki, Chihiro: 1 article (09/2012)
10.	Reiss, David: 1 article (09/2012)

Related Diseases

1.	Pain (Aches) 09/24/2009 - "Further structure activity relationship exploration has led to the discovery of ADL5747 (36), which is approximately 50-fold more potent than 4 in an animal model of inflammatory pain. " 02/01/2017 - "ADL5859 and ADL5747 entered clinical trials and successfully passed phase I. However, in phase II studies the primary endpoint (pain reduction) was not met and further investigation was terminated. " 09/01/2012 - "In conclusion, both ADL5859 and ADL5747 showed efficient pain-reducing properties in the two models of chronic pain. " 09/01/2012 - "We tested analgesic effects of ADL5859 and ADL5747 in mice by using mechanical sensitivity measures in both complete Freund's adjuvant and sciatic nerve ligation pain models. " 09/24/2009 - "Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747)."
2.	Chronic Pain 09/01/2012 - "In conclusion, both ADL5859 and ADL5747 showed efficient pain-reducing properties in the two models of chronic pain. " 09/01/2012 - "N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5859) and N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5747) are novel δ-opioid agonists that show good oral bioavailability and analgesic and antidepressive effects in the rat and represent potential drugs for chronic pain treatment. "
3.	Neuralgia (Stump Neuralgia) 09/01/2012 - "Both ADL5859 and ADL5747, and the prototypical δ agonist 4-[(R)-[(2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethyl-benzamide (SNC80) as a control, significantly reduced inflammatory and neuropathic pain. "

Related Drugs and Biologics

1.	N,N- diethyl- 4- (5- hydroxyspiro(chromene- 2,4'- piperidine)- 4- yl)benzamide
2.	Benzopyrans
3.	benzamide
4.	piperidine
5.	delta Opioid Receptors (delta Opioid Receptor)
6.	Freund's Adjuvant
7.	Opioid Analgesics (Opioids)
8.	Analgesics (Analgesic Drugs)
9.	4- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- methoxybenzyl)- N,N- diethylbenzamide

Related Therapies and Procedures

1.	Ligation