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APD791

serotonin antagonist; structure in first source

Also Known As:

3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide; APD 791

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adams, John: 1 article (06/2010)
2.	Al-Shamma, Hussien: 1 article (06/2010)
3.	Casper, Martin D: 1 article (06/2010)
4.	Chen, Weichao: 1 article (06/2010)
5.	Choi, Jin-Sun Karoline: 1 article (06/2010)
6.	Connolly, Daniel T: 1 article (06/2010)
7.	Decaire, Marc: 1 article (06/2010)
8.	Dosa, Peter I: 1 article (06/2010)
9.	Feichtinger, Konrad: 1 article (06/2010)
10.	Frazer, John: 1 article (06/2010)

Related Diseases

1.	Thrombosis (Thrombus) 02/01/2010 - "5HT2A receptor inhibition with APD791, even when initiated after the onset of recurrent thrombosis, improves coronary patency in the in vivo canine model." 02/01/2010 - "APD791 attenuated recurrent thrombosis, irrespective of the time of treatment: in both protocols, flow-time area (index of coronary patency; normalized to baseline coronary flow) averaged 58-59% (P<0.01) following administration of APD791 vs. 21-28% in saline controls. " 02/01/2010 - "Protocol 2 was similar, except that: (i) treatment with APD791 or saline was begun 1 h after the onset of recurrent thrombosis; (ii) template bleeding time was measured; and (iii) blood samples were obtained for in vitro flow cytometric assessment of platelet responsiveness to serotonin. " 06/10/2010 - "Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis."
2.	Hemorrhage 02/01/2010 - "Moreover, the in vivo antithrombotic effect of APD791 was not accompanied by increased bleeding, but was associated with significant and selective inhibition of serotonin-mediated platelet activation. "

Related Drugs and Biologics

1.	APD791
2.	Serotonin (5 Hydroxytryptamine)