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4'-methoxy-3',5,7-trihydroxyisoflavone

structure in first source

Also Known As:

4776B compound; pratensein

Networked: 4 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        4'-methoxy-3',5,7-trihydroxyisoflavone: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        4'-methoxy-3',5,7-trihydroxyisoflavone: 4

Experts

1.	Huang, Quanfang: 2 articles (04/2015 - 03/2015)
2.	Lin, Xing: 2 articles (04/2015 - 03/2015)
3.	Lu, Zhongpeng: 2 articles (04/2015 - 03/2015)
4.	Deng, Wenjing: 1 article (04/2022)
5.	Teng, Junfang: 1 article (04/2022)
6.	Wang, Rui: 1 article (04/2022)
7.	Wei, Yamin: 1 article (04/2022)
8.	Liang, Chunhong: 1 article (04/2015)
9.	Lin, Jun: 1 article (04/2015)
10.	Tan, Shimei: 1 article (04/2015)

Related Diseases

1.	Cognitive Dysfunction 03/01/2015 - "The results showed that pratensein treatment significantly protected against Aβ1-42-induced cognitive impairments, as evidenced by the improvement in learning and memory and the attenuation of neuronal degeneration and apoptosis in hippocampus. " 04/10/2015 - "This study was designed to investigate the protective effect of pratensein against cognitive impairment induced by amyloid beta (1-42) (Aβ1-42) in rats. " 03/01/2015 - "The protective effect of pratensein was evaluated using a cognitive impairment model induced by injecting amyloid beta (1-42) (Aβ1-42) into the bilateral hippocampus of rats. " 04/10/2015 - "Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels."
2.	Alzheimer Disease (Alzheimer's Disease) 03/01/2015 - "In summary, our study indicated that pratensein may have a likely protective effect against Alzheimer's disease (AD) via improving synaptic plasticity and increasing cholinesterase activity. "
3.	Memory Disorders (Memory Loss) 04/10/2015 - "Our findings demonstrated that treatment with pratensein ameliorated learning and memory deficits in Aβ1-42 rat model of AD. "
4.	Hyperlipidemias (Hyperlipidemia) 07/01/1979 - "In Triton-WR1339-induced hyperlipidemia in male albino rats, biochanin A, formononetin and pratensein showed hypolipidemic activity, while diadzein did not, when these isoflavones were administered as individual compounds by gastric intubation."
5.	Gliosis 04/10/2015 - "Moreover, the over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 were significantly reduced following administration of pratensein. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Amyloid (Amyloid Fibrils)
3.	Amyloid beta-Peptides
4.	Cholinesterases (Cholinesterase)
5.	Neuroprotective Agents
6.	Isoflavones
7.	formononetin
8.	daidzein
9.	biochanin A