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3-oxocycloart-22,24-dien-26-oic acid

constituent of propolis from Myanmar with preferential cytotoxicity against a human pancreatic cancer cell line; structure in first source

Also Known As:

(22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - 3-oxocycloart-22,24-dien-26-oic acid: 1

Experts

1.	Awale, Suresh: 1 article (07/2009)
2.	Esumi, Hiroyasu: 1 article (07/2009)
3.	Kadota, Shigetoshi: 1 article (07/2009)
4.	Li, Feng: 1 article (07/2009)
5.	Tezuka, Yasuhiro: 1 article (07/2009)
6.	Zhang, Hongyan: 1 article (07/2009)

Related Diseases

1.

Pancreatic Neoplasms (Pancreatic Cancer)

07/01/2009 - "A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC(50) value of 9.3 microg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). "

Related Drugs and Biologics

1.	Flavanones
2.	Triterpenes
3.	Propolis (Bee Bread)
4.	3- oxo- 27,28- dihydroxycycloart- 24- en- 26- oic acid
5.	cycloartane