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filicene

Antinociceptive from Adiantum cuneatum (Adiantaceae) leaves; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - filicene: 2

Experts

1.	Ardenghi, J V: 1 article (07/2009)
2.	Bresciani, L F: 1 article (07/2009)
3.	Cechinel-Filho, V: 1 article (07/2009)
4.	De Souza, M M: 1 article (07/2009)
5.	Delle Monache, F: 1 article (07/2009)
6.	Mora, T C: 1 article (07/2009)
7.	Pereira, M A: 1 article (07/2009)
8.	Yunes, R A: 1 article (07/2009)
9.	Bresciani, Louisiane F V: 1 article (03/2003)
10.	Cechinel-Filho, Valdir: 1 article (03/2003)

Related Diseases

1.

07/01/2009 - "In the present study, we describe the antinociceptive effect of filicene, a triterpene isolated from Adiantum cuneatum (Adiantaceae) leaves, in several models of pain in mice. "
07/01/2009 - "Filicene also produced dose-related inhibition of the pain caused by capsaicin and glutamate, with mean ID(50) values of 11.7 (8.51-16.0) mg/kg and <10 mg/kg, respectively. "
03/01/2003 - "The results showed that the hexane fraction as well as two pure compounds, identified as filicene (1) and filicenal (2), given intraperitoneally, exhibited potent analgesic activity when evaluated in two models of pain in mice, writhing test and formalin-induced pain. "

Related Drugs and Biologics

1.	Triterpenes
2.	Glutamic Acid (Glutamate)
3.	Hexanes
4.	Formaldehyde (Formol)
5.	Capsaicin (Zostrix)
6.	Analgesics (Analgesic Drugs)