HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

(IR,2R)- 2- (4'- (3- phenyl- ureido)- biphenyl- 4- carbonyl)cyclopentanecarboxylic acid

a potent, selective, and orally bioavailable DGAT-1 inhibitor; structure in first source

Also Known As:

A-922500

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - (IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid: 1
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        (IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid: 1
        Phenylurea Compounds: 1
        (IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid: 1

Experts

1.	Cox, Bryan F: 1 article (08/2009)
2.	King, Andrew J: 1 article (08/2009)
3.	Kym, Philip R: 1 article (08/2009)
4.	Larson, Kelly J: 1 article (08/2009)
5.	Mittelstadt, Scott W: 1 article (08/2009)
6.	Reilly, Regina M: 1 article (08/2009)
7.	Segreti, Jason A: 1 article (08/2009)
8.	Souers, Andrew J: 1 article (08/2009)
9.	Zhao, Gang: 1 article (08/2009)

Related Diseases

1.

Hypertriglyceridemia

08/01/2009 - "In addition, high-density lipoprotein-cholesterol was significantly increased (25%) in the Zucker fatty rat by A-922500 administered at 3 mg/kg. This study provides the first report that inhibition of DGAT-1, the final and only committed step of triglyceride synthesis, with a selective small-molecule inhibitor, significantly reduces serum triglyceride levels in both genetic and diet-induced animal models of hypertriglyceridemia. "

Related Drugs and Biologics

1.	Triglycerides (Triacylglycerol)
2.	HDL Cholesterol