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pexacerfont

Also Known As:

BMS-562086

Networked: 7 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - pexacerfont: 7
  - Triazines: 306
    - pexacerfont: 7

Experts

1.	Heilig, Markus: 2 articles (03/2015 - 03/2013)
2.	Augustine-Rauch, Karen: 1 article (01/2021)
3.	Graziano, Michael: 1 article (01/2021)
4.	Liaw, Jiin-Jia: 1 article (01/2021)
5.	Akhondzadeh, Shahin: 1 article (01/2018)
6.	Moazen-Zadeh, Ehsan: 1 article (01/2018)
7.	Morabbi, Mohammad-Javad: 1 article (01/2018)
8.	Razaghi, Emran: 1 article (01/2018)
9.	Safi-Aghdam, Hamideh: 1 article (01/2018)
10.	Vousoghi, Nasim: 1 article (01/2018)

Related Diseases

1.	Anxiety Disorders (Anxiety Disorder) 05/01/2010 - "This study was designed to determine the safety and efficacy of pexacerfont, a selective CRF-1 receptor antagonist, in the treatment of generalized anxiety disorder (GAD). "
2.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/01/2018 - "We assessed the efficacy of pexacerfont, a CRF1 antagonist, for the treatment of withdrawal symptoms. " 01/01/2018 - "Pexacerfont as a CRF1 antagonist for the treatment of withdrawal symptoms in men with heroin/methamphetamine dependence: a randomized, double-blind, placebo-controlled clinical trial."
3.	Alcoholism (Alcohol Abuse) 01/01/2023 - "Subjects were 39 individuals (4 women) with high trait anxiety and moderate to severe alcohol use disorder randomized to receive pexacerfont or placebo. " 03/01/2013 - "Ongoing clinical trials with pexacerfont and verucerfont in moderately to highly severe dependent anxious alcoholics may yield insight as to the role of CRF(1) receptor antagonists in a personalized medicine approach to treat drug or alcohol dependence." 03/13/2015 - "The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study."
4.	Substance-Related Disorders (Drug Abuse) 01/01/2018 - "Also, significant time×treatment interactions were found for all the scales including VAS craving, VAS temptation severity, frequency of temptation, Clinical Opiate Withdrawal Scale, Amphetamine Withdrawal Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory II. Our findings favor pexacerfont as a potential treatment for withdrawal from drug dependence; however, further comprehensive studies are warranted."
5.	Vascular Malformations 01/01/2021 - "T4 supplementation produced a near euthyroid state in pexacerfont-treated dams and completely prevented the fetal vascular malformations. "

Related Drugs and Biologics

1.	CRF receptor type 1
2.	Opiate Alkaloids
3.	Amphetamine (Amfetamine)
4.	Adrenocorticotropic Hormone (ACTH)
5.	Methamphetamine (Desoxyn)
6.	Heroin (Diamorphine)
7.	prucalopride
8.	ramosetron (Nasea)
9.	mosapride

Related Therapies and Procedures

1.	Precision Medicine