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5- (4- hydroxy- 3- trifluoromethylbenzylidene)- 3- (1- methylcyclohexyl)thiazolidine- 2,4- dione

upregulates beta-transducin repeat-containing protein; structure in first source

Also Known As:

OSU CG12; OSU-CG12

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidinediones: 2250
      - 5-(4-hydroxy-3-trifluoromethylbenzylidene)-3-(1-methylcyclohexyl)thiazolidine-2,4-dione: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiazolidinediones: 2250
        5-(4-hydroxy-3-trifluoromethylbenzylidene)-3-(1-methylcyclohexyl)thiazolidine-2,4-dione: 2

Experts

1.	Chen, Ching-Shih: 2 articles (03/2010 - 07/2009)
2.	Kulp, Samuel K: 2 articles (03/2010 - 07/2009)
3.	Wei, Shuo: 2 articles (03/2010 - 07/2009)
4.	Chuang, Hsiao-Ching: 1 article (07/2009)
5.	Ho, Shiuh-Rong: 1 article (07/2009)
6.	Paterson, Andrew J: 1 article (07/2009)
7.	Tsai, Wan-Chi: 1 article (07/2009)
8.	Yang, Hsiao-Ching: 1 article (07/2009)

Related Diseases

1.	Starvation 07/01/2009 - "The ability of OSU-CG12 to mimic glucose starvation to activate beta-TrCP-mediated Sp1 degradation has translational potential to foster novel strategies for cancer therapy." 03/26/2010 - "OSU-CG12, a peroxisome proliferator-activated receptor gamma-inactive ciglitazone derivative, exhibits 1- and 3-order of magnitude higher potency in eliciting starvation-like cellular responses relative to resveratrol and 2-deoxyglucose, respectively." 07/01/2009 - "Based on our finding that thiazolidinediones suppress beta-catenin and cyclin D1 by up-regulating the E3 ligase SCF(beta-TrCP), we hypothesized that beta-transducin repeat-containing protein (beta-TrCP) targets Sp1 for proteasomal degradation in response to glucose starvation or OSU-CG12. "
2.	Neoplasms (Cancer) 07/01/2009 - "The ability of OSU-CG12 to mimic glucose starvation to activate beta-TrCP-mediated Sp1 degradation has translational potential to foster novel strategies for cancer therapy."

Related Drugs and Biologics

1.	beta Catenin
2.	PPAR gamma
3.	Thiazolidinediones
4.	beta-Transducin Repeat-Containing Proteins
5.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
6.	Cyclin D1
7.	Glucose (Dextrose)
8.	Deoxyglucose (2 Deoxy D glucose)
9.	Resveratrol
10.	ciglitazone

Related Therapies and Procedures

1.	Therapeutics