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NP 04634

a protective agent against calcium overload and mitochondrial disruption; structure in first source

Also Known As:

NP-04634; NP04634

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Luna-Medina, Rosario: 1 article (12/2009)
2.	Martinez, Ana: 1 article (12/2009)
3.	Morales-Garcia, Jose A: 1 article (12/2009)
4.	Perez-Castillo, Ana: 1 article (12/2009)
5.	Santos, Angel: 1 article (12/2009)
6.	Cañas, Noelia: 1 article (04/2009)
7.	Egea, Javier: 1 article (04/2009)
8.	García, Antonio G: 1 article (04/2009)
9.	López, Manuela G: 1 article (04/2009)
10.	Martínez, Ana: 1 article (04/2009)

Related Diseases

1.	Stroke (Strokes) 04/01/2009 - "In conclusion, NP04634 is a novel compound of marine origin with cytoprotective properties that might have potential therapeutic implications under pathological circumstances involving Ca(2+) overload and mitochondrial disruption, such as in certain neurodegenerative diseases and/or stroke."
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 04/01/2009 - "In conclusion, NP04634 is a novel compound of marine origin with cytoprotective properties that might have potential therapeutic implications under pathological circumstances involving Ca(2+) overload and mitochondrial disruption, such as in certain neurodegenerative diseases and/or stroke."
3.	Seizures (Absence Seizure) 12/01/2009 - "Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats."
4.	Gliosis 12/01/2009 - "Also, NP04634 prevented the loss of hippocampal CA1 and CA3 pyramidal neurons and reduced the gliosis induced by KA. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Kainic Acid (Kainate)
3.	Calcium
4.	Anticonvulsants (Antiepileptic Drugs)