1- (3,5- bis- trifluoromethylphenyl)- 3- (2,4- dibromo- 6- (1H- tetrazol- 5- yl)phenyl)urea

Membrane Transport Modulator and potassium channel agonist; structure in first source

Also Known As:

NS5806

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - 1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea: 9
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - 1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea: 9

Experts

1.	Antzelevitch, Charles: 4 articles (01/2020 - 03/2009)
2.	Di Diego, José M: 4 articles (01/2020 - 03/2009)
3.	Hu, Dan: 3 articles (01/2020 - 04/2012)
4.	Calloe, Kirstine: 2 articles (11/2014 - 03/2009)
5.	Cordeiro, Jonathan M: 2 articles (11/2014 - 03/2009)
6.	Barajas-Martínez, Hector: 2 articles (07/2013 - 04/2012)
7.	Minoura, Yoshino: 2 articles (07/2013 - 04/2012)
8.	Ackerman, Michael J: 1 article (01/2020)
9.	Barajas-Martinez, Hector: 1 article (01/2020)
10.	Borbáth, Virág: 1 article (01/2020)

Related Diseases

1.	Peripheral Nerve Injuries 01/01/2023 - "NS5806 also reduces the expansion of DRG macrophages and spinal microglia several days after peripheral nerve injury, implying an anti-inflammatory effect. " 11/01/2022 - "NS5806 inhibits ERK activation to attenuate pain induced by peripheral nerve injury." 11/01/2022 - "In this study, we investigated the molecular and cellular mechanisms underlying the analgesic effect of NS5806 in neuropathic pain induced by peripheral nerve injury. "
2.	Neuralgia (Stump Neuralgia) 11/01/2022 - "Since NS5806 and the ERK pathway inhibitors have similar antinociceptive characteristics, this study suggests that NS5806 also acts as an ERK pathway inhibitor to attenuate neuropathic pain." 01/01/2023 - "The compound NS5806 attenuates neuropathic pain via inhibiting extracellular signal-regulated kinase (ERK) activation in neuronal somata located at the dorsal root ganglion (DRG) and superficial spinal dorsal horn. " 11/01/2022 - "In this study, we investigated the molecular and cellular mechanisms underlying the analgesic effect of NS5806 in neuropathic pain induced by peripheral nerve injury. "
3.	Heart Failure 11/01/2014 - "The study investigates how increased Ito, as mediated by the activator NS5806, affects excitation-contraction coupling in chronic heart failure (HF). " 11/01/2014 - "NS5806 partially restores action potential duration but fails to ameliorate calcium transient dysfunction in a computational model of canine heart failure."
4.	Brugada Syndrome 04/01/2023 - "Antiarrhythmic Effect of Artemisinin in an Ex-vivo Model of Brugada Syndrome Induced by NS5806." 01/01/2019 - "Background: NS5806 activates the transient outward potassium current I to, and has been claimed to reproduce Brugada Syndrome (BrS) in ventricular wedge preparations. "
5.	Genetic Predisposition to Disease (Genetic Predisposition) 07/01/2013 - "The Ito agonist NS5806 (10-15 μM) was used to pharmacologically mimic a genetic predisposition to BrS. " 04/01/2012 - "NS5806 (8 μM), a transient outward potassium channel current (I(to) ) agonist, was used to produce an outward shift of current mimicking a genetic predisposition to BrS. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
3.	Sodium Channel Blockers
4.	Potassium Channels (Potassium Channel)
5.	Verapamil (Calan)
6.	Potassium
7.	Carrageenan
8.	Calcium Channel Blockers (Blockers, Calcium Channel)
9.	Calcium
10.	Ajmaline (Wolfina)