3- (3- (1H- benzo(d)imidazol- 2- yl)acryloyl)- 6- chloro- 4- phenylquinolin- 2(1H)- one

01/01/2013 - "Here we extend our earlier studies where we demonstrated that the small molecule BI-69A11 inhibits the growth of melanoma cell lines. "
07/08/2014 - "BI-69A11, a small molecule inhibitor of Akt, efficiently inhibits growth in melanoma cells. "
01/01/2013 - "The ability to attenuate the development of NRAS mutant melanomas supports further development of BI-69A11 for clinical assessment."
01/01/2013 - "Biweekly administration of BI-69A11 starting at 10 weeks or as late as 24 weeks after the induction of mutant Nras expression inhibited melanoma development (100 and 36%, respectively). "
01/01/2013 - "Strikingly, the administration of BI-69A11 inhibited melanoma development in genetically modified mice bearing an inducible form of activated Nras and a deletion of the Ink4a gene (Nras((Q61K)) ::Ink4a(-/-) ). "

01/01/2019 - "This study provides molecular and biochemical insights into the effects of BI-69A11 on EMT in colon carcinoma cells in vitro and in vivo. "
10/15/2015 - "Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma."
05/01/2016 - "BI-69A11 earlier showed potential apoptosis-inducing effect in melanoma and colon carcinoma. "
05/01/2016 - "Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma."
01/01/2019 - "BI-69A11, a competitive Akt inhibitor, displays anti-tumor activity toward melanoma and colon carcinoma. "

01/01/2013 - "BI-69A11 treatment did not inhibit the development of histiocytic sarcomas, which constitute about 50% of the tumors in this model. "
04/01/2009 - "These findings identify BI-69A11 as a potent inhibitor of AKT that is capable of eliciting effective regression of xenograft melanoma tumors."
04/01/2009 - "Significantly, intra-peritoneal injection of BI-69A11 caused effective regression of melanoma tumor xenografts, which coincided with elevated levels of cell death. "
04/01/2009 - "Analysis of BI-69A11 was performed in melanoma cells, a tumor type that commonly exhibits up-regulation of AKT. "
01/01/2019 - "BI-69A11, a competitive Akt inhibitor, displays anti-tumor activity toward melanoma and colon carcinoma. "

10/15/2015 - "In summary; our findings suggest that induction of autophagy lead to the resistance of colon cancer towards BI-69A11 mediated apoptosis."
07/08/2014 - "BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting Akt."
10/15/2015 - "BI-69A11, novel Akt inhibitor, is currently drawing much attention due to its intriguing effect in inducing apoptosis in melanoma, breast, prostate and colon cancer. "

01/01/2013 - "BI-69A11 treatment did not inhibit the development of histiocytic sarcomas, which constitute about 50% of the tumors in this model. "