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cyclo-L-glycyl-L-2-allylproline

a modified diketopiperazine neuroprotectant that improves long-term function after hypoxic-ischaemic brain injury in rats

Also Known As:

NNZ-2591

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - cyclo-L-glycyl-L-2-allylproline: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - cyclo-L-glycyl-L-2-allylproline: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - Diketopiperazines: 59
      - cyclo-L-glycyl-L-2-allylproline: 3

Experts

1.	Guan, J: 2 articles (02/2009 - 11/2007)
2.	Mathai, S: 2 articles (02/2009 - 11/2007)
3.	Zhang, R: 2 articles (02/2009 - 11/2007)
4.	Dale-Gandar, Linden: 1 article (07/2010)
5.	Guan, Jian: 1 article (07/2010)
6.	Hodgkinson, Steve: 1 article (07/2010)
7.	Vickers, Mark H: 1 article (07/2010)
8.	Zhang, Rong: 1 article (07/2010)
9.	Kim, A H: 1 article (02/2009)
10.	Krishnamurthi, R V M: 1 article (02/2009)

Related Diseases

1.	Brain Injuries (Brain Injury) 02/01/2009 - "Cyclo-L-glycyl-L-2-allylproline (NNZ-2591), a modified diketopiperazine, is neuroprotective and improves long-term function after hypoxic-ischaemic brain injury in rats. " 07/11/2010 - "In rats, cyclo-L-glycyl-L-2-allylproline (NNZ-2591), a diketopiperazine, is neuroprotective after ischemic brain injury and also improves motor function in a rat model of Parkinson's disease. " 11/01/2007 - "The current study describes the neuroprotective effects of an endogenous diketopiperazine, cyclo-glycyl-proline (cyclic GP), in rats with hypoxic-ischemic brain injury and the pre-clinical development of an analogue, cyclo-L-glycyl-L-2-allylproline (NNZ 2591), modified for improved bioavailability. "
2.	Parkinson Disease (Parkinson's Disease) 02/01/2009 - "The present studies were designed to examine both the neuroprotective and neurotrophic actions of NNZ-2591 on neurochemical and behavioural changes in a rat model of Parkinson's disease. " 07/11/2010 - "In rats, cyclo-L-glycyl-L-2-allylproline (NNZ-2591), a diketopiperazine, is neuroprotective after ischemic brain injury and also improves motor function in a rat model of Parkinson's disease. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 02/01/2009 - "NNZ-2591 has potential as a therapeutic agent for neurodegenerative disorders."
4.	Amnesia (Dissociative Amnesia) 07/11/2010 - "Given nootropic actions of diketopiperazines, we investigated the effects of and potential role for acetylcholine neurotransmission in NNZ-2591 on spatial memory after scopolamine-induced amnesia in rats. "

Related Drugs and Biologics

1.	Diketopiperazines
2.	Neuroprotective Agents
3.	Proline (L-Proline)
4.	Nootropic Agents (Nootropics)
5.	Scopolamine (Hyoscine)
6.	Acetylcholine (Acetylcholine Chloride)