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WAY-362450

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a synthetic farnesoid X receptor (FXR) agonist that promotes cholesterol lowering in models of dyslipidemia; structure in first source

Also Known As:

FXR-450; XL335

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azepines: 7
    - WAY-362450: 5
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - WAY-362450: 5

Experts

1.	Harnish, Douglas C: 3 articles (08/2009 - 02/2009)
2.	Wang, Juan: 2 articles (08/2009 - 02/2009)
3.	Zhang, Songwen: 2 articles (08/2009 - 02/2009)
4.	Liu, Qiangyuan: 2 articles (08/2009 - 02/2009)
5.	Evans, Mark J: 2 articles (06/2009 - 03/2009)
6.	Krueger, Julie A: 2 articles (06/2009 - 03/2009)
7.	Gardell, Stephen J: 2 articles (06/2009 - 03/2009)
8.	Wang, Shuguang: 2 articles (06/2009 - 03/2009)
9.	Peng, Xiaomin: 1 article (01/2014)
10.	Wu, Weibin: 1 article (01/2014)

Related Diseases

1.	Dyslipidemias (Dyslipidemia) 03/01/2009 - "These studies demonstrate a consistent ability of WAY-362450 to lower both serum TG and cholesterol levels and suggest that synthetic FXR agonists may have clinical utility in the treatment of mixed dyslipidemia."
2.	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/03/2014 - "We used a specific agonist of FXR WAY-362450 to study the effect of pharmacological activation of FXR in alcoholic liver disease. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/06/2009 - "In this study, we report that two synthetic FXR agonists, WAY-362450 and GW4064, suppressed interleukin-6-induced CRP expression in human Hep3B hepatoma cells. "
4.	Hypertriglyceridemia 06/01/2009 - "WAY-362450 inhibition of hypertriglyceridemia remained intact in LDLR(-/-) or apoE(-/-) mice lacking SHP of both sexes. "
5.	Inflammation 08/01/2009 - "Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis."

Related Drugs and Biologics

1.	Cholesterol
2.	GW 4064
3.	Methionine (L-Methionine)
4.	Choline (Choline Chloride)
5.	Apolipoproteins E (ApoE)