CD59 Antigens

Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)

Also Known As:

CD59 Antigen; Membrane Inhibitor of Reactive Lysis; Antigens, CD59; HRF20; Homologous Restriction Factor 20; MACIF; Membrane Attack Complex Inhibition Factor; Protectin

Pharmalogical Action Categories:

Complement Inactivating Agents

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - GPI-Linked Proteins: 140
        CD59 Antigens: 109
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - GPI-Linked Proteins: 140
        CD59 Antigens: 109
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - GPI-Linked Proteins: 140
        CD59 Antigens: 109
    - Lipid-Linked Proteins: 1
      - GPI-Linked Proteins: 140
        CD59 Antigens: 109

mouse CD59b protein

Bio-Agent Context: Research Results