HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3- (2,4- diamino- 6- (3- hydroxyphenyl)pteridin- 7- yl)phenol

an NSAID that inhibits PI-3K gamma and delta

Also Known As:

TG100-115

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol: 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - 3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol: 5

Experts

1.	Dneprovskaia, Elena: 2 articles (03/2009 - 12/2006)
2.	Doukas, John: 2 articles (03/2009 - 12/2006)
3.	Noronha, Glenn: 2 articles (03/2009 - 12/2006)
4.	Soll, Richard: 2 articles (03/2009 - 12/2006)
5.	Wrasidlo, Wolfgang: 2 articles (03/2009 - 12/2006)
6.	Li, Guofei: 1 article (12/2019)
7.	Zhao, Limei: 1 article (12/2019)
8.	Bae, Yeonju: 1 article (04/2017)
9.	Hur, Wooyoung: 1 article (04/2017)
10.	Jun, JinJoo: 1 article (04/2017)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 03/01/2009 - "In conclusion, aerosolized TG100-115 displays pharmacokinetic, safety, and biological activity profiles favorable for further development as a therapy for both asthma and COPD. " 03/01/2009 - "Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease." 03/01/2009 - "For this reason, in a series of preclinical studies, we tested the potential of a recently developed small-molecule inhibitor of these two isoforms, TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol], as a form of anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). "
2.	Respiratory Tract Diseases (Respiratory Tract Disease) 03/01/2009 - "For this reason, in a series of preclinical studies, we tested the potential of a recently developed small-molecule inhibitor of these two isoforms, TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol], as a form of anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). "
3.	Myocardial Infarction 04/01/2007 - "In the present paper, we review the preclinical development of TG100-115, a PI3K (phosphoinositide 3-kinase) gamma/delta isoform-specific inhibitor currently in clinical trials for the reduction of acute MI (myocardial infarction). "
4.	Asthma (Bronchial Asthma) 03/01/2009 - "In conclusion, aerosolized TG100-115 displays pharmacokinetic, safety, and biological activity profiles favorable for further development as a therapy for both asthma and COPD. " 03/01/2009 - "In a murine asthma model, aerosolized TG100-115 markedly reduced the pulmonary eosinophilia and the concomitant interleukin-13 and mucin accumulation characteristic of this disease. " 03/01/2009 - "Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease." 03/01/2009 - "For this reason, in a series of preclinical studies, we tested the potential of a recently developed small-molecule inhibitor of these two isoforms, TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol], as a form of anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). "
5.	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 03/01/2009 - "In a murine asthma model, aerosolized TG100-115 markedly reduced the pulmonary eosinophilia and the concomitant interleukin-13 and mucin accumulation characteristic of this disease. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Phenol (Carbolic Acid)
3.	Nonmuscle Myosin Type IIA
4.	Interleukin-13
5.	Steroids
6.	Smoke
7.	Phosphotransferases (Kinase)
8.	Phosphatidylinositols (Phosphatidylinositol)
9.	Mucins
10.	Micelles

Related Therapies and Procedures

1.	Therapeutics