anticentromere antibody

antibody to centromere (kinetochore) that reacts with centromeric regions of chromosomes derived from humans, mice, and Chinese hamsters; present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma

Also Known As:

Networked: 90 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ishikawa, Osamu: 2 articles (12/2014 - 11/2009)
2.	Fritzler, Marvin: 2 articles (04/2012 - 03/2007)
3.	Baron, Murray: 2 articles (04/2012 - 03/2012)
4.	Medsger, Thomas A: 2 articles (03/2012 - 01/2003)
5.	Pope, Janet E: 2 articles (03/2012 - 11/2002)
6.	Kurokochi, Kazutaka: 2 articles (08/2010 - 02/2009)
7.	Senda, Shoichi: 2 articles (08/2010 - 02/2009)
8.	Yoneyama, Hirohito: 2 articles (08/2010 - 02/2009)
9.	Haba, Reiji: 2 articles (08/2010 - 02/2009)
10.	Nishioka, Mikio: 2 articles (08/2010 - 02/2009)

Related Diseases

1.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 12/01/1982 - "The pathogenetic significance of anticentromere antibody is not yet established, but this study confirms its specificity for scleroderma in the context of primary biliary cirrhosis." 07/01/1985 - "The anticentromere antibody was found in 10% of cases of primary biliary cirrhosis and occasionally in other conditions; the antibody staining multiple nuclear dots was strictly confined to primary biliary cirrhosis (17%). " 12/01/1982 - "Anticentromere antibody in primary biliary cirrhosis." 08/01/2010 - "Recent studies have revealed that primary biliary cirrhosis patients with anticentromere antibody (ACA) commonly develop portal hypertension. " 10/01/1994 - "[Two patients with positive anticentromere antibody showing different clinical features of CREST syndrome or primary biliary cirrhosis (PBC)]."
2.	Systemic Scleroderma (Systemic Sclerosis) 01/01/2006 - "Scleroderma renal crisis in a patient with anticentromere antibody-positive limited cutaneous systemic sclerosis." 01/01/2003 - "To compare anti-Th/To-positive and anticentromere antibody (ACA)-positive patients with limited cutaneous systemic sclerosis (lcSSc). " 01/01/2003 - "A comparison between anti-Th/To- and anticentromere antibody-positive systemic sclerosis patients with limited cutaneous involvement." 10/01/2001 - "Ankle brachial pressure index in systemic sclerosis: influence of disease subtype and anticentromere antibody." 12/01/1995 - "HLA class II genes associated with anticentromere antibody in Japanese patients with systemic sclerosis (scleroderma)."
3.	Interstitial Lung Diseases (Interstitial Lung Disease) 01/01/2004 - "The frequencies of interstitial lung disease and renal crisis were significantly higher in group 1 than in group 2. The frequencies of anti-topoisomerase I antibody (anti-topo I) and anti-SS-A antibody were significantly higher in group 1 than in group 2. Conversely, the frequency of anticentromere antibody was significantly higher in group 2 than in group 1. This study demonstrates the clinical significance of a new subset of SSc (defined as RPSSc), which is characterized by a markedly rapid progression of skin thickening. " 03/01/2012 - "Compared to mimickers, patients with SSc were more likely to have skin thickening (OR 427); telangiectasias (OR 91); anti-RNA polymerase III antibody (OR 75); puffy fingers (OR 35); finger flexion contractures (OR 29); tendon/bursal friction rubs (OR 27); anti-topoisomerase I antibody (OR 25); RP (OR 24); fingertip ulcers/pitting scars (OR 19); anticentromere antibody (OR 14); abnormal nailfold capillaries (OR 10); gastroesophageal reflux disease symptoms (OR 8); antinuclear antibody, calcinosis, dysphagia, and esophageal dilation (all OR 6); interstitial lung disease/pulmonary fibrosis (OR 5); and anti-PM-Scl antibody (OR 2). "
4.	Portal Hypertension 08/01/2010 - "Recent studies have revealed that primary biliary cirrhosis patients with anticentromere antibody (ACA) commonly develop portal hypertension. " 04/01/2014 - "Because patients with anticentromere antibody positive PBC-SSc are at a high risk of developing portal hypertension, particular attention should be paid to the management of gastroesophageal varices. "
5.	CREST Syndrome (Syndrome, CREST) 04/01/1989 - "She had a high titer of anticentromere antibody in her serum without any symptoms of CREST syndrome. " 07/01/1982 - "Anticentromere antibody, a test of high specificity for the CREST syndrome, was present in the serum. " 10/01/1980 - "A case report illustrating the appearance of the anticentromere antibody at a time when Raynaud's phenomenon antedated the clinical diagnosis of CREST syndrome is presented." 10/01/1994 - "[Two patients with positive anticentromere antibody showing different clinical features of CREST syndrome or primary biliary cirrhosis (PBC)]." 09/01/1989 - "Anticentromere antibody positive CREST syndrome associated with polyarthritis, renal impairment and mixed cryoglobulinaemia."

Related Drugs and Biologics

1.	Type I DNA Topoisomerases (Topoisomerase I)
2.	trioctyl phosphine oxide (TOPO)
3.	Proteins (Proteins, Gene)
4.	centromere protein A
5.	Antinuclear Antibodies
6.	Antibodies
7.	Autoantibodies
8.	Endothelins (Endothelin)
9.	Biological Markers (Surrogate Marker)
10.	Silver Sulfadiazine (SSD)

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Amputation