anticentromere antibody

antibody to centromere (kinetochore) that reacts with centromeric regions of chromosomes derived from humans, mice, and Chinese hamsters; present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma

Also Known As:

Networked: 214 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishibashi, Hiromi: 4 articles (10/2011 - 01/2007)
2.	Komori, Atsumasa: 4 articles (10/2011 - 01/2007)
3.	Nakamura, Minoru: 4 articles (10/2011 - 01/2007)
4.	Asano, Yoshihide: 3 articles (08/2020 - 04/2005)
5.	Sato, Shinichi: 3 articles (08/2020 - 08/2004)
6.	Mayes, Maureen D: 3 articles (01/2014 - 12/2006)
7.	Allanore, Y: 3 articles (07/2012 - 03/2005)
8.	Baron, Murray: 3 articles (04/2012 - 10/2011)
9.	Mahler, Michael: 3 articles (04/2012 - 01/2010)
10.	Fritzler, Marvin J: 3 articles (10/2011 - 09/2007)

Related Diseases

1.	Systemic Scleroderma (Systemic Sclerosis) 01/01/2021 - "The goals of this study were to evaluate whether (1) anticentromere antibody (ACA)- and antitopoisomerase antibody (ATA)-specific isotype expression, and (2) organ involvement are associated with the degree of microangiopathy in systemic sclerosis (SSc). " 05/01/1994 - "Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study." 12/01/2021 - "Anticentromere Antibody Levels and Isotypes and the Development of Systemic Sclerosis." 01/01/2017 - "Anticentromere antibody (ACA) is generally considered to be a serological marker for systemic sclerosis (SSc). " 07/01/2013 - "This is the first reported case of systemic sclerosis with anti-Ku and anti-centromere antibodies."
2.	Connective Tissue Diseases (Connective Tissue Disease) 11/01/1987 - "Fifty-eight patients with Raynaud's syndrome who had no evidence of definite underlying connective tissue disease had serum analyzed for the presence of anticentromere antibody using indirect immunofluorescence techniques on HEp-2 cell lines. " 09/01/1985 - "Anticentromere antibody is not specific for connective tissue disease with a promising prognosis." 10/01/1994 - "Anti-chromo and anti-centromere antibodies (ACA) were measured by immunoblotting in 50 patients with systemic sclerosis (SSc) and 58 connective tissue disease controls. " 09/01/1989 - "Anticentromere antibody in patients without CREST and scleroderma: association with active digital vasculitis, rheumatic and connective tissue disease." 11/01/1987 - "The clinical findings in the anticentromere antibody-positive group are suggestive of a transition to a connective tissue disease with features of the CREST syndrome."
3.	Skin Ulcer 10/01/2014 - " to older Italian SSc series, the present patients' population showed a significantly increased prevalence of limited cutaneous SSc (from 72 to 87.5%; p ≤.0001) and serum anti-centromere antibodies (from 39 to 47,4%; p ≤.001), with a significant reduction of lung (from 81 to 63.7%; p ≤.0001), heart (from 35 to 20.5%; p ≤.0001), and renal involvement (from 10 to 3.8%; p ≤.0001), and skin ulcers (from 54 to 16.5%; p ≤.0001). "
4.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 12/01/1982 - "The pathogenetic significance of anticentromere antibody is not yet established, but this study confirms its specificity for scleroderma in the context of primary biliary cirrhosis." 12/01/2013 - "Diagnostic and clinical significance of anti-centromere antibodies in primary biliary cirrhosis." 10/01/2011 - "Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis (PBC). " 05/01/2010 - "Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis (PBC). " 01/01/2007 - "Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis."
5.	Interstitial Lung Diseases (Interstitial Lung Disease) 12/01/2018 - "Raynaud's phenomena, finger skin thickening, interstitial lung disease, and positive anticentromere antibody findings indicated systemic sclerosis (SSc). " 07/04/2010 - "Anti-centromere antibodies were associated with limited cutaneous SSc and anti-Scl-70 antibodies with diffuse cutaneous SSc and interstitial lung disease. " 01/01/2008 - "Anti-centromere antibodies are associated with limited cutaneous involvement and risk for pulmonary hypertension, whereas anti-topoisomerase I is associated with diffuse progressive disease and severe interstitial lung disease. " 01/01/2004 - "The frequencies of interstitial lung disease and renal crisis were significantly higher in group 1 than in group 2. The frequencies of anti-topoisomerase I antibody (anti-topo I) and anti-SS-A antibody were significantly higher in group 1 than in group 2. Conversely, the frequency of anticentromere antibody was significantly higher in group 2 than in group 1. This study demonstrates the clinical significance of a new subset of SSc (defined as RPSSc), which is characterized by a markedly rapid progression of skin thickening. " 01/01/2021 - "Vitiligo, Raynaud's phenomenon and anti-centromere antibodies were preceded while eosinophilia, interstitial lung disease, rash, thickening of the skin and asymptomatic cryoglobulinemia were diagnosed concomitantly with the neoplasm. "

Related Drugs and Biologics

1.	anti-scl-70 autoantibodies
2.	Antibodies
3.	Antinuclear Antibodies
4.	trioctyl phosphine oxide (TOPO)
5.	Anti-Idiotypic Antibodies
6.	Proliferating Cell Nuclear Antigen (PCNA)
7.	Cytokines
8.	Steroids
9.	Salts
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Prostheses and Implants (Prosthesis)
3.	Therapeutics
4.	Debridement
5.	Surgical Amputation (Amputations)