Attenuated familial adenomatous polyposis

Also Known As:

Familial Adenomatous Polyposis, Attenuated

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
Digestive System Diseases: 1042
- Gastrointestinal Diseases: 5874
  - Gastrointestinal Neoplasms: 4373
    - Intestinal Neoplasms: 523
      - Colorectal Neoplasms: 73999
        Adenomatous Polyposis Coli: 3446
        Attenuated familial adenomatous polyposis: 11
  - Intestinal Diseases: 1601
- Digestive System Neoplasms: 236
  - Gastrointestinal Neoplasms: 4373
    - Intestinal Neoplasms: 523
      - Colorectal Neoplasms: 73999
        Adenomatous Polyposis Coli: 3446
        Attenuated familial adenomatous polyposis: 11
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Hereditary Neoplastic Syndromes: 112
    - Adenomatous Polyposis Coli: 3446
      - Attenuated familial adenomatous polyposis: 11

Related Diseases

1.	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
2.	Peutz-Jeghers Syndrome (Polyposis, Hamartomatous Intestinal)
3.	Multiple Hamartoma Syndrome (Cowden's Disease)
4.	Adenoma (Adenomas)
5.	Adenocarcinoma

Experts

1.	Anele, Chukwuemeka C: 1 article (04/2022)
2.	Chauhan, Jeshu: 1 article (04/2022)
3.	Clark, Susan K: 1 article (04/2022)
4.	Faiz, Omar D: 1 article (04/2022)
5.	Latchford, Andrew R: 1 article (04/2022)
6.	Martin, Isabel: 1 article (04/2022)
7.	McGinty Duggan, Patricia M: 1 article (04/2022)
8.	Dawson, H: 1 article (05/2017)
9.	Hartmann, A: 1 article (05/2017)
10.	Rau, T T: 1 article (05/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Attenuated familial adenomatous polyposis:

1.	N- (3- phenyl- n- propyl)- 1- phenyl- 2- aminopropane (PPAP)IBA 01/01/2017 - "Adenomatous polyposis syndromes can be divided into; familial adenomatous polyposis (FAP) - classic FAP and attenuated familial adenomatous polyposis (AFAP), MUTYH-associated polyposis (MAP), NTHL1-associated polyposis (NAP) and polymerase proofreading-associated polyposis (PPAP). " 05/01/2017 - "The resulting differential diagnosis includes (attenuated) familial adenomatous polyposis ([a]FAP), MUTYH-associated polyposis (MAP), polymerase proofreading-associated polyposis (PPAP), phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS), Peutz-Jeghers syndrome and juvenile polyposis, each with a specific genetic background."
2.	RNA IsoformsIBA 03/01/2007 - "Constitutional high expression of an APC mRNA isoform in a subset of attenuated familial adenomatous polyposis patients."
3.	RNA Splice SitesIBA 09/01/2010 - "A distinct mutation on the alternative splice site of APC exon 9 results in attenuated familial adenomatous polyposis phenotype."
4.	Protein Isoforms (Isoforms)IBA 01/01/2003 - "A predominant increase in the APC gene isoform with exon 9a in a case of attenuated familial adenomatous polyposis."
5.	Sulindac (Copal)FDA LinkGeneric 10/01/2002 - "Our case suggests that treatment with sulindac accompanied by intensive colonoscopic surveillance may be a choice of management for attenuated familial adenomatous polyposis." 10/01/2002 - "We report a patient with attenuated familial adenomatous polyposis who has been treated with sulindac for five years. " 10/01/2002 - "Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case."
6.	Phosphoric Monoester Hydrolases (Phosphatases)IBA 05/01/2017 - "The resulting differential diagnosis includes (attenuated) familial adenomatous polyposis ([a]FAP), MUTYH-associated polyposis (MAP), polymerase proofreading-associated polyposis (PPAP), phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS), Peutz-Jeghers syndrome and juvenile polyposis, each with a specific genetic background."
7.	Indicators and Reagents (Reagents)IBA 04/01/2022 - "Diagnosis of attenuated familial adenomatous polyposis should be based on phenotype; genotype is not a reliable indicator. "
8.	Codon (Codons)IBA 10/01/2002 - "Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case."
9.	TensinsIBA 05/01/2017 - "The resulting differential diagnosis includes (attenuated) familial adenomatous polyposis ([a]FAP), MUTYH-associated polyposis (MAP), polymerase proofreading-associated polyposis (PPAP), phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS), Peutz-Jeghers syndrome and juvenile polyposis, each with a specific genetic background."

Therapies and Procedures

1.	Gastrectomy 07/20/2008 - "Total gastrectomy for gastric dysplasia in a patient with attenuated familial adenomatous polyposis syndrome." 03/01/2011 - "Total gastrectomy and pancreaticoduodenectomy for gastric polyposis and duodenal ampullary adenoma in a patient with attenuated familial adenomatous polyposis."
2.	Adjuvant Chemotherapy 06/07/2005 - "A 22 year-old male with attenuated familial adenomatous polyposis received neo-adjuvant chemotherapy and radiation prior to surgery for rectal adenocarcinoma. "
3.	Restorative Proctocolectomy 08/01/2015 - "Prophylactic proctocolectomy with an ileoanal neo-reservoir is the established procedure in non-attenuated familial adenomatous polyposis (FAP). "
4.	Pancreaticoduodenectomy 03/01/2011 - "Total gastrectomy and pancreaticoduodenectomy for gastric polyposis and duodenal ampullary adenoma in a patient with attenuated familial adenomatous polyposis."
5.	Therapeutics 06/07/2005 - "Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis."