autosomal dominant nonsyndromic sensorineural 22 Deafness

Also Known As:

Deafness, autosomal dominant nonsyndromic sensorineural 22; DFNA 22; DFNA22; Deafness, Autosomal Dominant 22

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Autosomal Recessive 37 Deafness
2.	Hearing Loss (Hearing Impairment)
3.	Sensorineural Hearing Loss
4.	Deafness (Deaf Mutism)
5.	Nonsyndromic Deafness

Experts

1.	Arden, Susan D: 1 article (10/2016)
2.	Buss, Folma: 1 article (10/2016)
3.	Butt, Tariq: 1 article (10/2016)
4.	Kendrick-Jones, John: 1 article (10/2016)
5.	Tumbarello, David A: 1 article (10/2016)
6.	Beutner, Dirk: 1 article (01/2013)
7.	Borck, Guntram: 1 article (01/2013)
8.	Kubisch, Christian: 1 article (01/2013)
9.	Lang-Roth, Ruth: 1 article (01/2013)
10.	Nuernberg, Gudrun: 1 article (01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to autosomal dominant nonsyndromic sensorineural 22 Deafness:

1.	Myosins (Myosin)IBA 04/15/2008 - "Seven different unconventional myosin genes are involved in ten different types of syndromic and nonsyndromic hearing loss with different patterns of inheritance: MYO7A in DFNA11/DFNB2/USH1B, MYH9 in DFNA17, MYH14 in DFNA4, MYO6 in DFNA22/DFNB37, MYO3A in DFNB30, MYO1A in DFNA48, and MYO15A in DFNB3. " 01/01/2013 - "Mutations in MYO6 encoding an atypical myosin motor protein important for inner ear hair cell function have been associated with autosomal recessive (DFNB37) and autosomal dominant (DFNA22) types of hearing loss in a few families worldwide. "
2.	myosin VIIBA 05/01/2003 - "These mutations, along with a previously published missense allele linked to autosomal dominant progressive hearing loss (DFNA22), provide an allelic spectrum that probes the relationship between myosin VI dysfunction and the resulting phenotype." 10/01/2016 - "Mutations in myosin VI have been associated with autosomal-recessive (DFNB37) and autosomal-dominant (DFNA22) deafness in humans. "
3.	Nonsense Codon (Nonsense Mutation)IBA 04/15/2008 - "A novel nonsense mutation in MYO6 is associated with progressive nonsyndromic hearing loss in a Danish DFNA22 family."
4.	Proteins (Proteins, Gene)FDA Link 01/01/2013 - "Mutations in MYO6 encoding an atypical myosin motor protein important for inner ear hair cell function have been associated with autosomal recessive (DFNB37) and autosomal dominant (DFNA22) types of hearing loss in a few families worldwide. "
5.	DNA (Deoxyribonucleic Acid)IBA 05/01/2008 - "As MYO6 has previously been reported as responsible for the hearing loss at loci DFNA22 and DFNB37, respectively, DNA sequencing of the coding region and the promoter of MYO6 was performed but this analysis did not reveal any mutations. "

Therapies and Procedures

1.	Cochlear Implantation 01/01/2013 - "A novel MYO6 splice site mutation causes autosomal dominant sensorineural hearing loss type DFNA22 with a favourable outcome after cochlear implantation."