Acquired agranulocytosis

A form of agranulocytosis that is caused by certain drugs, especially ANTINEOPLASTIC AGENTS and ANTIPSYCHOTIC AGENTS.

Also Known As:

Agranulocytic Angina; Granulocytopenia, Primary; Neutropenia, Malignant

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Cytopenia: 2582
    - Leukopenia: 5826
      - Agranulocytosis: 4051
        Acquired agranulocytosis: 14
  - Leukocyte Disorders: 8
    - Leukopenia: 5826
      - Agranulocytosis: 4051
        Acquired agranulocytosis: 14

Related Diseases

1.	Sepsis (Septicemia)
2.	Purpura
3.	Multiple Trauma (Multiple Injuries)
4.	Eosinophilia
5.	Aplastic Anemia (Anemia, Hypoplastic)

Experts

1.	Haak, Eric A F: 1 article (01/2014)
2.	Leeksma, Onno C: 1 article (01/2014)
3.	Vos, Nicola S: 1 article (01/2014)
4.	Gonçalves, André L C: 1 article (05/2005)
5.	Neto, Firmino R S: 1 article (05/2005)
6.	Ushirohira, Jorge: 1 article (05/2005)
7.	Zambrana, Fernanda F T: 1 article (05/2005)
8.	Zambrana, Fábio F T: 1 article (05/2005)
9.	Zambrana, Jorge T: 1 article (05/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acquired agranulocytosis:

1.	Pyridoxine (Pyridoxin)FDA LinkGeneric 12/01/1946 - "Agranulocytic angina treated with pyridoxine hydrochloride." 04/01/1945 - "Agranulocytic Angina Effectively Treated with Intravenous Pyridoxine (Vitamin B(6))."
2.	Vitamin B 6IBA 04/01/1945 - "Agranulocytic Angina Effectively Treated with Intravenous Pyridoxine (Vitamin B(6))."
3.	sargramostim (Leukine)FDA Link 10/01/1992 - "Rapid neutrophil recovery from acquired agranulocytosis by recombinant human granulocyte-macrophage colony-stimulating factor in an intensive care patient." 10/01/1993 - "Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was given to an intensive-care patient with polytrauma in a life-threatening situation with acquired agranulocytosis and sepsis. "
4.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/01/1993 - "Instant therapy of acquired agranulocytosis and sepsis by recombinant granulocyte-macrophage colony-stimulating factor in a polytrauma patient."
5.	Penicillins (Penicillin)FDA Link 01/11/1947 - "Penicillin in agranulocytic angina; report of a case."
6.	MethylthiouracilIBA 03/10/1947 - "Agranulocytic angina from methylthiouracil; Healing."
7.	Levamisole (Decaris)FDA Link 01/01/2014 - "This patient had acquired agranulocytosis, due to the use of cocaine adulterated with levamisole."
8.	Dipyrone (Metamizole)IBA 12/01/1998 - "The estimated excess mortality due to community-acquired agranulocytosis, aplastic anemia, anaphylaxis, and serious upper gastrointestinal complications was 185 per 100 million for aspirin, 592 per 100 million for diclofenac, 20 per 100 million for acetaminophen, and 25 per 100 million for dipyrone. "
9.	Diclofenac (SR 38)FDA LinkGeneric 12/01/1998 - "The estimated excess mortality due to community-acquired agranulocytosis, aplastic anemia, anaphylaxis, and serious upper gastrointestinal complications was 185 per 100 million for aspirin, 592 per 100 million for diclofenac, 20 per 100 million for acetaminophen, and 25 per 100 million for dipyrone. "
10.	Cocaine (Cocaine HCl)IBA 01/01/2014 - "This patient had acquired agranulocytosis, due to the use of cocaine adulterated with levamisole."

Therapies and Procedures

1.	Therapeutics 03/01/1945 - "A Case of Tropical Eosinophilia Developing Agranulocytic Angina during Arsenical Therapy." 03/01/1945 - "A FATAL CASE OF PURPURA HAEMORRHAGICA WITH AGRANULOCYTIC ANGINA AFTER ARSPHENAMINE THERAPY." 10/01/1993 - "Instant therapy of acquired agranulocytosis and sepsis by recombinant granulocyte-macrophage colony-stimulating factor in a polytrauma patient."
2.	Critical Care (Surgical Intensive Care) 10/01/1992 - "Rapid neutrophil recovery from acquired agranulocytosis by recombinant human granulocyte-macrophage colony-stimulating factor in an intensive care patient." 10/01/1993 - "Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was given to an intensive-care patient with polytrauma in a life-threatening situation with acquired agranulocytosis and sepsis. "