A clinically and genetically heterogeneous developmental condition where visceral organs (heart, lungs, liver, spleen, and stomach) are oriented randomly with respect to each other and the left-right axis. CONGENITAL HEART DEFECTS and ARRYTHMIAS are common in affected individuals. The X-linked form is caused by mutations in the ZIC3 gene (OMIM: 306955). The autosomal 5 form is dominant and is caused by mutations in the NODAL gene. OMIM: 270100
Also Known As:
Heterotaxy, visceral, X-linked; Dextrocardia with other cardiac malformations; Heterotaxy, Visceral, 1, X-Linked; Heterotaxy, Visceral, 5, Autosomal; Laterality, X-linked; Situs inversus, complex cardiac defects, and splenic defects, X-linked; Visceral heterotaxia