trisomy Chromosome 16

01/01/2012 - "A wide variety of evidence from studies on DS individuals and mouse models of DS indicates that synaptic plasticity is adversely affected in human trisomy 21 and mouse segmental trisomy 16, respectively, an outcome that almost certainly extensively contributes to the cognitive impairments associated with DS. "
08/16/2007 - "The CNh and CTb cell lines are derived from the cerebral cortex of normal and trisomy 16 mice, an animal model of human trisomy 21, Down syndrome (DS), and represent in vitro models to study cellular events associated with the human condition. "
09/01/2006 - "To explain these alterations, important results are obtained from studies about murine trisomy 16 (animal model of Down's syndrome). "
12/01/1997 - "The trisomy 16 mouse is a widely accepted animal model for the study of the embryonic development of human trisomy 21. "
10/01/1996 - "In the present study, segmental trisomy 16 (Ts65Dn) mice, an animal model of Down Syndrome (DS), were examined for sensorimotor, reproductive, and aggression abnormalities associated with DS. "

10/01/1990 - "Therefore, CVS can be nearly 100% accurate when both direct studies and cultures are examined in cases of mosaicism and other cell lines of possible non-fetal origin, such as trisomy 16, trisomy 18, translocation (21;21), and 45,X cells."
01/01/1984 - "The increase in trisomy was largely attributable to trisomy 16, which showed a two-fold increase over the duration of the study. "
07/01/2004 - "Of the rare trisomies presented, three were mosaic trisomy 16 (two of which were CPM), and the remainder comprised single cases of mosaic trisomies of 8, 9, 10, 11, 12, 14, 5 and 15--the last two being CPM. "
03/01/2003 - "The levels of trisomy in different fetal-placental tissues are significant predictors of some measures of outcome in mosaic trisomy 16 pregnancies."
03/01/1997 - "The frequency of trisomies, with the exception trisomy 16, was related with advanced maternal age."

01/01/2008 - "Murine trisomy 16 (Ts16) is a useful model to study the deleterious effect of aneuploidy in neural pathophysiology. "
09/01/1998 - "It is likely that trisomy 16 cells are sometimes present in the early developing embryo even though subsequent cytogenetic studies on fetal or neonatal tissues may not detect any aneuploid cells. "
05/01/2013 - "The extraembryonic mesoderm of embryos with trisomy 16 appeared to be less methylated compared to the diploid tissue, whereas the cytotrophoblast of aneuploid embryos was hypermethylated. "
01/01/2005 - "To investigate the genetic contribution to phenotypic variability in aneuploidy, we generated mice with trisomy 16 (Ts16) by mating [Rb(6.16)24Lub x Rb(16.17)7Bnr]F1 males with females from four inbred strains, BALB/cJ, C3H/HeJ, C57BL/6J, and DBA/2J. "
09/01/1998 - "Following the prenatal detection of trisomy 16 cells, aneuploid cells are almost never found in fetal or neonatal lymphocytes. "

02/01/2001 - "Trisomy 16 mice could serve as an animal model for Hirschsprung's disease for aganglionic bowel in the distal part of colon. "
02/01/2001 - "The development of colon innervation in trisomy 16 mice and Hirschsprung's disease."
06/01/1999 - "Trisomy 16 mice occur with congenital megacolon, and trisomy 16 mice may be also regard as an animal model for Hirschsprung's disease."
02/01/2001 - "To study the colon innervation of trisomy 16 mouse, an animal model for Down's syndrome, and the expression of protein gene product 9.5 (PGP 9.5) in the stenosed segment of colon in Hirschsprung's disease (HD). "
06/01/1999 - "To study the developmental defect of the enteric nervous system in trisomy 16 mice, an animal model for Down syndrome, and reveal the possibility of trisomy 16 mice with congenital megacolon. "

05/01/2001 - "Numbers of activated versus non-activated T lymphocytes, NK cells and macrophages were compared in decidua from women with: (i) unexplained RSA who had a normal male karyotype (n = 17) miscarriage; (ii) unexplained RSA who had a trisomy 16 (n = 21) miscarriage; and (iii) normal gestationally age-matched first trimester pregnancies following elective termination procedures (n = 20). "
05/01/2001 - "We differentiated specifically between normal karyotyped male fetuses and abnormal karyotyped fetuses with trisomy 16 because trisomy 16 is not compatible with life and is thus a non-controversial cause of spontaneous miscarriage. "
12/01/1998 - "Trisomy 16 is the most frequent autosomal anomaly seen in early spontaneous abortions, accounting for 15 per cent of all chromosomally abnormal early spontaneous abortions. "
10/01/1995 - "In the present report, we summarize our observations on 62 spontaneous abortions with trisomy 16. "
12/01/2012 - "Trisomy in pregnancy increases risks of miscarriage, fetal anomalies, and perinatal complications, with trisomy 16 the most common trisomy in human conceptions. "