Calcifying Epithelial Odontogenic Tumor

A rare slow growing, locally invasive odontogenic tumor. It most often grows intraosseously in the mandible and less frequently in the maxilla, and gingiva. It is characterized by the presence of a fibrous stroma, epithelial cells with abundant eosinophilic cytoplasm, and AMYLOID material which is often calcified.

Also Known As:

Networked: 41 relevant articles (0 outcomes, 7 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Odontogenic Tumors (Dental Tissue Neoplasm)
2.	Ameloblastoma
3.	Fibroma (Fibromatosis)
4.	Adenoameloblastoma
5.	Odontoma

Experts

1.	Chiang, Chun-Pin: 2 articles (07/2021 - 01/2021)
2.	Crivelini, Marcelo Macedo: 2 articles (05/2016 - 03/2012)
3.	de Sousa, Suzana Cantanhede Orsini Machado: 2 articles (05/2016 - 03/2012)
4.	Koutlas, Ioannis G: 2 articles (06/2014 - 12/2006)
5.	Doll, Christian: 1 article (02/2022)
6.	Furth, Christian: 1 article (02/2022)
7.	Herden, Anna: 1 article (02/2022)
8.	Sabtan, Deema: 1 article (02/2022)
9.	Warnecke, Katja: 1 article (02/2022)
10.	Jin, Ying-Tai: 1 article (07/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calcifying Epithelial Odontogenic Tumor:

1.	Amyloid (Amyloid Fibrils)IBA 06/01/2000 - "We report a case of calcifying epithelial odontogenic tumor and investigate the nature of the amyloid, using histologic, immunohistochemical, and ultrastructural studies. " 10/01/1975 - "Ultrastructural study of amyloid material in the calcifying epithelial odontogenic tumor." 03/01/2020 - "Histologically, Pindborg tumor consists of three distinct histological compo-nents: sheets of polyhedral epithelial cells, amyloid like deposits, and calcifications. " 03/01/2011 - "Cells within the proliferating epithelial cell masses were positive for Notch1 and had an appearance reminiscent of calcifying epithelial odontogenic tumor with amyloid-like deposits. " 04/01/1990 - "Pindborg tumor is characterized by the production of large amounts of amyloid and the presence of calcified lamellar bodies. "
2.	AmelogeninIBA 03/01/1992 - "Amelogenin and enamelin were demonstrated in small mineralized foci and in the tumor cells surrounding them in adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), and calcifying odontogenic cyst (COC). " 03/01/2012 - "In this study, we have examined the presence and distribution of odontogenic ameloblast-associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). " 01/01/2023 - "Although pindborg tumor is the bonafide example of amyloid deposition in odontogenic tumors, this study concluded that amyloid may be deposited in traces to massive amounts in various odontogenic cysts and tumors, and it is significantly linked to odontogenic ameloblast-associated protein but not amelogenin matrix protein, since all amyloid cases were odontogenic ameloblast associated protein positive." 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "
3.	Proteins (Proteins, Gene)FDA Link 11/01/2003 - "Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein." 02/01/1980 - "The homogeneous acellular materials in the adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, and calcifying odontogenic cyst were examined histochemically for specific staining of amino acids and protein groups. " 03/01/2012 - "In this study, we have examined the presence and distribution of odontogenic ameloblast-associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). " 01/01/2023 - "Although pindborg tumor is the bonafide example of amyloid deposition in odontogenic tumors, this study concluded that amyloid may be deposited in traces to massive amounts in various odontogenic cysts and tumors, and it is significantly linked to odontogenic ameloblast-associated protein but not amelogenin matrix protein, since all amyloid cases were odontogenic ameloblast associated protein positive."
4.	Keratin-14 (Keratin 14)IBA 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "
5.	Keratins (Keratin)IBA 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "
6.	Insulin-Like Growth Factor I (IGF-1)IBA 04/01/2023 - "The aim of this study is to investigate the expression of IGF-1 in both calcifying epithelial odontogenic tumor (CEOT) and ameloblastoma. "
7.	Indicators and Reagents (Reagents)IBA 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "
8.	Insulin-Like PeptidesIBA 04/01/2023 - "Immunohistochemical study of insulin-like growth factor 1 in calcifying epithelial odontogenic tumor and ameloblastoma: experimental research."
9.	cholesteryl oleoyl carbonateIBA 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "
10.	MineralsIBA 01/01/2014 - "The Pindborg tumor mineral portion was found to be poorly crystalline and rich in HPO(4)(2-). " 12/01/1979 - "X-ray diffraction and electron spin resonance (ESR) analyses were conducted on calcifying epithelial odontogenic tumor (CEOT) associated with abundant calcification in order to compare its mineral structure with that of surrounding cortical bone. "

Therapies and Procedures

1.	Mandibular Reconstruction 03/01/2021 - "Mandibular Reconstruction Using Free Fibular Flap Graft Following Excision of Calcifying Epithelial Odontogenic Tumor."
2.	Oral Pathology 01/01/2020 - "With IRB approval, cases from the following entities were identified from archives of the UF Oral Pathology Biopsy Service (2005-2015): benign incidental odontogenic rest, dentigerous cyst, lateral periodontal cyst, calcifying odontogenic cyst, glandular odontogenic cyst, odontogenic keratocyst, orthokeratinized odontogenic cyst, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, and ameloblastoma. "
3.	Curettage 02/01/2013 - "The patient was a 34-year-old woman who had been previously diagnosed with Pindborg tumor and treated with curettage. "