Macrophagic myofasciitis

A rare inflammatory myopathy characterized by accumulation of MACROPHAGES in muscular FASCIA without muscle fiber necrosis. It may result from a reaction to intramuscular injections of aluminum-containing vaccines.

Also Known As:

Networked: 64 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Myalgia
2.	Fatigue
3.	Cognitive Dysfunction
4.	Muscular Diseases (Myopathy)
5.	Myositis (Idiopathic Inflammatory Myopathies)

Experts

1.	Gherardi, Romain K: 14 articles (07/2019 - 09/2002)
2.	Authier, François-Jérôme: 9 articles (09/2017 - 11/2003)
3.	Itti, Emmanuel: 7 articles (10/2018 - 11/2011)
4.	Van Der Gucht, Axel: 6 articles (10/2018 - 01/2015)
5.	Blanc-Durand, Paul: 5 articles (10/2018 - 01/2017)
6.	Gherardi, R K: 5 articles (02/2012 - 07/2000)
7.	Bachoud-Levi, Anne-Catherine: 4 articles (01/2018 - 11/2009)
8.	Cadusseau, Josette: 4 articles (06/2015 - 01/2014)
9.	Ragunathan-Thangarajah, Nilusha: 4 articles (01/2015 - 11/2013)
10.	Authier, F J: 4 articles (02/2012 - 07/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Macrophagic myofasciitis:

1.	aluminum sulfate (alum)IBA 06/17/2015 - "Concerns linked to alum particles have emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion in patients with myalgic encephalomyelitis, revealing an unexpectedly long-lasting biopersistence of alum within immune cells and a fundamental misconception of its biodisposition. " 01/01/2015 - "Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. " 02/01/2012 - "A small proportion of vaccinated people present with delayed onset of diffuse myalgia, chronic fatigue and cognitive dysfunction, and exhibit very long-term persistence of alum-loaded macrophages at the site of previous intramuscular (i.m.) immunization, forming a granulomatous lesion called macrophagic myofasciitis (MMF). " 01/01/2014 - "These conditions described as ASIA (Autoimmune/inflammatory Syndrome Induced by Adjuvants), include a condition characterized by macrophagic myofasciitis (MMF) assessing long-term persistence of vaccine derived-alum adjuvants into macrophages at sites of previous immunization. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 10/01/1999 - "Macrophagic myofasciitis: improvement with antibiotic therapy."
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/05/2000 - "Patients improved under corticosteroid therapy and/or immunomodulatory therapeutic A new inflammatory muscle disorder, characterized by a distinctive pathological pattern of macrophagic myofasciitis is emerging in France."
4.	AluminumIBA 11/01/2013 - "Distinctive clinical features in arthro-myalgic patients with and without aluminum hydroxyde-induced macrophagic myofasciitis: an exploratory study." 02/01/2020 - "Indirect toxicity of aluminum was suggested to explain macrophagic myofasciitis in humans in 2011, a disease that could be mediated by an autoimmune/autoinflammatory mechanism. " 07/03/2018 - "Muscle biopsy revealed an inflammatory infiltrate predominantly macrophagic with aluminium deposits suggestive of macrophagic myofasciitis (MMF). " 01/01/2005 - "Macrophagic myofasciitis (MMF) is known to be closely associated to vaccination containing aluminium as an adjuvant. " 01/01/2005 - "Their safety has nevertheless been questioned in France over the last few years following the demonstration that aluminium could persist for prolonged periods at the injection site, within macrophages gathered around the muscular fibres and forming a microscopic histological lesion called "macrophagic myofasciitis (MMF)". "
5.	VaccinesIBA 09/01/2020 - "1) To systematically review all original articles investigating the association of vaccines with gulf war illness, 2) To discuss gulf war illness, Macrophagic Myofasciitis, and post-HPV vaccination syndrome clinical similarities, 3) To discuss emergent pathogenetic mechanisms proposed for post-HPV vaccination syndrome that may be also relevant to gulf war illness and Macrophagic Myofasciitis. " 09/01/2020 - "Macrophagic Myofasciitis and post-HPV vaccination syndrome are two newer controversial vaccine-related disabling ailments. " 05/01/2006 - "AlOH3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background." 11/01/2005 - "Despite the wide use of vaccines in childhood, macrophagic myofasciitis was rarely observed in children and its characteristic histologic pattern could not be correlated with a distinctive clinical syndrome." 09/01/2020 - "post-HPV vaccination syndrome, Macrophagic Myofasciitis, and gulf war illness analogy suggests that some vaccines or multiple vaccinations in a very short period of time may induce, in susceptible individuals, chronic pain, fatigue and dyscognition. "
6.	hydroxide ionIBA 11/01/2009 - "Although rare, macrophagic myofasciitis has been reported following vaccination and is attributed to the aluminium hydroxide used as an adjuvant in some vaccines. " 12/01/2006 - "Macrophagic myofasciitis (MMF) is an uncommon inflammatory disorder of muscle believed to be due to persistence of vaccine-derived aluminium hydroxide at the site of injection. " 02/03/2005 - "The recent observation in human deltoid muscle of macrophage aggregates containing aluminium hydroxide spicules and termed Macrophagic Myofasciitis (MMF) has encouraged research on aluminium salts. " 09/01/2001 - "Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle." 11/01/2004 - "The study aimed at determining the presence of an oxidative stress in patients with macrophagic myofasciitis (MMF), a new inflammatory myopathy with suspected toxic etiology related to aluminium hydroxide-containing vaccines. "
7.	Thimerosal (Thiomersal)IBA 10/01/2005 - "In large controlled trials there was no proof that vaccination causes asthma, hepatitis-B-vaccination causes multiple sclerosis or macrophagic myofasciitis, Hib-vaccination causes diabetes mellitus, rubella-vaccination causes chronic arthritis, measles-mumps-rubella-vaccination causes gait disturbance or thiomersal causes autism. " 06/01/2002 - "macrophagic myofasciitis (aluminium), neurotoxicity (thimerosal), and new variant Creutzfeldt-Jakob disease (bovine-derived materials)] are discussed." 11/01/2005 - "Against this background, an international group of experts was convened to review the current points of view concerning the use of thimerosal as a preservative and its potential risks; the suggested link between thimerosal-containing vaccines and acute lymphoblastic leukemia; the alleged association between aluminum-containing vaccines/macrophagic myofasciitis and general systemic complaints; a possible link between vaccination and autoimmune pathology; and a hypothetical link between measles-mumps-rubella vaccination and autism. "
8.	Aluminum Hydroxide (Algeldrate)FDA Link 10/01/2018 - "Macrophagic myofasciitis (MMF) syndrome is a subtype of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome, characterized by the presence of stereotyped inflammatory lesions at muscle biopsy attesting the long-term persistence of aluminum hydroxide particles at the site of previous immunization. " 01/01/2015 - "Macrophagic myofasciitis (MMF) characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization has been reported with increasing frequency in the past 10 years. " 01/01/2014 - "Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. " 11/01/2011 - "Macrophagic myofasciitis (MMF) is characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. " 11/01/2009 - "Macrophagic myofasciitis (MMF) is an emerging condition, characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. "
9.	Vaccine AdjuvantsIBA 01/01/2005 - "[Vaccine adjuvants and macrophagic myofasciitis]." 02/01/2003 - "[Lessons from macrophagic myofasciitis: towards definition of a vaccine adjuvant-related syndrome]." 01/01/2003 - "[Vaccine adjuvants and macrophagic myofasciitis]." 01/01/2014 - "Macrophagic myofasciitis is a novel inflammatory myopathy ascribed to an ongoing local immune reaction to a vaccine adjuvant. " 10/15/2002 - "Identical twins with macrophagic myofasciitis: genetic susceptibility and triggering by aluminic vaccine adjuvants?"
10.	SiliconesIBA 12/01/2013 - "All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with post-vaccination phenomena and macrophagic myofasciitis syndrome. " 01/01/2016 - "There have been many cases of the appearance of autoantibodies and symptoms of disease after exposure to adjuvants, not only after breast augmentation with silicone implants, but also as a very rare vaccination side effect, such as Gulf war syndrome or macrophagic myofasciitis syndrome. " 04/01/2013 - "The main substances associated with ASIA are squalene (Gulf War syndrome), aluminum hydroxide (postvaccination phenomena, macrophagic myofasciitis) and silicone with siliconosis. " 04/01/2013 - "Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) has been recently proposed by Shoenfeld and Agmon-Levin as a new entity that comprises several conditions: the macrophagic-myofasciitis syndrome, the Gulf War syndrome, silicosis and post-vaccination phenomena, autoimmunity related to infectious fragments, hormones, aluminum, silicone, squalene oil, and pristane. "

Therapies and Procedures

1.	Therapeutics 10/01/1999 - "Macrophagic myofasciitis: improvement with antibiotic therapy." 02/05/2000 - "Patients improved under corticosteroid therapy and/or immunomodulatory therapeutic A new inflammatory muscle disorder, characterized by a distinctive pathological pattern of macrophagic myofasciitis is emerging in France."
2.	Intramuscular Injections 05/01/2001 - "Macrophagic myofasciitis (MMF), a condition newly recognized in France, is manifested by diffuse myalgias and characterized by highly specific myopathological alterations which have recently been shown to represent an unusually persistent local reaction to intramuscular injections of aluminium-containing vaccines. " 10/01/2012 - "The pathogenic role of aluminium hydroxide is now recognized by the presence of chronic fatigue syndrome, macrophagic myofasciitis and subcutaneous pseudolymphoma, linked to intramuscular injection of aluminium hydroxide-containing vaccines. "