Juvenile osteoporosis

Idiopathic osteoporosis of childhood or adolescence characterized by normal SCLERA (unlike OSTEOGENESIS IMPERFECTA), Low plasma CALCITROL (1,25-dihydroxycholecalciferol), normal serum CALCIFEDIOL (25-hydroxycholecalciferol), and normal renal function. The condition usually improves with the onset of puberty and it may be hereditary (autosomal recessive). OMIM: 259750

Also Known As:

Networked: 40 relevant articles (5 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteogenesis Imperfecta (Lobstein Disease)
2.	Osteoporosis
3.	Bone Diseases (Bone Disease)
4.	Persistent Hyperplastic Primary Vitreous
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Experts

1.	Amizuka, Norio: 2 articles (01/2020 - 11/2018)
2.	Fujita, Ryo: 2 articles (01/2020 - 11/2018)
3.	Fukuda, Chie: 2 articles (01/2020 - 11/2018)
4.	Hasegawa, Tomoka: 2 articles (01/2020 - 11/2018)
5.	Hiruma, Yoshiharu: 2 articles (01/2020 - 11/2018)
6.	Iwasaki, Norimasa: 2 articles (01/2020 - 11/2018)
7.	Okada, Akiko: 2 articles (01/2020 - 11/2018)
8.	Ota, Masahiro: 2 articles (01/2020 - 11/2018)
9.	Sato, Dai: 2 articles (01/2020 - 11/2018)
10.	Takahata, Masahiko: 2 articles (01/2020 - 11/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Juvenile osteoporosis:

1.	CalciumIBA 08/12/1977 - "Calcium metabolism was studied in a 12-year-old girl preseting with idiopathic juvenile osteoporosis. " 07/01/1961 - "Juvenile osteoporosis (osteogenesis imperfecta)--a calcium deficiency." 11/28/1988 - "[Urinary excretion of calcium after administration of 1 alpha-hydroxyvitamin D3 in idiopathic juvenile osteoporosis]." 05/01/1987 - "Prolonged multimodality therapy with calcitonin, anabolic steroids, active forms of Vitamin D3, calcium agents, physiotherapy and exercise therapy was found effective in juvenile osteoporosis." 07/01/2003 - "Bone quality by quantitative ultrasound and fracture rate were assessed in 135 (64 males) children and adolescents aged 3-21 y with bone and mineral disorders such as chronic anticonvulsants or glucocorticoids treatment, juvenile rheumatoid arthritis, celiac disease, paucity of intrahepatic bile ducts, autoimmune hepatitis, genetic diseases, idiopathic juvenile osteoporosis, disuse osteoporosis, beta-thalassemia major, survivors of acute lymphoblastic leukemia, liver transplantation, calcium deficiency, and nutritional or X-linked hypophosphatemic rickets. "
2.	GlucocorticoidsIBA 01/01/2020 - "Effective treatment of juvenile osteoporosis, which is frequently caused by glucocorticoid (GC) therapy, has not been established due to limited data regarding the efficacy and adverse effects of antiresorptive therapies on the growing skeleton. " 07/01/2003 - "Bone quality by quantitative ultrasound and fracture rate were assessed in 135 (64 males) children and adolescents aged 3-21 y with bone and mineral disorders such as chronic anticonvulsants or glucocorticoids treatment, juvenile rheumatoid arthritis, celiac disease, paucity of intrahepatic bile ducts, autoimmune hepatitis, genetic diseases, idiopathic juvenile osteoporosis, disuse osteoporosis, beta-thalassemia major, survivors of acute lymphoblastic leukemia, liver transplantation, calcium deficiency, and nutritional or X-linked hypophosphatemic rickets. "
3.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 11/01/1988 - "Effect of calcitonin replacement therapy in idiopathic juvenile osteoporosis." 05/01/1987 - "A tendency to a decrease in the levels of calcitonin and parathyroid hormone was found in juvenile osteoporosis; mild signs of hypogonadism (secondary) and a relative decrease in hypophyseal somatotropic activity promoted its detection. " 11/01/1988 - "An 8-year-old boy with idiopathic juvenile osteoporosis and multiple fractures had three abnormalities of bone mineral metabolism: calcitonin deficiency, elevated serum calcitriol concentrations, and hypercalciuria. " 05/01/1987 - "Prolonged multimodality therapy with calcitonin, anabolic steroids, active forms of Vitamin D3, calcium agents, physiotherapy and exercise therapy was found effective in juvenile osteoporosis."
4.	Clodronic Acid (Clodronate)IBA 01/01/2005 - "Parenteral clodronate therapy is effective in managing severe idiopathic juvenile osteoporosis."
5.	Cholecalciferol (Vitamin D3)FDA Link 05/01/1987 - "Prolonged multimodality therapy with calcitonin, anabolic steroids, active forms of Vitamin D3, calcium agents, physiotherapy and exercise therapy was found effective in juvenile osteoporosis."
6.	Anabolic Androgenic SteroidsIBA 05/01/1987 - "Prolonged multimodality therapy with calcitonin, anabolic steroids, active forms of Vitamin D3, calcium agents, physiotherapy and exercise therapy was found effective in juvenile osteoporosis."
7.	Diphosphonates (Bisphosphonates)IBA 01/01/2015 - "We describe the MR imaging appearance of the spine that, to our knowledge, has not been previously addressed in a child with idiopathic juvenile osteoporosis who had received bisphosphonates and emphasize the evolution of the radiographic findings of the spine and pelvis over a four-year period. " 01/01/2015 - "Radiographic and MR Imaging Findings of the Spine after Bisphosphonate Treatment, in a Child with Idiopathic Juvenile Osteoporosis." 06/01/2002 - "On the other hand, our results confirm that bisphosphonates can be used safely in the treatment of disorders that affect the growing skeleton, such as in juvenile osteoporosis." 11/01/1985 - "Characteristics and bisphosphonate treatment of a patient with juvenile osteoporosis." 01/01/2020 - "Juvenile osteoporosis with calvarial doughnuts: Progressive high-turnover bone loss responsive to bisphosphonate therapy."
8.	Risedronic Acid (Actonel)FDA LinkGeneric 06/01/2011 - "The objective of the current study was to determine whether treatment with a bisphosphonate (risedronate, Ris), which reduces fractures in postmenopausal as well as in juvenile osteoporosis, was able to improve bone quality and reduce vertebral fractures in mice overexpressing Runx2. "
9.	Calcitriol (Calcijex)FDA LinkGeneric 07/01/1992 - "Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test." 10/01/1982 - "Calcitriol deficiency in idiopathic juvenile osteoporosis." 04/01/1991 - "Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis." 11/01/1988 - "An 8-year-old boy with idiopathic juvenile osteoporosis and multiple fractures had three abnormalities of bone mineral metabolism: calcitonin deficiency, elevated serum calcitriol concentrations, and hypercalciuria. "
10.	MineralsIBA 04/01/1991 - "Mineral metabolism and calcitriol therapy in idiopathic juvenile osteoporosis." 11/01/1988 - "An 8-year-old boy with idiopathic juvenile osteoporosis and multiple fractures had three abnormalities of bone mineral metabolism: calcitonin deficiency, elevated serum calcitriol concentrations, and hypercalciuria. " 07/01/2003 - "Bone quality by quantitative ultrasound and fracture rate were assessed in 135 (64 males) children and adolescents aged 3-21 y with bone and mineral disorders such as chronic anticonvulsants or glucocorticoids treatment, juvenile rheumatoid arthritis, celiac disease, paucity of intrahepatic bile ducts, autoimmune hepatitis, genetic diseases, idiopathic juvenile osteoporosis, disuse osteoporosis, beta-thalassemia major, survivors of acute lymphoblastic leukemia, liver transplantation, calcium deficiency, and nutritional or X-linked hypophosphatemic rickets. "

Therapies and Procedures

1.	Therapeutics 11/01/2018 - "Thus, anti-Siglec-15 therapy could be a safe and effective for juvenile osteoporosis." 11/01/2018 - "This prompted us to develop an anti-Siglec-15 therapy for juvenile osteoporosis because most anti-resorptive drugs have potential adverse effects on skeletal growth. " 09/01/2000 - "There are scant data to date on the use of GH therapy in osteogenesis imperfecta (OI) or in idiopathic juvenile osteoporosis (IJO). " 01/01/2020 - "Effective treatment of juvenile osteoporosis, which is frequently caused by glucocorticoid (GC) therapy, has not been established due to limited data regarding the efficacy and adverse effects of antiresorptive therapies on the growing skeleton. " 01/01/2005 - "Parenteral clodronate therapy is effective in managing severe idiopathic juvenile osteoporosis."
2.	Drug Therapy (Chemotherapy) 12/01/2005 - "In some cases, such as idiopathic juvenile osteoporosis, the rule is spontaneous resolution, and the advisability of an aggressive drug therapy is discussed." 10/01/2020 - "BPs were used to alleviate bone pain in a wide variety of pediatrics conditions such as osteogenesis imperfecta, secondary osteoporosis, osteonecrosis related to chemotherapy, chronic non-bacterial osteitis, idiopathic juvenile osteoporosis, unresectable benign bone tumor, and cancer-related pain. "
3.	Exercise Therapy (Therapy, Exercise) 05/01/1987 - "Prolonged multimodality therapy with calcitonin, anabolic steroids, active forms of Vitamin D3, calcium agents, physiotherapy and exercise therapy was found effective in juvenile osteoporosis."
4.	Liver Transplantation 07/01/2003 - "Bone quality by quantitative ultrasound and fracture rate were assessed in 135 (64 males) children and adolescents aged 3-21 y with bone and mineral disorders such as chronic anticonvulsants or glucocorticoids treatment, juvenile rheumatoid arthritis, celiac disease, paucity of intrahepatic bile ducts, autoimmune hepatitis, genetic diseases, idiopathic juvenile osteoporosis, disuse osteoporosis, beta-thalassemia major, survivors of acute lymphoblastic leukemia, liver transplantation, calcium deficiency, and nutritional or X-linked hypophosphatemic rickets. "