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Multi-centric Castleman's Disease

A rare systemic form of CASTLEMAN'S DISEASE, in contrast to the unicentric form which is localized to a single lymph node. Patients often present with nonspecific symptoms, such as fever, fatigue, weight loss, and enlarged lymph nodes. It is associated with increased expression of INTERLEUKIN-6 and a tendency to develop LYMPHOMA. OMIM: 148000
Also Known As:
HHV-8-Associated Multicentric Castleman Disease; HHV-8-negative MCD; HHV-8-negative idiopathic multicentric Castleman disease; HHV8 Multicentric Castleman Disease; Idiopathic multicentric Castleman's disease; KSHV Muticentric Castleman Disease; KSHV-Associated Multicentric Castleman Disease; Multicentric Castleman's disease; Multicentric plasma cell variant of Castleman's disease; Plasmablastic multicentric Castleman disease; TAFRO HHV-8-negative multicentric Castleman disease.; TAFRO syndrome; thrombocytopenia anasarca fever renal dysfunction and organomegaly syndrome
Networked: 370 relevant articles (47 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Kaposi Sarcoma (Kaposi's Sarcoma)
2. Multi-centric Castleman's Disease
3. Castleman Disease (Castleman's Disease)
4. Cardiomyopathies (Cardiomyopathy)
5. Primary Effusion Lymphoma

Experts

1. Sato, Yasuharu: 13 articles (06/2022 - 04/2009)
2. Yoshino, Tadashi: 12 articles (10/2019 - 01/2004)
3. Kawabata, Hiroshi: 11 articles (05/2022 - 06/2007)
4. Masaki, Yasufumi: 11 articles (05/2022 - 04/2010)
5. Takai, Kazue: 9 articles (05/2022 - 02/2016)
6. Nicholas, John: 9 articles (01/2021 - 09/2003)
7. Kurose, Nozomu: 8 articles (01/2021 - 01/2013)
8. Kojima, Masaru: 8 articles (03/2019 - 04/2009)
9. Aoki, Sadao: 7 articles (05/2022 - 06/2016)
10. Sakai, Tomoyuki: 7 articles (05/2022 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multi-centric Castleman's Disease:
1. Rituximab (Mabthera)FDA Link
2. tocilizumab (atlizumab)FDA Link
3. Adrenal Cortex Hormones (Corticosteroids)IBA
4. SteroidsIBA
5. Cyclosporine (Ciclosporin)FDA LinkGeneric
6. Monoclonal AntibodiesIBA
7. Prednisolone (Predate)FDA LinkGeneric
8. GlucocorticoidsIBA
9. ValganciclovirFDA Link
10. Bortezomib (Velcade)FDA Link

Therapies and Procedures

1. Therapeutics
2. Highly Active Antiretroviral Therapy (HAART)
3. Drug Therapy (Chemotherapy)
4. Splenectomy
5. Combination Drug Therapy (Combination Chemotherapy)