Single upper central incisor

A hereditary autosomal dominant condition characterized primarily by single (unpaired) deciduous and permanent maxillary central incisors and short stature. Growth hormone deficiencies may also be present. Mutations in the SHH gene have been identified. OMIM: 147250

Also Known As:

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Holoprosencephaly (Arhinencephaly)
2.	Microcephaly
3.	Kidney Diseases (Kidney Disease)
4.	Duane Retraction Syndrome (Duane Syndrome)
5.	Coloboma (Colobomas)

Experts

1.	Moser, Lorenz: 1 article (07/2021)
2.	Schneider, Ute E M: 1 article (07/2021)
3.	Attin, Thomas: 1 article (08/2020)
4.	Bernardi, Guglielmo: 1 article (08/2020)
5.	Bernardi, Sara: 1 article (08/2020)
6.	Bianchi, Serena: 1 article (08/2020)
7.	Hellwig, Elmar: 1 article (08/2020)
8.	Karygianni, Lamprini: 1 article (08/2020)
9.	Tchorz, Jörg Philipp: 1 article (08/2020)
10.	Ayash, Ghada: 1 article (03/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Single upper central incisor:

1.	Growth Hormone (Somatotropin)IBA 01/01/2013 - "Solitary median maxillary central incisor, a clinical predictor of hypoplastic anterior pituitary, ectopic neurohypophysis and growth hormone deficiency." 04/01/2003 - "A 4-year-old Italian child with the association of a solitary median maxillary central incisor, growth hormone deficiency, Duane retraction syndrome and a duplicated thumb phalanx is described." 04/01/2003 - "Solitary median maxillary central incisor, Duane retraction syndrome, growth hormone deficiency and duplicated thumb phalanx: a case report."
2.	Indicators and Reagents (Reagents)IBA 05/01/1992 - "We show a further evidence of a single central maxillary incisor as an indicator of potential holoprosencephaly in the next generation, confirming an autosomal dominant trait with wide variety in penetrance and expressivity." 10/01/1987 - "We show the significance of a single central maxillary incisor as an indicator or potential holoprosencephaly in the next generation, even if other relatives are apparently normal."
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/2016 - "Loss of Sostdc1, a growth factor paralogous to Sost, causes the formation of ectopic incisors, fused molars, abnormal hair follicles, and resistance to kidney disease. "
4.	Stainless Steel (Steel, Stainless)IBA 07/01/2001 - "With respect to the fused incisors, these were split and root canals treatment was performed for all three incisors which were then restored with stainless steel crowns with esthetic facings."
5.	Retinaldehyde (Retinal)IBA 01/01/1993 - "One had left choanal atresia, retinal coloboma, a single central maxillary incisor, microcephaly, short stature, and learning problems. "
6.	zirconium oxide (zirconia)IBA 03/01/2020 - "Twenty-four zirconia crown restorations were fabricated to restore single central maxillary incisor for 8 patients, divided into 3 groups according to color and type of zirconia used (white Zr core, colored Zr core and monolithic HT Zrcowns). "

Therapies and Procedures

1.	Crowns (Crown, Dental) 07/01/2021 - "In contrast, the present patient was treated with extraction of the solitary median maxillary central incisor and orthodontic space closure with subsequent minimally invasive restorations in order to avoid looming esthetic or periodontal sequelae associated with any type of fixed bridgework or implant-borne crowns in the sensitive maxillary anterior area-which is especially indicated in young girls with a hyperdivergent growth pattern." 07/01/2001 - "With respect to the fused incisors, these were split and root canals treatment was performed for all three incisors which were then restored with stainless steel crowns with esthetic facings."
2.	Orthodontic Space Closure 07/01/2021 - "Orthodontic space closure in a young female patient with solitary median maxillary central incisor syndrome." 07/01/2021 - "In contrast, the present patient was treated with extraction of the solitary median maxillary central incisor and orthodontic space closure with subsequent minimally invasive restorations in order to avoid looming esthetic or periodontal sequelae associated with any type of fixed bridgework or implant-borne crowns in the sensitive maxillary anterior area-which is especially indicated in young girls with a hyperdivergent growth pattern."
3.	Transplantation 12/01/2014 - "Premolar transplantation in a patient with solitary median maxillary central incisor syndrome."
4.	Therapeutics 08/01/2020 - " and Methods: A systematic review regarding the therapy of primary fused incisors in the mandible was performed and the obtained data were assessed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. "