Grover's disease

Acute eruption of small itchy red papules, especially in the middle of the chest and back, that are characterized by acantholysis. The eruption is usually triggered by sweating or heat and may last 10-12 months. It is most common in men over age 40.

Also Known As:

Networked: 86 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Grover's disease
2.	Pemphigus (Pemphigus Vulgaris)
3.	Bullous Pemphigoid (Pemphigoid)
4.	Cutaneous Lupus Erythematosus
5.	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)

Experts

1.	Barbara, Lydia: 2 articles (01/2017 - 01/2016)
2.	Bernatchez, Chantale: 2 articles (01/2017 - 01/2016)
3.	Curry, Jonathan L: 2 articles (01/2017 - 01/2016)
4.	Diab, Adi: 2 articles (01/2017 - 01/2016)
5.	Fa'ak, Faisal: 2 articles (01/2017 - 01/2016)
6.	Haymaker, Cara: 2 articles (01/2017 - 01/2016)
7.	Hudgens, Courtney W: 2 articles (01/2017 - 01/2016)
8.	Hwu, Patrick: 2 articles (01/2017 - 01/2016)
9.	McQuail, Natalie: 2 articles (01/2017 - 01/2016)
10.	Sirmans, Elizabeth: 2 articles (01/2017 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Grover's disease:

1.	AcitretinFDA Link 03/15/2019 - "Persistent generalized Grover disease: complete remission after treatment with oral acitretin." 03/01/2023 - "Novel use of acitretin for posttransplant Grover's disease and cutaneous graft versus host disease." 01/01/2004 - "Grover's disease: successful treatment with acitretin and calcipotriol." 11/22/2023 - "Methotrexate Versus Acitretin for Grover's Disease Refractory to Topical Therapies."
2.	Trichloroacetic AcidIBA 08/01/2006 - "Effective treatment of persistent Grover's disease with trichloroacetic acid peeling."
3.	EtretinateFDA Link 01/01/1987 - "Due to its influence on dermal inflammatory processes and immunomodulation of the tissue response, etretinate is effective in cutaneous lupus erythematosus, certain bullous disorders like pemphigus herpetiformis, the persistent variant of Grover's disease, dermatitis herpetiformis, and bullous pemphigoid. "
4.	AcidsIBA 06/01/2013 - "Successful novel treatment of recalcitrant transient acantholytic dermatosis (Grover disease) using red light 5-aminolevulinic acid photodynamic therapy."
5.	Rituximab (Mabthera)FDA Link 03/01/2008 - "Remission of transient acantholytic dermatosis after the treatment with rituximab for follicular lymphoma."
6.	Immunoglobulin A (IgA)IBA 01/01/1981 - "The patient also suffered from paraproteinemia (increased IgA with M-component) and transient acantholytic dermatosis resembling pemphigus erythematosus. " 01/01/2012 - "Cases of limited numbers in our study were linear IgA bullous dermatitis in 2 cases, Grover's disease in 1 case, epidermolysis bullosa acquisata in 5 cases and, Hailey-Hailey disease in 1 case. " 05/01/1993 - "Hereditary acantholytic diseases and other diseases such as bullous pemphigoid, intraepidermal IgA dermatosis, eczema, herpes, and transient acantholytic dermatosis show a similar pattern to normal skin. "
7.	calcipotriene (calcipotriol)FDA LinkGeneric 01/01/1998 - "Successful treatment of Grover's disease with calcipotriol." 05/01/1995 - "Treatment of Grover's disease with calcipotriol (Dovonex)" 01/01/2004 - "Grover's disease: successful treatment with acitretin and calcipotriol." 11/01/2020 - "Grover's disease successfully treated with calcipotriene/betamethasone dipropionate ointment."
8.	Isotretinoin (Accutane)FDA LinkGeneric 02/01/1990 - "Transient acantholytic dermatosis treated with isotretinoin." 01/01/1989 - "Transient acantholytic dermatosis treated with isotretinoin." 06/01/1985 - "Four patients with Grover's disease were treated with isotretinoin. " 06/01/1985 - "Grover's disease treated with isotretinoin. "
9.	Proteins (Proteins, Gene)FDA Link 03/01/1995 - "Junctional proteins of keratinocytes in Grover's disease, Hailey-Hailey's disease and Darier's disease." 12/01/1995 - "Proteins involved in the formation of desmosomes and simpler adherens junctions were studied in three types of non-immune acantholytic diseases; specifically, four cases of Grover's disease (GD), one case of Hailey-Hailey's disease (HHD) and one case of Darier's disease (DD), and these were compared to two cases of immune-mediated acantholytic disease pemphigus vulgaris (PV). " 03/01/1991 - "There was normal expression of desmosomal proteins and glycoproteins at the periphery of the keratinocytes in the perilesional skin in Darier's disease, in Hailey-Hailey disease and in transient acantholytic dermatosis. "
10.	IpilimumabIBA 01/01/2016 - "This case suggests that Grover's disease is an irAE induced by Ipilimumab. " 01/01/2016 - "We report an additional case of ipilimumab-induced Grover's disease. " 01/01/2016 - "Grover's disease is an uncommon dermatologic condition with unclear pathogenesis previously reported as an irAE with ipilimumab. " 11/01/2014 - "First report of ipilimumab-induced Grover disease." 01/01/2016 - "Here we report the uncommon event of a drug-induced transient acantholytic dermatosis (Grover's disease) in a 73-year-old Caucasian male treated with ipilimumab for metastatic melanoma. "

Therapies and Procedures

1.	Radiotherapy 04/01/2019 - "Accordingly, we present, to our knowledge, the first reported case of recalcitrant Grover's disease treated successfully with radiotherapy. " 04/01/2003 - "The aim of this work, synthesized from personal case reports and a review of literature is to describe cutaneous complications of radiation therapy (except radiation-induced cancers): known and frequent such as radiation dermatitis or less frequent, beginning or strictly limited on irradiated skin areas: acne, infectious diseases, dyskeratosis, Grover's disease, sub-cutaneous pustulosis, cutaneous lichen, morphea, autoimmune bullous dermatosis, subacute cutaneous lupus erythematosus. "
2.	Photochemotherapy (Photodynamic Therapy) 01/01/1984 - "Response of transient acantholytic dermatosis to photochemotherapy." 06/01/2013 - "Successful novel treatment of recalcitrant transient acantholytic dermatosis (Grover disease) using red light 5-aminolevulinic acid photodynamic therapy."
3.	Aftercare (After-Treatment) 03/15/2019 - "Persistent generalized Grover disease: complete remission after treatment with oral acitretin." 09/01/1997 - "Transient acantholytic dermatosis after treatment with 2-chlorodeoxyadenosine."
4.	Immunomodulation 01/01/1987 - "Due to its influence on dermal inflammatory processes and immunomodulation of the tissue response, etretinate is effective in cutaneous lupus erythematosus, certain bullous disorders like pemphigus herpetiformis, the persistent variant of Grover's disease, dermatitis herpetiformis, and bullous pemphigoid. "
5.	Drug Therapy (Chemotherapy) 11/01/2020 - "Chemotherapy-associated Grover disease is reported most frequently in association with cytotoxic chemotherapies, followed by small molecule inhibitors. " 11/01/2020 - "Grover Disease Associated With Chemotherapy: Review of Potential Pathophysiology, Current Treatments, and Future Directions." 01/01/2017 - "Role of Immune Status in Chemotherapy-Induced Transient Acantholytic Dermatosis." 02/01/2014 - "Grover disease usually affects the trunk and may be related to the elimination of chemotherapy agents by sweating. " 09/01/2007 - "Clinicopathological spectrum of chemotherapy induced Grover's disease."