Ossification of the posterior longitudinal ligament of the spine

A hereditary ossification of the longitudinal spinal ligament (cervical and thoracic spine) that is common in Japanese and Asian populations in persons over 50 years of age. Patients may present with SPINAL CORD COMPRESSION; MYELOPATHY, and HYPERREFLEXIA. OMIM: 602475

Also Known As:

Networked: 21 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Vascular System Injuries
2.	Atherosclerosis
3.	Hearing Loss (Hearing Impairment)
4.	Spinal Cord Diseases
5.	Osteoarthritis

Experts

1.	Toh, Satoshi: 2 articles (01/2008 - 09/2006)
2.	Yokoyama, Toru: 2 articles (01/2008 - 09/2006)
3.	Ikeda, Ryuji: 2 articles (09/2006 - 03/2006)
4.	Inoue, Ituro: 2 articles (09/2006 - 03/2006)
5.	Tsukahara, So: 2 articles (09/2006 - 03/2006)
6.	Kawaguchi, Hiroshi: 2 articles (08/2002 - 01/2002)
7.	Koshizuka, Yu: 2 articles (08/2002 - 01/2002)
8.	Nakamura, Kozo: 2 articles (08/2002 - 01/2002)
9.	Ogata, Naoshi: 2 articles (08/2002 - 01/2002)
10.	Seichi, Atsushi: 2 articles (08/2002 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ossification of the posterior longitudinal ligament of the spine:

1.	Interleukin-15 (Interleukin 15)IBA 11/12/2014 - "Previous studies reported the association between single nucleotide polymorphism (SNP) of IL15 receptor alpha (IL15RA) gene with susceptibility to ossification of the posterior longitudinal ligament of the spine (OPLL). "
2.	VimentinIBA 11/01/2014 - "The aim of this study was to investigate the potential role of vimentin in the signal transduction pathways initiated by mechanical stimulation that contribute to ossification of the posterior longitudinal ligament of the spine (OPLL). "
3.	Collagen Type XIIBA 05/01/2001 - "Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine." 01/01/2001 - "Gender-specific haplotype association of collagen alpha2 (XI) gene in ossification of the posterior longitudinal ligament of the spine." 02/18/2022 - "Variants in the COL11A2 gene, which encodes collagen type XI alpha 2 chain, has been reported to cause hearing loss and has been associated with osteoarthritis and ossification of the posterior longitudinal ligament of the spine. "
4.	Calcitriol Receptors (Calcitriol Receptor)IBA 07/15/2008 - "FokI variant of vitamin D receptor gene and factors related to atherosclerosis associated with ossification of the posterior longitudinal ligament of the spine: a multi-hospital case-control study." 08/15/2002 - "To determine the association of restriction fragment length polymorphisms of estrogen receptor, vitamin D receptor, parathyroid hormone, and interleukin-1alpha and -1beta with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity. "
5.	Complementary DNA (cDNA)IBA 09/15/2006 - "To better understand the molecular pathogenesis of OPLL (ossification of the posterior longitudinal ligament) of the spine, an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from OPLL patients. " 03/01/2006 - "To understand the molecular pathogenesis of ossification of the posterior longitudinal ligament of the spine (OPLL), an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from OPLL patients to understand the molecular pathogenesis of OPLL. "
6.	N-(3-pyridyl)-3-phenylsuccinimideIBA 06/01/1999 - "Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)." 07/01/1998 - "Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine."
7.	Interleukin-1beta (Interleukin 1 beta)IBA 08/15/2002 - "Estrogen receptor (P = 0.007) and interleukin-1beta (P = 0.001) polymorphisms exhibited different distributions between patients with ossification of the posterior longitudinal ligament of the spine and control subjects in women, but not in men. "
8.	Interleukin-1alpha (Interleukin 1 alpha)IBA 08/15/2002 - "To determine the association of restriction fragment length polymorphisms of estrogen receptor, vitamin D receptor, parathyroid hormone, and interleukin-1alpha and -1beta with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity. "
9.	Toll-Like Receptor 5IBA 01/01/2011 - "Association of toll-like receptor 5 gene polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine in korean population."
10.	Untranslated RNA (Noncoding RNA)IBA 01/01/2023 - "A novel CCDC91 isoform associated with ossification of the posterior longitudinal ligament of the spine works as a non-coding RNA to regulate osteogenic genes."

Therapies and Procedures

1.	X-Ray Film 11/01/1989 - "To study the genetic background in ossification of the posterior longitudinal ligament of the spine (OPLL), 1,030 relatives of probands with cervical OPLL in 347 families were investigated by observing their spinal x-ray films, and the following results were obtained. "
2.	Punctures 06/01/2015 - "Although an 84-year-old patient did not have any coagulopathy and there was no vascular injury at the time of epidural puncture, epidural hematoma developed late in onset Ossification of the posterior longitudinal ligament of the spine was suspected as a potential cause. "