Lipodermatosclerosis

08/01/1990 - "The study fails to yield evidence suggesting that an oxygen diffusion barrier exists in lipodermatosclerosis."
02/01/1995 - "Transcutaneous oxygen pressure was uniformly reduced in lipodermatosclerosis (p < 0.02). "
04/01/1991 - "Although fibrinolytic enhancement caused a reduction in area of lipodermatosclerosis, no evidence of any effect on a possible oxygen diffusion block was indicated."
04/01/1991 - "The area of lipodermatosclerosis was measured at monthly intervals and transcutaneous oxygen tension within the liposclerotic area was measured at 3-monthly intervals. "
10/01/1995 - "Severe morphological capillary changes and a significant reduction of the mean transcutaneous oxygen tension values were found in conjunction with lipodermatosclerosis and white atrophy and in the areas surrounding venous ulcers. "

06/01/1986 - "The clearance of 125I-labelled fibrin from the subcutaneous tissue of limbs with lipodermatosclerosis."
08/01/2000 - "This study investigated the possibility that pericapillary fibrin deposition, found in the calf skin of patients with venous ulceration and lipodermatosclerosis, might already be present in the dermis of the gaiter area of apparently healthy limbs before any skin changes were visible. "
08/01/2000 - "The presence of significant numbers of pericapillary fibrin deposits within the dermis of the gaiter skin has been demonstrated in 84% of this cohort of 'at risk' limbs before there is any evidence of clinical lipodermatosclerosis."
06/01/1986 - "The inability to clear subcutaneous fibrin may be an aetological factor of lipodermatosclerosis."
10/16/1982 - "Lipodermatosclerosis is synonymous with pericapillary fibrin deposition and is associated with, and probably secondary to, both a persistently raised venous pressure and an increase in the size of the dermal capillary bed. "

10/30/2019 - "Oxandrolone may be a useful and safe treatment for patients with acute lipodermatosclerosis."
10/30/2019 - "Oxandrolone for treatment of lipodermatosclerosis: case report."
09/01/2000 - "Treatment of lipodermatosclerosis with oxandrolone in a patient with stanozolol-induced hepatotoxicity."

01/05/1980 - "Treatment with or without stanozolol caused the area of lipodermatosclerosis to decrease, but the rate of healing when patients took stanozolol was double that when they took the placebo, and this was assumed to be biologically important. "
08/13/1977 - "Fourteen patients with longstanding lipodermatosclerosis of their lower legs, secondary to venous disease in 11, were treated for three months with stanozolol, a drug that enhances fibrinolytic activity. "
02/28/2008 - "Acute lipodermatosclerosis: an open clinical trial of stanozolol in patients unable to sustain compression therapy."
01/05/1980 - "Stanozolol is valuable in treating intractable lipodermatosclerosis, giving relief of pain and reducing induration, inflammation, tenderness, and pigmentation."
08/01/1995 - "Stanozolol is approved for use in the treatment of hereditary angioedema, but numerous reports have detailed the effectiveness of this agent in the treatment of urticaria, Raynaud's phenomenon, and, more recently, cryofibrinogenemia and lipodermatosclerosis. "

03/01/2015 - "Anabolic steroids have been used to treat lower extremity ulcerations, including venous and cryofibrinogenemic ulcers and lipodermatosclerosis (LDS). "
01/05/1980 - "The value of fibrinolytic enhancement with an anabolic steroid (stanozolol) combined with elastic stockings in treating venous lipodermatosclerosis was assessed in a six-month double-blind cross-over trial. "
03/01/2015 - "Liver enzymes and lipid levels in patients with lipodermatosclerosis and venous ulcers treated with a prototypic anabolic steroid (stanozolol): a prospective, randomized, double-blinded, placebo-controlled trial."

03/01/2015 - "Liver enzymes and lipid levels in patients with lipodermatosclerosis and venous ulcers treated with a prototypic anabolic steroid (stanozolol): a prospective, randomized, double-blinded, placebo-controlled trial."

11/01/2009 - "In the present study, the contribution of these endothelium-specific ligand/receptor systems in tissue samples of lipodermatosclerosis was evaluated. "

03/01/2015 - "Liver enzymes and lipid levels in patients with lipodermatosclerosis and venous ulcers treated with a prototypic anabolic steroid (stanozolol): a prospective, randomized, double-blinded, placebo-controlled trial."

05/01/2019 - "This study demonstrates the beneficial effect of copper on lipodermatosclerosis secondary to chronic venous disease with reduction in surface area but no benefit on symptoms. "
05/01/2019 - "The aim of this study was to investigate the impact of copper on lipodermatosclerosis. "
05/01/2019 - "Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial."

10/01/1999 - "In the same pool of collagens an increase in collagen III content was observed as compared with controls (lipodermatosclerosis 14.5% +/- 1.6, control 10.3% +/- 1.6, p < 0.001). "
10/01/1996 - "We studied the molecular packing of collagen fibrils by x-ray diffraction in skin specimens of patients with lipodermatosclerosis and in controls. "
01/01/1991 - "In severe CVI with lipodermatosclerosis a significant increase of the collagen IV layer was observed. "
05/01/1999 - "Lipodermatosclerosis is characterized by fibrous scar tissue of the reticular dermis built up of collagen bundles and loss of cellular components, whereas venous ulceration is characterized by total loss of epidermis and partially of matrix structures in the upper dermis. "
08/01/2001 - "Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma."

09/01/2011 - "There was one case (90 patients included) in the compression and HR (1 g) group and no DVT in group 3. The outcome in groups 2 and 3 was significantly better (0.05) than in group 1. The need for surgery or sclerotherapy (for larger varicose veins), the occurrence of lipodermatosclerosis and ulcerations were significantly lower in the HR groups with a better outcome in the higher dose group (P<0.05). "

05/01/2019 - "Compression stockings are the primary treatment for lipodermatosclerosis secondary to chronic venous disease, but do not improve the skin condition. "
02/01/2000 - "Lipodermatosclerosis and compression stockings."
12/01/1998 - "Removal of dermal edema with class I and II compression stockings in patients with lipodermatosclerosis."
05/01/2019 - "Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial."
01/05/1980 - "The value of fibrinolytic enhancement with an anabolic steroid (stanozolol) combined with elastic stockings in treating venous lipodermatosclerosis was assessed in a six-month double-blind cross-over trial. "

10/01/2010 - "The initial search terms 'varicose vein', 'venous ulcer', 'venous disease' and 'lipodermatosclerosis' were used to identify relevant clinical studies of pharmacotherapy in patients with chronic venous disease (C4-C6). "
07/01/2019 - "It is important to recognize gemcitabine-related acute lipodermatosclerosis in order to avoid unnecessary antibiotic use and disruptions in chemotherapy."

03/01/2023 - "We aimed to clarify whether acute lipodermatosclerosis (LDS) progress to chronic LDS without continued compression therapy. "
03/25/2019 - "Compression Therapy Using Bandages Successfully Manages Acute or Subacute Lipodermatosclerosis."
04/01/1993 - "Treatment of lipodermatosclerosis consists of compression therapy with either graded stockings or elastic bandages. "
01/01/2006 - "This article presents a practice-oriented concept in the treatment of chronic venous ulcers with accompanying lipodermatosclerosis by shave therapy. "
01/01/2001 - "Evidence for the physiologic effect of compression therapy are decrease of edema, softening of lipodermatosclerosis, acceleration of venous flow, decrease in venous volume, blood shift into central compartments, reduction of venous refluxes, influence on arterial flow and improvement of microcirculation and lymph drainage. "

03/01/2006 - "Current techniques to treat venous ulcerations and patients with severe lipodermatosclerosis include the elimination of incompetent perforator veins by open surgical ligation and division or by subfascial endoscopic perforator surgery. "
07/01/1986 - "It is suggested that IPV ligation is the optimum treatment for venous ulceration and lipodermatosclerosis in patients who have only calf vein damage and that in most cases preoperative ascending venography is not necessary."
09/01/1996 - "The removal of the ulcer together with the extensive lipodermatosclerosis by Humby knife (shave-therapy) and immediate grafting with a meshed split skin graft-possibly in combination with ligation of insufficient perforator veins-yields very good success rates. "