Tufted angioma

A hereditary (autosomal dominant) type of hemangioma that occurs predominantly in children from birth through 5 years of age but may occur in adulthood. Some cases have also been reported in the mother during pregnancy. The lesions occur typically on the neck, shoulders, and trunk and appear histologically in a 'cannonball' distribution of rounded nodules or tufts of capillary-sized vessels in the dermis, with lymphatic vessels present at the periphery. Initial growth is slow and progressive, after which it tends to remain stable in size, although regression has been reported in some cases. Multiple tufted angioma may be associated with KASABACH-MERRITT SYNDROME. OMIM: 607859

Also Known As:

Networked: 54 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Kaposiform Hemangioendothelioma
2.	Kasabach-Merritt Syndrome
3.	Neoplasms (Cancer)
4.	Pain (Aches)
5.	Thrombocytopenia (Thrombopenia)

Experts

1.	Ji, Yi: 3 articles (05/2021 - 10/2019)
2.	Li, Kai: 3 articles (05/2021 - 08/2014)
3.	Wang, Zuopeng: 3 articles (05/2021 - 08/2014)
4.	Zheng, Shan: 3 articles (05/2021 - 08/2014)
5.	Yao, Wei: 2 articles (05/2021 - 10/2019)
6.	Dong, Kuiran: 2 articles (10/2019 - 08/2014)
7.	Gould, D: 2 articles (02/2008 - 04/2007)
8.	Parslew, R: 2 articles (02/2008 - 04/2007)
9.	Pizer, B: 2 articles (02/2008 - 04/2007)
10.	Gulliver, Jessica: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tufted angioma:

1.	SteroidsIBA 06/01/2017 - "In the present study, a 1-year-old pediatric patient with KMS arising from tufted angioma was successfully and variously treated with steroids, vincristine, surgery and propranolol for 18 months. " 02/01/2021 - "Case of tufted angioma treated successfully with tranilast, topical steroids and tacrolimus ointment."
2.	Sirolimus (Rapamycin)FDA Link 09/01/2018 - "We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. " 03/01/2018 - "Topical Rapamycin: An Additional Therapeutic Option for Tufted Angioma in Adults." 12/01/2017 - "Sirolimus therapy for children with problematic kaposiform haemangioendothelioma and tufted angioma." 09/01/2018 - "Sirolimus as first-line therapy shows great promise in the treatment of kaposiform hemangioendothelioma and tufted angioma." 09/01/2018 - "Sirolimus as initial therapy for kaposiform hemangioendothelioma and tufted angioma."
3.	Tacrolimus (Prograf)FDA LinkGeneric 11/01/2020 - "Topical tacrolimus reduces the severe pain of tufted angioma: Case report." 10/01/2019 - "Tacrolimus ointment for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma." 02/01/2021 - "Case of tufted angioma treated successfully with tranilast, topical steroids and tacrolimus ointment."
4.	Ointments (Pastes)IBA 10/01/2019 - "Tacrolimus ointment for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma." 02/01/2021 - "Case of tufted angioma treated successfully with tranilast, topical steroids and tacrolimus ointment."
5.	tranilastIBA 02/01/2021 - "Case of tufted angioma treated successfully with tranilast, topical steroids and tacrolimus ointment."
6.	Vincristine (Oncovin)FDA LinkGeneric 08/01/2010 - "Successful treatment of kaposiform hemangioendothelioma and tufted angioma with vincristine." 02/01/2008 - "Tufted angioma-associated Kasabach-Merritt syndrome treated with embolization and vincristine." 04/01/2007 - "Tufted angioma-associated Kasabach-Merritt syndrome treated with embolization and vincristine." 05/01/2021 - "Comparison of efficacy and safety of corticosteroid and vincristine in treating kaposiform hemangioendothelioma and tufted angioma: A multicenter prospective randomized controlled clinical trial." 10/01/2019 - " To evaluate the outcome and safety of corticosteroids and vincristine (VCR) in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). "
7.	Propranolol (Inderal)FDA LinkGeneric 12/01/2014 - "Successful treatment of tufted angioma with propranolol." 11/01/2012 - "We report 11 patients treated with propranolol for KHE and the related variant tufted angioma (TA), six of whom also had KMP. " 10/01/2020 - "We report a case of a large tufted angioma over the neck of a young girl, successfully treated with a combined approach of oral propranolol and foam sclerotherapy." 10/01/2020 - "Propranolol Followed by a Foam Sclerotherapy for Treatment of Tufted Angioma over Neck: A Novel Therapeutic Approach." 08/01/2014 - "Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon."
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/01/2010 - "We report a case of Kasabach-Merritt syndrome arising from a tufted angioma successfully treated with systemic corticosteroid. " 11/01/2010 - "Kasabach-merritt syndrome arising from tufted angioma successfully treated with systemic corticosteroid." 05/01/2021 - "Comparison of efficacy and safety of corticosteroid and vincristine in treating kaposiform hemangioendothelioma and tufted angioma: A multicenter prospective randomized controlled clinical trial." 10/01/2019 - " To evaluate the outcome and safety of corticosteroids and vincristine (VCR) in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). " 10/01/2019 - "Comparison of Corticosteroid and Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma: A Systematic Review and Meta-Analysis."
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 09/01/1997 - "Tufted angioma associated with platelet trapping syndrome: response to aspirin." 09/01/2013 - "This study aimed to clarify the combinatorial treatment effect of agents as aspirin and ticlopidine associated with vincristine in the management of Kasabach-Merritt phenomenon (KMP), a severe thrombocytopenic coagulopathy that occurs in the presence of an enlarging vascular tumor such as kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). "
10.	Ticlopidine (Ticlid)FDA LinkGeneric 09/01/2013 - "This study aimed to clarify the combinatorial treatment effect of agents as aspirin and ticlopidine associated with vincristine in the management of Kasabach-Merritt phenomenon (KMP), a severe thrombocytopenic coagulopathy that occurs in the presence of an enlarging vascular tumor such as kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). "

Therapies and Procedures

1.	Therapeutics 10/01/1998 - "This particular clinical presentation of tufted angioma should lead to wide and sufficiently deep biopsy to allow precise diagnosis prior to initiating therapy. " 01/01/1998 - "[Acquired tufted angioma in an adult: failure of pulsed dye laser therapy]." 08/01/1999 - "The more aggressive and rare vascular tumors, kaposiform hemangioendothelioma and tufted angioma, are often associated with thrombocytopenia and coagulopathy (Kasabach-Merritt phenomenon) and less responsive to pharmacological therapy. " 12/01/2017 - "Sirolimus therapy for children with problematic kaposiform haemangioendothelioma and tufted angioma." 09/01/2018 - "Sirolimus as first-line therapy shows great promise in the treatment of kaposiform hemangioendothelioma and tufted angioma."
2.	Dye Lasers 01/01/2023 - "Effectiveness of Pulsed Dye Laser Treatment in Tufted Angioma: A Promising Intervention." 11/01/2014 - "Late-onset tufted angioma with remarkable response to pulse dye laser." 10/01/2002 - "Response of childhood tufted angioma to the pulsed-dye laser." 01/01/1998 - "[Acquired tufted angioma in an adult: failure of pulsed dye laser therapy]." 10/01/2002 - "We report a case of tufted angioma in a child, which had a successful outcome after treatment with the pulsed-dye laser both in terms of cosmesis and alleviation of pain and discomfort."
3.	Sclerotherapy 01/01/2022 - "A retrospective study was conducted using medical records of all children with a diagnosis of kaposiform hemangioendothelioma (KHE) or tufted angioma (TA) associated with KMP treated with medicine, intralesional laser photocoagulation (ILP), and sclerotherapy between February 2017 and November 2020. " 10/01/2020 - "We report a case of a large tufted angioma over the neck of a young girl, successfully treated with a combined approach of oral propranolol and foam sclerotherapy." 10/01/2020 - "Propranolol Followed by a Foam Sclerotherapy for Treatment of Tufted Angioma over Neck: A Novel Therapeutic Approach."
4.	Aftercare (After-Treatment) 10/01/2002 - "We report a case of tufted angioma in a child, which had a successful outcome after treatment with the pulsed-dye laser both in terms of cosmesis and alleviation of pain and discomfort." 01/01/2007 - "We report an adult case of tufted angioma, with unusual presentation as annular plaques, which was alleviated after treatment with intense pulsed light in terms of both cosmetics and discomfort."
5.	Liver Transplantation 02/01/1992 - "An eruptive vascular proliferation resembling acquired tufted angioma in the recipient of a liver transplant."