Arrest of spermatogenesis

A hereditary autosomal dominant form of azoospermia characterized by infertility and testicular histology showing an arrest of spermatogenesis at the PACHYTENE STAGE of primary SPERMATOCYTES in males and recurrent spontaneous abortion occuring at 6 to 10 weeks of pregnancy in their female partners. Mutations in the SYCP3 gene have been identified. OMIM: 270960

Also Known As:

Networked: 86 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Atrophy
2.	Azoospermia
3.	Leigh Disease (Leigh's Disease)
4.	Mitochondrial encephalopathy
5.	Male Infertility (Male Sterility)

Experts

1.	Brehm, Ralph: 2 articles (02/2016 - 07/2007)
2.	Bergmann, Martin: 2 articles (01/2013 - 07/2007)
3.	Hassen, Ben Cheikh: 2 articles (05/2011 - 12/2009)
4.	Issam, Chargui: 2 articles (05/2011 - 12/2009)
5.	Monia, Zaouali: 2 articles (05/2011 - 12/2009)
6.	Zohra, Haouas: 2 articles (05/2011 - 12/2009)
7.	Bao, Meng: 1 article (01/2022)
8.	Cava, Claudia: 1 article (01/2022)
9.	Fan, Xiaorong: 1 article (01/2022)
10.	Huang, Jin: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arrest of spermatogenesis:

1.	EnzymesIBA 09/01/1995 - "With the hypothesis that a more marked decrease in alpha G activity occurs in OBS than in spermatogenesis arrest (SA), the enzyme was measured in the following groups: (1) vasectomized males (n = 15), (2) azoospermics with OBS (n = 7), (3) azoospermics with SA (n = 11), and (4) fertile males (n = 15). "
2.	Testosterone (Sustanon)FDA Link 05/01/2011 - "In conclusion the study shows that subcutaneous PRMT treatment causes an arrest of spermatogenesis, and a significant disharmony in testosterone concentration and MDA levels. " 07/01/2015 - "Inhibition of the HPG axis results in a fall in testosterone levels, which causes changes in Sertoli cells and the blood-testis barrier, leading to the arrest of spermatogenesis. " 12/24/1995 - "When radiofrequency current-lesioned hamsters were transferred from LD to SD they also failed to show significant signs of testicular regression, nor a decline in plasma testosterone concentrations, nor a complete arrest of spermatogenesis. " 09/01/1991 - "1) In July-August (winter in South America), a short hibernal period of sexual quiescence, decline in testicular and epididymal weights, arrest of spermatogenesis, and decrease of serum testosterone were observed. " 01/01/1985 - "We suggest that decreased intratesticular testosterone due to steroidogenic defect in the developing testis mainly contributes to the arrest of spermatogenesis."
3.	DNA (Deoxyribonucleic Acid)IBA 09/01/1996 - "DNA analysis by flow cytometry did not reveal any arrest of spermatogenesis, which was confirmed by histological studies. " 01/01/2007 - "Because MSY2 interacts with DNA and mRNAs, there are several distinct sites of action, which could be disrupted in mice that lack MSY2, resulting in the arrest of spermatogenesis. " 05/01/2018 - "Hence, it can be concluded that melatonin inhibits pre-meiotic spermatogenesis arrest in male germ cells through its anti-oxidative potential and ability to improve DNA reparative pathways, leading to normal sperm count and sperm morphology in RFR-exposed animals."
4.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/01/2012 - "In this study, isolated spermatogonial stem cells (SSCs) and Sertoli cells using enzymatic digestion from patients with maturation arrest of spermatogenesis were grown in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% foetal calf serum in three different groups: (1) SSCs cultured without Sertoli cells (2) SSCs co-cultured with Sertoli cells (as control group), (3) SSCs co-cultured with Sertoli cells and adding different concentrations of basic fibroblast growth factor (0.1, 1, 10 ng ml(-1)) and human leukaemia inhibitory factor (1000, 1200, 1500 unit ml(-1)) as experimental groups. "
5.	Gonadal Steroid Hormones (Sex Hormones)IBA 12/01/2009 - "In conclusion the study shows that subcutaneous DM treatment produces an arrest of spermatogenesis, a significant disharmony in sex hormones and MDA levels in rats that is related to dose, length of treatment and to the lipid peroxidation which may be one of the molecular mechanisms involved in DM-induced gonads toxicity."
6.	Peptide Hydrolases (Proteases)FDA Link 01/01/2023 - "In this study, we demonstrate that mice deficient for the mitochondrial intra-membrane rhomboid protease PARL, a recently reported model of the mitochondrial encephalopathy Leigh syndrome, develop early testicular atrophy caused by a complete arrest of spermatogenesis during meiotic prophase I, followed by degeneration and death of arrested spermatocytes. "
7.	Carnitine (L-Carnitine)FDA LinkGeneric 01/01/1988 - "This study allows (1) to define the diagnosis value of the seminal carnitine assay, which remains the only test to affirm excretory azoospermia when there is a bilateral occlusion located on the genital tract between the epididymis corpus and the ejaculatory ducts, (2) to consider another treatment than epididymo-vasostomy in cases of occlusion caput--corpus (epididymo-epididymostomy), (3) to detect a population presenting a very early arrest of spermatogenesis without any pituitary effect, probably having a special regulation of FSH secretion."
8.	Messenger RNA (mRNA)IBA 11/27/2006 - "Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice." 01/01/2013 - "All of these showed significantly lower or even absent mRNA expression in severe disorders of spermatogenesis (arrest at the level of spermatocytes or spermatogonia, Sertoli cell only syndrome). " 01/01/2022 - "Further, CIRBP was shown to bind directly to the 3'-untranslated region of Ccnb1 mRNA and was associated with cyclin B1-induced inhibition of spermatogenesis arrest. " 02/01/1991 - "Transient arrest of spermatogenesis in two-month-old rats after injection of a single dose of busulphan (10 mg/kg) resulted in parallel but transient decrease in the 1.4 kb of beta-pol mRNA level to an undetectable value, followed by its reappearance after resumption of spermatogenesis. " 01/01/2022 - "Rs550967205 (A > G) positioned at 3' UTR CRISP2 and rs544604911 (T > C) located at 3' UTR PLK1, with lowest MFE in miRNA-mRNA interaction, were assumed to have possible pathogenic roles linked to spermatogenesis arrest. "
9.	Proteins (Proteins, Gene)FDA Link 05/01/1990 - "The present results support our previous observation that immunization of male rabbits with the rSMP-B protein results in the arrest of spermatogenesis at the spermatid stage. " 03/01/2002 - "It is, therefore, suggested for the first time that P16(INK4a) protein may inhibit the spermatogonia mitosis in the testis at the later stage of the germ cell apoptosis, resulting in arrest of spermatogenesis." 03/01/1990 - "Histologically, in the testis of animals of group IV (protein deficient + gossypol) almost all the tubules were disorganised and vacuolated and total arrest of spermatogenesis could be observed in majority of the tubules." 03/01/2021 - "Immunoblot analysis showed that total testicular protein O-linked β-N-acetylglucosamine glycosylation was related to spermatogenesis arrest, further indicating a decrease in UDP-GlcNAc in the cryptorchid group. " 07/01/1999 - "Reduced testicular and accessory organ protein, sialic acid and vesicular fructose content manifested arrest of spermatogenesis and depletion of androgen level."
10.	Busulfan (Busulfex)FDA Link 02/01/1989 - "Transient arrest of spermatogenesis in rats aged 2 months following injection of a single dose of busulphan (10 mg/kg) resulted in a parallel but transient decrease in the transcript level to undetectable values, followed by its reappearance after resumption of spermatogenesis. " 01/01/2007 - "In general, busulfan caused a decrease in all analyzed parameters (except capsule thickness, normal tubules without sperm and abnormal tubules), probably due to the arrest of spermatogenesis. " 02/01/1991 - "Transient arrest of spermatogenesis in two-month-old rats after injection of a single dose of busulphan (10 mg/kg) resulted in parallel but transient decrease in the 1.4 kb of beta-pol mRNA level to an undetectable value, followed by its reappearance after resumption of spermatogenesis. " 01/01/2007 - "We injected the androgen antagonists, flutamide and vinclozolin, directly into seminiferous tubules of live mice, which had been treated with busulfan for a temporal arrest of spermatogenesis, and the testes were histologically examined to see the effect of the injected materials on spermatogenesis that was in the process of recovery. "

Therapies and Procedures

1.	Vasovasostomy (Vasectomy Reversal) 01/01/1988 - "This study allows (1) to define the diagnosis value of the seminal carnitine assay, which remains the only test to affirm excretory azoospermia when there is a bilateral occlusion located on the genital tract between the epididymis corpus and the ejaculatory ducts, (2) to consider another treatment than epididymo-vasostomy in cases of occlusion caput--corpus (epididymo-epididymostomy), (3) to detect a population presenting a very early arrest of spermatogenesis without any pituitary effect, probably having a special regulation of FSH secretion."
2.	Orchiopexy 08/01/2019 - "(3) Exposure to DBP or AA with CPT/orchiopexy led to atrophic testes, spermatogenesis arrest, germ cell exfoliation/multinucleation, and SCO tubules (both chemicals score 2.5). " 08/01/2019 - "(2) CPT (score 3.3) resulted in decreased absolute testes weights, degenerated and SCO tubules, and spermatogenesis arrest that were reversed by orchiopexy (score 1.1). "
3.	Low-Level Light Therapy (LLLT) 04/27/2023 - "Photobiomodulation therapy reverses spermatogenesis arrest in hyperthermia-induced azoospermia mouse model."
4.	Heterologous Transplantation (Xenotransplantation) 01/01/2021 - "Although testis xenografting has been extensively tested and attained great achievement in other species, the prepubertal rat testicular tissue xenografting to immunodeficient mice exhibited obvious spermatogenesis arrest and oxidative damage. "
5.	Induced Hyperthermia (Thermotherapy) 04/27/2023 - "Photobiomodulation therapy reverses spermatogenesis arrest in hyperthermia-induced azoospermia mouse model."