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Familial renal cell carcinoma

Also Known As:

Familial renal carcinoma

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Site: 4
  - Urogenital Neoplasms: 471
    - Urologic Neoplasms: 880
      - Kidney Neoplasms: 6284
        Renal Cell Carcinoma: 28755
        Familial renal cell carcinoma: 5
- Neoplasms by Histologic Type: 2
  - Glandular and Epithelial Neoplasms: 439
    - Carcinoma: 141855
      - Adenocarcinoma: 58365
        Renal Cell Carcinoma: 28755
        Familial renal cell carcinoma: 5
Urogenital Diseases: 126

Related Diseases

1.	Carcinogenesis
2.	Neoplasms (Cancer)

Experts

1.	Ball, Mark W: 1 article (01/2021)
2.	Lang, Martin: 1 article (01/2021)
3.	Linehan, William M: 1 article (01/2021)
4.	Metwalli, Adam R: 1 article (01/2021)
5.	Ricketts, Christopher J: 1 article (01/2021)
6.	Schmidt, Laura S: 1 article (01/2021)
7.	Vocke, Cathy D: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial renal cell carcinoma:

1.	DNA (Deoxyribonucleic Acid)IBA 02/01/1994 - "To investigate the role of tumour-suppressor genes on the short arm of chromosome 3 in the mechanism of tumorigenesis in non-familial renal cell carcinoma, we analysed 55 paired blood-tumour DNA samples for allele loss on chromosome 3p and in the region of known or putative tumour-suppressor genes on chromosomes 5, 11, 17 and 22. " 03/15/1997 - "The FHIT gene spans approximately 1 Mb of DNA at chromosome band 3p14.2, which includes the familial renal cell carcinoma chromosome translocation breakpoint (between FHIT exons 3 and 4), the most frequently expressed human constitutive chromosomal fragile site (FRA3B, telomeric to the t(3;8) translocation), and numerous homozygous deletions in various human cancers, frequently involving FHIT exon 5. The FRA3B has previously been shown to represent more than one specific site, and some specific representatives of FRA3B breaks have been shown to fall in two regions, which we know to be in FHIT introns 4 and intron 5. Because breakage and integration of exogenous DNA in this chromosome region is frequent in aphidicolin-treated somatic cell hybrids, cancer cells, and, presumably, aphidicolin-treated normal lymphocytes that exhibit gaps or breaks, we determined by one- and two color fluorescence in situ hybridization, using cosmids covering specific regions of the FHIT gene, that most of the aphidicolin-induced gaps at FRA3B fall within the FHIT gene, with the highest frequency of gaps falling in intron 5 of the FHIT gene, less than 30 kb telomeric to FHIT exon 5. Gaps also occur in intron 4, where a human papillomavirus 16 integration site has been localized, and in intron 3, where the t(3;8) break point is located. "
2.	Class 5 Receptor-Like Protein Tyrosine PhosphatasesIBA 03/01/1996 - "The receptor protein tyrosine phosphatase gamma gene, PTP gamma (locus name PTPRG), was previously mapped to chromosome region 3p14.2, within a 2- to 4-Mb region centromeric to the 3p14.2 breakpoint of the t(3;8) familial renal cell carcinoma (RCC)-associated constitutional chromosome translocation. "
3.	Microphthalmia-Associated Transcription FactorIBA 01/01/2021 - "To characterize the clinical presentation, genomic alterations, pathologic phenotype and clinical management of microphthalmia-associated transcription factor (MITF) familial renal cell carcinoma (RCC), caused by a member of the TFE3, TFEB, and MITF family of transcription factor genes. "
4.	AphidicolinIBA 03/15/1997 - "The FHIT gene spans approximately 1 Mb of DNA at chromosome band 3p14.2, which includes the familial renal cell carcinoma chromosome translocation breakpoint (between FHIT exons 3 and 4), the most frequently expressed human constitutive chromosomal fragile site (FRA3B, telomeric to the t(3;8) translocation), and numerous homozygous deletions in various human cancers, frequently involving FHIT exon 5. The FRA3B has previously been shown to represent more than one specific site, and some specific representatives of FRA3B breaks have been shown to fall in two regions, which we know to be in FHIT introns 4 and intron 5. Because breakage and integration of exogenous DNA in this chromosome region is frequent in aphidicolin-treated somatic cell hybrids, cancer cells, and, presumably, aphidicolin-treated normal lymphocytes that exhibit gaps or breaks, we determined by one- and two color fluorescence in situ hybridization, using cosmids covering specific regions of the FHIT gene, that most of the aphidicolin-induced gaps at FRA3B fall within the FHIT gene, with the highest frequency of gaps falling in intron 5 of the FHIT gene, less than 30 kb telomeric to FHIT exon 5. Gaps also occur in intron 4, where a human papillomavirus 16 integration site has been localized, and in intron 3, where the t(3;8) break point is located. "
5.	Transcription Factors (Transcription Factor)IBA 01/01/2021 - "To characterize the clinical presentation, genomic alterations, pathologic phenotype and clinical management of microphthalmia-associated transcription factor (MITF) familial renal cell carcinoma (RCC), caused by a member of the TFE3, TFEB, and MITF family of transcription factor genes. "
6.	Histidine (L-Histidine)FDA Link 09/01/1997 - "The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. "