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T-Lymphocytopenia

Networked: 45 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Cytopenia: 2582
    - Leukopenia: 5826
      - Lymphopenia: 4691
        T-Lymphocytopenia: 45
  - Leukocyte Disorders: 8
    - Leukopenia: 5826
      - Lymphopenia: 4691
        T-Lymphocytopenia: 45
Immune System Diseases: 4321
- Immunologic Deficiency Syndromes: 91
  - Lymphopenia: 4691
    - T-Lymphocytopenia: 45

Related Diseases

1.	Lymphocytosis
2.	Sepsis (Septicemia)
3.	Disease Progression
4.	Neutropenia
5.	Delayed Hypersensitivity (Hypersensitivity, Type IV)

Experts

1.	Gandhi, Varsha: 2 articles (10/2006 - 12/2005)
2.	Chen, Peng-Chieh: 1 article (12/2020)
3.	Chiu, Frank Po-Chao: 1 article (12/2020)
4.	Hsu, Chao-Kai: 1 article (12/2020)
5.	Huang, Hsin-Yu: 1 article (12/2020)
6.	Huang, Yi-Ting: 1 article (12/2020)
7.	Kosumi, Hideyuki: 1 article (12/2020)
8.	Miyauchi, Toshinari: 1 article (12/2020)
9.	Natsuga, Ken: 1 article (12/2020)
10.	Nomura, Toshifumi: 1 article (12/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to T-Lymphocytopenia:

1.	AutoantibodiesIBA 01/01/2023 - "Experimental studies confirmed the predictions of the computer model and showed that neonatal immunization with gp120 suppresses anti-CD4 autoantibody production and prevents the development of autoimmune CD4 T lymphocytopenia triggered in adult rats by gp120. " 03/01/1992 - "T-lymphocytopenia was accompanied by a dysbalance of the main correlative cells according to a relatively hyposuppressor variant of immune deficit with formation of circulating immune complexes and thermodependent lymphocytotoxic autoantibodies."
2.	Cytotoxins (Cytolysins)IBA 10/01/1991 - "A more severe clinical course (repeated pyo-inflammatory diseases, sepsis) was recorded in infants with alloimmune neutropenia caused by granulo-cytotoxins, alloimmune neutropenia was characterized by disorders in neutrophil phagocytic activity (mainly, due to decreased digestive capacity of cells), inhibition of colony-forming capacity of precursor-cells of granulocytopoiesis; a tendency to T-lymphocytopenia was noted during the study of cellular immunity parameters. "
3.	AntigensIBA 03/01/1984 - "The revealed T lymphocytopenia and decrease in the fraction of the immunoregulating cells are, on the one hand, the cause of the frequent inflammatory complications and, on the other, conducive to the development of autosensitization of the organism to the brain antigens, which was confirmed in study of the specific features of delayed hypersensitivity."
4.	Immunoglobulin G (IgG)IBA 01/01/2017 - "Laboratory data showed T-lymphocytopenia (492/µl), increased serum IgG levels (1,984 mg/dl), and low serum antibody titers for specific pathogens. " 08/05/1997 - "The patient had a combined acquired immunodeficiency syndrome (AIDS) which included CD4+ and CD8+ T-lymphocytopenia, monocytopenia and a deficiency in the IgG subclasses 2 and 4. HIV testing was repeatedly negative. " 01/01/1990 - "In patients, T-lymphocytopenia, impaired ratio of subpopulations of the helpers and suppressors, increase in the absorptive and metabolic activity of neutrophilic granulocytes, lysozyme activity of the blood serum, decrease in the immunoglobulin G content are observed." 11/01/1991 - "282 patients subjected to radiation effects showed a marked and persistent T-lymphocytopenia, B-lymphocytosis, reduction of the content of T-helpers, T-suppressors, dysimmunoglobulinemia characterized by reduction of IgG content and excessive IgA secretion. "
5.	DNA (Deoxyribonucleic Acid)IBA 03/01/2000 - "In the infected Japanese macaques, peripheral CD4(+) and CD8(+) T-cell populations were markedly decreased and fragmentation of chromosomal DNA in peripheral blood mononuclear cells was detected during the terminal period of infection, suggesting that apoptotic cell death was responsible at least in part for the T lymphocytopenia. " 07/01/2012 - "A 10-year-old Japanese boy developed acute hepatitis with high levels of serum Torque teno virus DNA and marked lymphocytopenia, especially CD4 T-lymphocytopenia. " 11/01/2012 - "Copy number of the junctional portion of the δRec-ψJα TREC, assessed by quantitative PCR (qPCR) using DNA from dried blood spots (DBS), is a biomarker for newly formed T cells and absent or low numbers of TRECs indicate SCID (severe combined immunodeficiency) or T lymphocytopenia. "
6.	ChemokinesIBA 08/23/2001 - "DOCK2-deficient mice (DOCK2-/-) exhibited migration defects of T and B lymphocytes, but not of monocytes, in response to chemokines, resulting in several abnormalities including T lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. " 10/01/2011 - "T cell chemotaxis to sphingosine 1-phosphate (S1P) and the chemokines CCL21 and CCL5 was studied in ten adults with T lymphocytopenia, other immunological abnormalities (nine of ten), and frequent bacterial infections (seven of ten). "
7.	Purine-Nucleoside PhosphorylaseIBA 10/01/2006 - "Purine nucleoside phosphorylase (PNP) deficiency in humans results in T lymphocytopenia. " 12/15/2005 - "The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme could serve as a therapeutic target. "
8.	Prednisolone (Predate)FDA LinkGeneric 01/01/1984 - "Prednisolone induces a T lymphocytopenia in the peripheral blood that affects OKT4-positive lymphocytes more than OKT8-positive lymphocytes, resulting in a slight decrease in the ratio OKT4/OKT8. " 10/01/1983 - "Thus, in comparison with patients with primary CMV infection not treated with Prednisolone bolus, those with primary CMV infection and parallel treatment with a Prednisolone bolus had a higher rate of T-lymphocytopenia and a significantly delayed humoral immune response to CMV. "
9.	Interleukin-2 (IL2)IBA 05/01/1999 - "Treatment of idiopathic CD4 T lymphocytopenia with IL-2." 07/01/2008 - "Interleukin-2 treatment for persistent cryptococcal meningitis in a child with idiopathic CD4(+) T lymphocytopenia."
10.	Immunoglobulins (Immunoglobulin)IBA 02/08/1997 - "Idiopathic CD4(+)-T lymphocytopenia is a heterogeneous pathological condition with normal serum immunoglobulin concentrations. " 02/11/1993 - "Concomitant CD8+ T-lymphocytopenia was noted in three patients, and abnormal immunoglobulin levels were found in five. "

Therapies and Procedures

1.	Radiotherapy 10/01/1976 - "Although a group of 26 patients in continuous complete remission from 12 to 111 mo after radiation treatment regained normal total numbers of lymphocytes and monocytes, they exhibited a striking T lymphocytopenia and B lymphocytosis. " 09/01/1975 - "The results therefore indicate that the number of B lymphocytes is more rapidly normalized after radiotherapy than that of T lymphocytes, and that the post-irradiation lymphocytopenia is mainly a T lymphocytopenia. " 11/01/1997 - "T-lymphocytopenia and dysfunction, monocyte dysfunction, prostaglandins, antigen-antibody complexes, serum and cell suppressive factors, radiation therapy and poor nutrition with zinc deficiency all contribute. "
2.	Transplantation 01/01/1990 - "Our neonatal thymus transplantation studies and the adult thymus transplantation studies of others suggest a third defect in the BB rat, within the thymus itself, but this defect appears not to be responsible for the development of either the diabetes or the T lymphocytopenia. "
3.	Therapeutics 10/01/2007 - "Idiopathic CD4(+) T lymphocytopenia (ICL) is defined as a CD4(+) T-cell count <0.3 x 10(9)/l or <20% of the total T-cell count on two occasions in the absence of any immunodeficiency disorder or therapy associated with reduced CD4(+) T-cell count. " 08/01/1983 - "After therapy, all patients exhibited a profound T lymphocytopenia, and a reversal in their T suppressor/cytotoxic cell to helper cell ratio. " 07/01/2008 - "This case is the first reported pediatric idiopathic CD4(+) T-lymphocytopenia case with cryptococcal meningitis that was successfully treated by the addition of rIL-2 therapy to antifungal therapy." 04/01/1998 - "The presence of a positive DAT prior to therapy in 3 of 4 patients developing haemolysis suggests that the CDA induced T-lymphocytopenia may exacerbate the tendency of certain CLL patients to autoimmune haemolysis."
4.	Neonatal Intensive Care 07/10/2023 - "Severe congenital T-lymphocytopenia may affect the outcome of neonatal intensive care."