Alveolar echinococcosis

Helminth infection caused by ECHINOCOCCUS MULTILOCULARIS that forms parasitic tumors in the liver (ECHINOCOCCOSIS, HEPATIC) primarily but also in the lungs, brain, and other organs.

Also Known As:

Networked: 505 relevant articles (41 outcomes, 50 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Liver Cirrhosis (Hepatic Cirrhosis)
2.	Infections
3.	Inflammation (Inflammations)
4.	Fistula
5.	Echinococcosis (Hydatid Cysts)

Experts

1.	Kern, Peter: 23 articles (02/2022 - 02/2003)
2.	Gottstein, Bruno: 21 articles (01/2022 - 02/2002)
3.	Ito, Akira: 17 articles (01/2014 - 08/2002)
4.	Hemphill, Andrew: 16 articles (10/2021 - 04/2004)
5.	Wen, Hao: 16 articles (01/2020 - 12/2004)
6.	Sako, Yasuhito: 15 articles (01/2014 - 08/2002)
7.	Grüner, Beate: 14 articles (03/2022 - 08/2008)
8.	Bresson-Hadni, Solange: 14 articles (01/2022 - 11/2002)
9.	Wang, Junhua: 11 articles (01/2022 - 01/2014)
10.	Brehm, Klaus: 11 articles (11/2020 - 02/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alveolar echinococcosis:

1.	Albendazole (Albenza)FDA Link 09/01/1998 - "Cutaneous parasitic lesions, associated with a dense fibrous reaction, markedly improved under albendazole treatment in one case of supraumbilical skin localization of alveolar echinococcosis. " 08/30/2022 - "In order to increase the understanding of the therapeutic efficacy of albendazole for alveolar echinococcosis, this review summarizes the advances in albendazole treatment for alveolar echinococcosis, so as to provide insights into the clinical treatment of alveolar echinococcosis with albendazole. " 12/01/1992 - "Evidently albendazole was effective in the treatment of alveolar echinococcosis." 11/01/1991 - "Evidently, albendazole is effective in the treatment of alveolar hydatid disease. " 10/01/2021 - "Clinical tolerance and efficacy of anti-parasitic treatment with albendazole in patients with alveolar echinococcosis: long-term follow-up observation in 117 patients."
2.	AntigensIBA 06/01/2007 - "Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen." 05/01/1995 - "Our in vitro restimulation studies with crude Echinococcus multilocularis antigen demonstrated that PBMC from patients with alveolar echinococcosis were responsive to challenge with parasitic antigen as measured by lymphoid cell proliferation. " 09/01/2022 - "Laboratory diagnosis including antibody-antigen (recombinant or fusion recombinant) can be used for the diagnosis and follow up of CE and alveolar echinococcosis (AE), but need optimization and standardization. " 11/01/2020 - "Samples belong to a retrospective cohort of 253 well-characterized patients with CE, previously described for the evaluation of the 2B2t antigen, 92 patients with alveolar echinococcosis, and 82 healthy donors. " 01/01/2018 - "The lowest cross-reactivity with sera from patients with alveolar echinococcosis was detected with the recombinant antigens in ELISA (9.5% - 16.7%) and the highest with the HF-IC (64.3%). "
3.	EnzymesIBA 02/01/2016 - "To study the effect of Echinococcus multilocularis infection on the activities of drug-metabolizing enzymes in gerbil liver. " 02/01/2016 - "[Effect of Echinococcus multilocularis Infection on the Activities of Drug-metabolizing Enzymes in Gerbil Liver]." 08/01/2022 - "In order to further elucidate this process and promote the development in treatment of echinococcosis, we investigated the effects of Echinococcus multilocularis infection and drug treatment on biotransformation enzymes in mouse liver. " 01/01/1997 - "An improved enzyme-linked immunosorbent assay (ELISA) system using partially purified Eml8/16 enriched fraction (PP-Em18/16) prepared by isoelectric focusing was evaluated for serodiagnosis of alveolar echinococcosis (AE). " 07/01/1986 - "Therefore, we improved on the procedure of the enzyme-linked immunosorbent assay (micro-ELISA) for serological diagnosis of multilocular echinococcosis to carry out the epidemiological survey. "
4.	ImmunosorbentsIBA 01/01/1997 - "An improved enzyme-linked immunosorbent assay (ELISA) system using partially purified Eml8/16 enriched fraction (PP-Em18/16) prepared by isoelectric focusing was evaluated for serodiagnosis of alveolar echinococcosis (AE). " 07/01/1986 - "Therefore, we improved on the procedure of the enzyme-linked immunosorbent assay (micro-ELISA) for serological diagnosis of multilocular echinococcosis to carry out the epidemiological survey. " 10/01/2018 - "The present study purified the recombinant Em18-GST (rEm18-GST), and detected its diagnostic performance in human alveolar echinococcosis patients of Xinjiang, China with immunoblotting (IB) and enzyme-linked immunosorbent assay (ELISA). " 01/01/2006 - "Today a highly sensitive enzyme-linked immunosorbent assay as well as a highly specific westernblot system are available for the serological diagnosis of human alveolar echinococcosis cases, for the serological monitoring of the disease as well as for seroepidemiological and preventive medical studies. " 11/01/2002 - "Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test."
5.	CytokinesIBA 09/01/2000 - "To clarify the role of Th1- and Th2-type cytokines in the various outcomes of human alveolar echinococcosis (AE), the cytokine immune response of self-cured patients was studied and compared with those of progressive AE patients and healthy subjects. " 06/15/2020 - "The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis." 12/15/2004 - "to approach the relationship between alveolar echinococcosis (AE) pathology and level of sIL-2R,TNF-alpha and IFN-gamma in sera and the significance of cytokines in development of AE. After 23 patients with AE were confirmed by ELISA and ultrasound, their sera were collected and the concentrations of sIL-2R,TNF-alpha and IFN-gamma were detected by double antibody sandwich. " 12/01/2004 - "[Change of cytokines in mice with Echinococcus multilocularis infection]." 09/01/2000 - "Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile in humans. "
6.	Mebendazole (Anti-Worm)FDA Link 07/01/1994 - "The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. " 03/01/1993 - "[The mebendazole treatment of patients with alveolar echinococcosis]." 09/01/1985 - "Thirty-three patients with alveolar echinococcosis treated by surgery or with mebendazole were observed up to six years. " 01/01/1985 - "These data are the first controlled evidence that high oral doses of mebendazole may be parasitostatic in alveolar echinococcosis in man. " 09/01/1984 - "Medical treatment with mebendazole was introduced in 1977 for cystic and alveolar Hydatid disease of the liver. "
7.	ChemokinesIBA 08/01/2008 - "Echinococcus multilocularis: inflammatory and regulatory chemokine responses in patients with progressive, stable and cured alveolar echinococcosis." 08/01/2006 - "Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients." 02/01/2022 - "Echinococcus multilocularis specific antibody, systemic cytokine, and chemokine levels, as well as antigen-specific cellular responses in patients with progressive, stable, and cured alveolar echinococcosis: A 10-year follow-up."
8.	ChitosanIBA 10/01/2015 - "Correction: Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice." 01/01/2015 - "Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice."
9.	Proteins (Proteins, Gene)FDA Link 02/22/2022 - "[Preliminary study on differentially expressed proteins in a mouse model of secondary alveolar echinococcosis based on data independent acquisition proteomics]." 10/01/2011 - "In the present study, we have identified and characterized a novel member of this protein family, EmSmadE, in the human parasitic cestode Echinococcus multilocularis, the causative agent of alveolar echinococcosis. " 02/22/2022 - "A large number of differentially expressed proteins are identified in the liver of the mouse model of alveolar echinococcosis, and Fabp1, Acsl1, Acox1, Ehhadh and Acaa1b may contribute to the pathogenesis of alveolar echinococcosis. " 02/01/2022 - "Echinococcus granulosus Protoscolex DM9 Protein Shows High Potential for Serodiagnosis of Alveolar Echinococcosis." 01/01/2017 - "The repertoires of identified proteins also provided potential molecular markers for important biological features, such as parasite growth rate and fertility, as well potential protein targets for the development of novel diagnostic and treatment strategies for alveolar echinococcosis. "
10.	benzimidazoleIBA 07/01/1994 - "[Efficacy of benzimidazole-type drugs on alveolar echinococcosis (AE)]." 06/01/2010 - "The present study aimed to identify a sub-group of inoperable alveolar echinococcosis (AE) patients undergoing long-term treatment with benzimidazole (BZM) who presented with an evolution suggestive of a parasitocidal effect. " 01/01/2015 - "Outcome after Discontinuing Long-Term Benzimidazole Treatment in 11 Patients with Non-resectable Alveolar Echinococcosis with Negative FDG-PET/CT and Anti-EmII/3-10 Serology." 01/02/2013 - "This patient had no immune suppression, and did not have the genetic background known to predispose to severe alveolar echinococcosis; it may thus be hypothesized that iterative multi-organ involvement was mostly due to the poor adherence to benzimidazole treatment for the first decade after diagnosis. " 11/01/2003 - "Long-term benzimidazole treatment of alveolar echinococcosis with hematogenic subcutaneous and bone dissemination."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/1998 - "Surgical removal of macroscopically detectable metacestode tissue followed by postoperative chemotherapy according to established human protocols resulted in complete clinical remission and immediate normalization of hyperglobulinemia in a dog with alveolar echinococcosis (AE). " 03/01/1994 - "The efficacy of long-term chemotherapy in nonresectable alveolar echinococcosis is debated, particularly because of the difficulty in defining therapeutic success. " 06/01/2013 - "The aim of this study was to investigate the clinical efficiency of chemotherapy for the treatment of human alveolar echinococcosis (AE). " 10/01/2004 - "Immunosurveillance of alveolar echinococcosis by specific humoral and cellular immune tests: long-term analysis of the Swiss chemotherapy trial (1976-2001)." 02/27/1999 - "[Swiss study of chemotherapy of alveolar echinococcosis--review of a 20-year clinical research project]."
2.	Therapeutics 06/01/1997 - "The efficacy of medical therapy and its relationship to the role of surgical intervention in the management of unilocular (cystic) and multilocular (alveolar) hydatid disease is discussed. " 01/01/2022 - "The aim of our study was to determine the role 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in staging of patients with alveolar echinococcosis and to identify quantitative imaging parameters related to patient outcome and/or duration of benzimidazole therapy. " 03/12/2022 - "Recent improvements in alveolar echinococcosis (AE) therapy can provide long-term disease control, and even allow structured treatment interruption in selected cases. " 01/01/2022 - "To investigate the potential role of follow-up 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in therapy control of inoperable patients with alveolar echinococcosis. " 08/01/2018 - "Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis."
3.	Microspheres (Microsphere) 01/01/2020 - "In vivo effect of magnetic microspheres loaded with E2-a in the treatment of alveolar echinococcosis." 01/01/2020 - "It will be an alternative treatment for alveolar echinococcosis using magnetic microspheres as drug carriers." 10/01/2015 - "Correction: Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice." 01/01/2015 - "Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice."
4.	Liver Transplantation 09/01/1996 - "We report the case of a 29-year-old female who is disease-free more than six years after liver transplantation for a recurrent alveolar echinococcosis of the liver, confirming the place for liver transplantation in this disorder." 08/01/2020 - "This study focused on the monitoring of patients who had undergone liver transplantation (LT) because of unresectable alveolar echinococcosis (AE). " 01/01/2016 - "The aim of this study was to evaluate the clinical value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in advanced liver alveolar echinococcosis (LAE) prior to and following autologous liver transplantation (ALT). " 10/01/2023 - "Lung and brain recurrence after liver transplantation for advanced alveolar echinococcosis: A case report." 01/03/2023 - "After liver transplantation, alveolar echinococcosis was diagnosed in the liver explant."
5.	Hepatectomy 05/01/2011 - "Hepatectomy is the first-line treatment for alveolar echinococcosis (AE) if complete resection is feasible. " 08/01/2017 - "In this study, we therefore retrospectively reviewed and evaluated the safety and feasibility of two-stage hepatectomy in patients with multiple giant alveolar echinococcosis.We" 01/01/2022 - "Extended left hepatectomy with inferior vena cava reconstruction and veno-venous bypass for alveolar echinococcosis (with video)." 08/01/2017 - "-stage hepatectomy is safe and feasible for patients with multiple giant alveolar echinococcosis." 08/01/2017 - " reviewed the data for all patients who underwent 2-stage hepatectomy for multiple giant alveolar echinococcosis between August 2013 and December 2015 at either the West China Hospital of Sichuan University or the Hospital of Ganzi Tibetan Autonomous Prefecture.We"