Primary orthostatic tremor

Rapid tremor of the legs that occurs while standing and is relieved by walking or sitting. Affected individuals often feel unsteady or imbalanced and will avoid standing still due to fear of falling.

Also Known As:

Networked: 18 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Primary orthostatic tremor
2.	Tremor (Tremors)
3.	Parkinson Disease (Parkinson's Disease)
4.	Hydrocephalus (Hydrocephaly)

Experts

1.	Gironell, Alexandre: 2 articles (01/2019 - 01/2018)
2.	Byrnes, Michelle L: 2 articles (07/2006 - 07/2005)
3.	Edwards, Dylan J: 2 articles (07/2006 - 07/2005)
4.	Mastaglia, Frank L: 2 articles (07/2006 - 07/2005)
5.	Rodrigues, Julian P: 2 articles (07/2006 - 07/2005)
6.	Stell, Rick: 2 articles (07/2006 - 07/2005)
7.	Walters, Susan E: 2 articles (07/2006 - 07/2005)
8.	Li, Wei: 1 article (01/2022)
9.	Liu, Yiming: 1 article (01/2022)
10.	Lv, Hongbo: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary orthostatic tremor:

1.	Botulinum Toxins (Botulinum Toxin)IBA 11/01/2013 - "Safety and efficacy of botulinum toxin in primary orthostatic tremor."
2.	Pramipexole (Mirapex)FDA LinkGeneric 10/01/2000 - "Pramipexole is a potential therapy for primary orthostatic tremor. " 10/01/2000 - "Pramipexole is a possible effective treatment for primary orthostatic tremor (shaky leg syndrome)."
3.	Levodopa (L Dopa)FDA LinkGeneric 05/01/1999 - "On the basis of this finding eight patients with primary orthostatic tremor were treated with levodopa. " 05/01/1999 - "This study is the first trial of therapy in primary orthostatic tremor and suggests that levodopa can lead to good symptomatic relief in this potentially disabling condition." 11/01/2001 - "We describe three cases of fast orthostatic tremor (FoT) of legs and trunk mimicking primary orthostatic tremor (OT) in patients treated with levodopa for PD. " 05/01/1999 - "The patient exhibited the classic features of primary orthostatic tremor with relief of the tremor by walking or sitting while treated with levodopa. " 05/01/1999 - "A patient with primary orthostatic tremor who 9 years later developed levodopa responsive idiopathic Parkinson's disease is described. "
4.	perampanelIBA 01/01/2020 - "Remarkable improvement of primary orthostatic tremor using perampanel." 01/01/2019 - "Primary Orthostatic Tremor: Experience of Perampanel Use in 20 Patients." 01/01/2019 - "Successful Treatment of Primary Orthostatic Tremor Using Perampanel." 01/01/2018 - "Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel."
5.	Gabapentin (Neurontin)FDA LinkGeneric 07/01/2006 - "Blinded placebo crossover study of gabapentin in primary orthostatic tremor." 07/01/2005 - "Gabapentin can improve postural stability and quality of life in primary orthostatic tremor."
6.	Immunoglobulins (Immunoglobulin)IBA 08/01/2005 - "Is primary orthostatic tremor associated with an autochthonous immunoglobulin synthesis in the cerebrospinal fluid?"
7.	Immunoglobulin G (IgG)IBA 03/01/2003 - "We describe the first patient with a typical phenotype of primary orthostatic tremor who has a persistent isolated monoclonal immunoglobulin G band in the cerebrospinal fluid." 03/01/2003 - "Primary orthostatic tremor associated with a persistent cerebrospinal fluid monoclonal IgG band."
8.	Levetiracetam (Keppra)FDA LinkGeneric 11/01/2011 - "Levetiracetam in primary orthostatic tremor: a double-blind placebo-controlled crossover study."
9.	AS 8IBA 09/15/2008 - "Longstanding primary orthostatic tremor is not necessarily associated with (123)I-FP-CIT SPECT abnormalities, as 8 of our patients had more than a 10-year history of OT. "
10.	N 30IBA 07/01/2014 - "40/45 (89%) had primary orthostatic tremor with (n = 30) or without (n = 10) an associated postural arm tremor. "

Therapies and Procedures

1.	Therapeutics 10/01/2000 - "Primary orthostatic tremor is a rare condition, with few reports describing therapies. " 05/01/1999 - "This study is the first trial of therapy in primary orthostatic tremor and suggests that levodopa can lead to good symptomatic relief in this potentially disabling condition." 10/01/2000 - "Pramipexole is a potential therapy for primary orthostatic tremor. "
2.	Denervation 09/15/2008 - "The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). " 09/15/2008 - "Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high-frequency OT. "
3.	Deep Brain Stimulation 07/01/2014 - "One patient with primary orthostatic tremor underwent thalamic deep brain stimulation surgery. " 01/01/2017 - "Primary orthostatic tremor: is deep brain stimulation better than spinal cord stimulation?"
4.	Spinal Cord Stimulation 01/01/2017 - "Primary orthostatic tremor: is deep brain stimulation better than spinal cord stimulation?"
5.	Ventriculoperitoneal Shunt 01/01/2022 - "The patient was admitted to a hospital several times and was diagnosed with primary orthostatic tremor and later hydrocephalus; thus, he received a ventriculoperitoneal shunt. "