Neural tube defects X-linked

Also Known As:

Anencephaly-Spina Bifida; Neural Tube Defects, X-Linked

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Nervous System Malformations: 35
  - Neural Tube Defects: 4299
    - Neural tube defects X-linked: 16
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Nervous System Malformations: 35
    - Neural Tube Defects: 4299
      - Neural tube defects X-linked: 16
- Inborn Genetic Diseases: 11939
  - X-Linked Genetic Diseases: 42
    - Neural tube defects X-linked: 16

Related Diseases

1.	Encephalocele (Encephalocele, Frontal)
2.	Neural Tube Defects (Exencephaly)
3.	Congenital Abnormalities (Deformity)
4.	Umbilical Hernia (Omphalocele)
5.	Cleft Palate (Palate, Cleft)

Experts

1.	National Birth Defects Prevention Study: 3 articles (11/2020 - 11/2009)
2.	Anderka, Marlene: 2 articles (11/2020 - 10/2017)
3.	Romitti, Paul A: 2 articles (11/2020 - 11/2009)
4.	Wang, Meng: 2 articles (12/2016 - 03/2014)
5.	Wang, Zhi-Ping: 2 articles (12/2016 - 03/2014)
6.	Zhao, Zhong-Tang: 2 articles (12/2016 - 03/2014)
7.	Canfield, Mark A: 1 article (11/2020)
8.	Desrosiers, Tania A: 1 article (11/2020)
9.	Fisher, Sarah C: 1 article (11/2020)
10.	Heinke, Dominique: 1 article (11/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neural tube defects X-linked:

1.	Folic Acid (Vitamin M)FDA LinkGeneric 12/01/2016 - "The specific effects of folic acid supplementation during different periods show the reduction in the risk of NTDs, anencephaly, spina bifida, encephalocele. " 03/01/2000 - "Women of childbearing age who are capable of becoming pregnant should ingest 0.4 mg of folic acid per day to reduce the incidence of neural tube defects (anencephaly, spina bifida, and encephalocele). " 07/20/1991 - "A randomised double-blind prevention trial with a factorial design was conducted at 33 centres in seven countries to determine whether supplementation with folic acid (one of the vitamins in the B group) or a mixture of seven other vitamins (A,D,B1,B2,B6,C and nicotinamide) around the time of conception can prevent neural tube defects (anencephaly, spina bifida, encephalocele). "
2.	Anticonvulsants (Antiepileptic Drugs)IBA 01/01/1994 - "At least two maternal conditions have been shown to be associated with an increased risk for the occurrence of anencephaly, spina bifida and encephalocele: insulin-dependent diabetes mellitus in the mother and maternal epilepsy for which anticonvulsant treatment is being used. " 11/01/2020 - "We used data on 3994 birth defects cases and 11 829 controls enrolled in the National Birth Defects Prevention Study to compare odds ratio (OR) estimates of the relationship between three established risk factors (antiepileptic drug use, smoking, and multifetal pregnancy) and four birth defects (anencephaly, spina bifida, omphalocele, and cleft palate) when restricted to livebirths as compared to among livebirths, stillbirths, and elective terminations. " 01/01/1994 - "Of 147 infants born at the Brigham and Women's Hospital with anencephaly, spina bifida and encephalocele among 123,489 live-born, still-born and elective terminations surveyed, 7.5% were infants of insulin-dependent diabetics and 0.7% had been exposed to anticonvulsants in utero. "
3.	VitaminsIBA 07/20/1991 - "A randomised double-blind prevention trial with a factorial design was conducted at 33 centres in seven countries to determine whether supplementation with folic acid (one of the vitamins in the B group) or a mixture of seven other vitamins (A,D,B1,B2,B6,C and nicotinamide) around the time of conception can prevent neural tube defects (anencephaly, spina bifida, encephalocele). "
4.	Niacinamide (Nicotinamide)FDA LinkGeneric 07/20/1991 - "A randomised double-blind prevention trial with a factorial design was conducted at 33 centres in seven countries to determine whether supplementation with folic acid (one of the vitamins in the B group) or a mixture of seven other vitamins (A,D,B1,B2,B6,C and nicotinamide) around the time of conception can prevent neural tube defects (anencephaly, spina bifida, encephalocele). "
5.	Caffeine (No Doz)FDA LinkGeneric 11/01/2009 - "Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS). "
6.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/15/1979 - "The amniotic fluid alpha-fetoprotein assay (AF-AFP) is the single most valuable method of detecting anencephaly--spina bifida (ASB) in utero. " 01/01/1986 - "Alpha-fetoprotein (AFP) quantitation in maternal blood has been used for prenatal diagnosis of anencephaly, spina bifida and some other congenital abnormalities. "
7.	Tobacco Smoke Pollution (Passive Smoking)IBA 03/01/2014 - "The pooled effect estimate of maternal passive smoking was 1.82 (95% CI 1.46-2.27) for total NTDs; the effect estimates were 1.72 (95% CI 1.44-2.06), 1.52 (95% CI 1.29-1.79), and 2.32 (95% CI 1.34-4.01) for NTDs subtypes of anencephaly, spina bifida and encephalocele, respectively. "
8.	TeratogensIBA 05/15/2005 - "Although most neural tube defects (anencephaly, spina bifida) occur as isolated malformations, a substantial proportion are attributable to chromosome anomalies, known teratogens, or component manifestations of multiple anomaly syndromes. "
9.	Insulin (Novolin)FDA Link 01/01/1994 - "Of 147 infants born at the Brigham and Women's Hospital with anencephaly, spina bifida and encephalocele among 123,489 live-born, still-born and elective terminations surveyed, 7.5% were infants of insulin-dependent diabetics and 0.7% had been exposed to anticonvulsants in utero. "
10.	Hormones (Hormone)IBA 05/18/1974 - "Letter: Anencephaly, spina bifida, dizygotic twinning, and hormones."