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Male sterility due to Y-chromosome deletions

Male infertility or reduced fertility that is caused by deletions in the Y chromosome.
Also Known As:
Partial deletion of Y; Partial deletion of Y chromosome short arm; Partial deletion of chromosome Y; Partial deletion of the long arm of the Y chromosome; Y chromosome deletions; Y chromosome microdeletions; Y-chromosome microdeletions
Networked: 83 relevant articles (0 outcomes, 12 trials/studies)

Disease Context: Research Results

Related Diseases

1. Azoospermia
2. Male Infertility (Male Sterility)
3. Oligospermia (Oligozoospermia)
4. Chromosome Aberrations (Chromosome Abnormalities)
5. Spontaneous Abortion (Miscarriage)

Experts

1. Liu, Ruizhi: 3 articles (07/2020 - 07/2019)
2. Mirfakhraie, Reza: 3 articles (09/2015 - 09/2010)
3. Hu, Xiaonan: 2 articles (07/2020 - 07/2019)
4. Li, Leilei: 2 articles (07/2020 - 01/2020)
5. Zhang, Hongguo: 2 articles (07/2020 - 01/2020)
6. Zhu, Haibo: 2 articles (07/2020 - 07/2019)
7. Wang, Ruixue: 2 articles (01/2020 - 07/2019)
8. Sakkas, Denny: 2 articles (11/2018 - 07/2005)
9. Seo, Ju Tae: 2 articles (07/2017 - 11/2007)
10. Ferlin, Alberto: 2 articles (11/2015 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Male sterility due to Y-chromosome deletions:
1. Hormones (Hormone)IBA
2. DNA (Deoxyribonucleic Acid)IBA
3. Androgen Receptors (Androgen Receptor)IBA
4. Follicle Stimulating Hormone (Follitropin)FDA Link
5. RNA (Ribonucleic Acid)IBA
6. Mitochondrial DNA (mtDNA)IBA
7. CateninsIBA
8. A-factor (Streptomyces)IBA
9. Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
10. Testosterone (Sustanon)FDA Link
11/01/2023 - "The AFU recommends: (1) a complete medical history including: family history, patient history affecting fertility, lifestyle habits (toxicity), treatments, symptoms, sexual dysfunctions; (2) a physical examination including: BMI, signs of hypogonadism, secondary sexual characteristics, scrotal examination (volume and consistency of testes, vas deferens, epididymal or testicular nodules, presence of varicocele); (3) two spermograms, if abnormal on the first; (4) a systematic scrotal ultrasound,± an endorectal ultrasound depending on the clinic; (5) a hormonal work-up (testosterone, FSH; if testosterone is low: LH assay to differentiate between central or peripheral hypogonadism); (6) karyotype if sperm concentration≤10 million/mL; (7) evaluation of Y chromosome microdeletions if concentration≤1 million/mL; (8) evaluation of the CFTR gene in cases of suspected bilateral or unilateral agenesis of the vas deferens and seminal vesicles. "
06/01/2012 - "Hormonal analysis (follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels), semen analysis, karyotype analysis, and PCR screening for Y chromosome microdeletions were performed. "
12/23/2015 - "For each patient, the testicular volume, endocrine profile [follicle stimulating hormone (FSH), luteinizing hormone (LH), free testosterone (FT), total testosterone (TT)], serum inhibin B level, karyotype analysis, and Y chromosome microdeletions were recorded, and all data were analyzed to detect any predictors. "

Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Vasovasostomy (Vasectomy Reversal)
4. Vasectomy (Vas Occlusion)
5. Therapeutics