Ehlers-Danlos syndrome type 3

A hypermobility type of Ehlers-Danlos Syndrome (EDS), characterized by hyperxtensibility of the joints, recurrent joint dislocations, and the onset of OSTEOARTHRITIS in the fourth decade of life. MITRAL VALVE PROLAPSE may also be present. Skin abnormalities are less severe than in other forms of the EDS. Mutations in the COL3A1 and the TNXB genes have been identified. OMIM: 130020

Also Known As:

Networked: 18 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Chronic Pain
2.	Ehlers-Danlos syndrome type 3
3.	Postural Orthostatic Tachycardia Syndrome
4.	Williams Syndrome (Williams-Beuren Syndrome)
5.	Radiculopathy (Radiculopathy, Cervical)

Experts

1.	Aboagye, Evans: 1 article (01/2022)
2.	Asafu Adjaye Frimpong, George: 1 article (01/2022)
3.	Chigbu, Naomi Cindy Chinenyenwa: 1 article (01/2022)
4.	Daboner, Victoria Temabore: 1 article (01/2022)
5.	Tannor, Elliot Koranteng: 1 article (01/2022)
6.	Gopen, Quinton: 1 article (11/2021)
7.	Miller, Jessa: 1 article (11/2021)
8.	Unterberger, Ansley: 1 article (11/2021)
9.	Yang, Isaac: 1 article (11/2021)
10.	Campos-Xavier, Belinda: 1 article (01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ehlers-Danlos syndrome type 3:

1.	CollagenIBA 11/01/2021 - "Ehlers-Danlos syndrome, hypermobility type (EDS-HT) is a genetic collagen synthesis disorder, often resulting in bony abnormalities. " 01/01/1990 - "The biochemical properties, ratio collagen type I/type III and the pattern of reducible collagen crosslinks were studied in skin biopsy samples from 10 patients with Ehlers Danlos syndrome type III (ED III) and 10 age- and sex-matched controls. " 01/01/2022 - "Considering the non-specific indications and the overlap of ATS with other disorders of the connective tissue such as Williams Beuren syndrome (elastin), Marfan syndrome (fibrillin-1) and Ehlers Danlos syndrome (Type III collagen), it is vital to keep a high diagnostic suspicion in the analysis of the condition. "
2.	Collagen Type III (Type III Collagen)IBA 09/01/1994 - "A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen."
3.	Collagen Type I (Type I Collagen)IBA 01/01/1990 - "The biochemical properties, ratio collagen type I/type III and the pattern of reducible collagen crosslinks were studied in skin biopsy samples from 10 patients with Ehlers Danlos syndrome type III (ED III) and 10 age- and sex-matched controls. "
4.	Tramadol (K315)FDA LinkGeneric 01/01/2004 - "Tramadol hydrochloride was administered (50 mg/day to 150 mg/day) to two siblings with Ehlers-Danlos syndrome - Hypermobility type refractory to previous pharmacological treatments, and changes in pain intensity and physical activity were assessed. " 01/01/2004 - "Treatment of pediatric chronic pain with tramadol hydrochloride: siblings with Ehlers-Danlos syndrome - Hypermobility type."
5.	SolutionsIBA 05/01/2004 - "Three injections of a solution of equal parts betamethasone (Celestone) and bupivacaine (Marcaine) were curative in a male patient with Ehlers-Danlos syndrome type III with PPPP. "
6.	Serine (L-Serine)FDA Link 09/01/1994 - "A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen."
7.	RelaxinIBA 01/01/2015 - "Serum relaxin levels in benign hypermobility syndrome."
8.	Lidocaine (Xylocaine)FDA LinkGeneric 07/01/1990 - "The analgesic effects of intradermal lidocaine infiltration and topical EMLA cream applications (eutectic mixture of local anaesthetics) were studied in 8 patients with Ehlers Danlos syndrome type III, a heritable disorder of connective tissue, and in 8 controls. "
9.	Glycine (Aminoacetic Acid)FDA LinkGeneric 09/01/1994 - "A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen."
10.	ElastinIBA 01/01/2022 - "Considering the non-specific indications and the overlap of ATS with other disorders of the connective tissue such as Williams Beuren syndrome (elastin), Marfan syndrome (fibrillin-1) and Ehlers Danlos syndrome (Type III collagen), it is vital to keep a high diagnostic suspicion in the analysis of the condition. "

Therapies and Procedures

1.	Injections 01/01/2017 - "Chronic pain in a patient with Ehlers-Danlos syndrome (hypermobility type): The role of myofascial trigger point injections." 05/01/2004 - "Three injections of a solution of equal parts betamethasone (Celestone) and bupivacaine (Marcaine) were curative in a male patient with Ehlers-Danlos syndrome type III with PPPP. "
2.	Cesarean Section (Caesarean Section) 10/01/2008 - "We report the use of regional anaesthesia for elective caesarean section in a primigravida with hypermobility type Ehlers-Danlos syndrome (type III) associated with postural orthostatic tachycardia syndrome. " 10/01/2009 - "There have been several reports of resistance to local anaesthetic agents in women with Ehlers-Danlos syndrome, hypermobility type, also known as Ehlers-Danlos syndrome Type III. General anaesthesia with rapid sequence induction was performed for caesarean section due to prolonged second stage of labour, but intubation proved to be difficult. "
3.	Physical Therapy Modalities (Physical Therapy Technique) 07/01/2018 - "A multimodal physical therapy approach utilizing the Maitland concept in the management of a patient with cervical and lumbar radiculitis and Ehlers-Danlos syndrome-hypermobility type: A case report."
4.	Orthotic Devices (Orthosis) 01/01/2017 - "Ehlers-Danlos Syndrome, Hypermobility Type: Impact of Somatosensory Orthoses on Postural Control (A Pilot Study)."
5.	Exercise Therapy (Therapy, Exercise) 01/01/2019 - "Implications for rehabilitation Exercise is a cornerstone of treatment for Ehlers-Danlos syndrome/Ehlers-Danlos syndrome - hypermobility type. "